A case study using the United Republic of Tanzania: costing nationwide HPV vaccine delivery using the WHO Cervical Cancer Prevention and Control Costing Tool
© Hutubessy et al; licensee BioMed Central Ltd. 2012
Received: 2 June 2012
Accepted: 13 November 2012
Published: 13 November 2012
The purpose, methods, data sources and assumptions behind the World Health Organization (WHO) Cervical Cancer Prevention and Control Costing (C4P) tool that was developed to assist low- and middle-income countries (LMICs) with planning and costing their nationwide human papillomavirus (HPV) vaccination program are presented. Tanzania is presented as a case study where the WHO C4P tool was used to cost and plan the roll-out of HPV vaccines nationwide as part of the national comprehensive cervical cancer prevention and control strategy.
The WHO C4P tool focuses on estimating the incremental costs to the health system of vaccinating adolescent girls through school-, health facility- and/or outreach-based strategies. No costs to the user (school girls, parents or caregivers) are included. Both financial (or costs to the Ministry of Health) and economic costs are estimated. The cost components for service delivery include training, vaccination (health personnel time and transport, stationery for tally sheets and vaccination cards, and so on), social mobilization/IEC (information, education and communication), supervision, and monitoring and evaluation (M&E). The costs of all the resources used for HPV vaccination are totaled and shown with and without the estimated cost of the vaccine. The total cost is also divided by the number of doses administered and number of fully immunized girls (FIGs) to estimate the cost per dose and cost per FIG.
Over five years (2011 to 2015), the cost of establishing an HPV vaccine program that delivers three doses of vaccine to girls at schools via phased national introduction (three regions in year 1, ten regions in year 2 and all 26 regions in years 3 to 5) in Tanzania is estimated to be US$9.2 million (excluding vaccine costs) and US$31.5 million (with vaccine) assuming a vaccine price of US$5 (GAVI 2011, formerly the Global Alliance for Vaccines and Immunizations). This is equivalent to a financial cost of US$5.77 per FIG, excluding the vaccine cost. The most important costs of service delivery are social mobilization/IEC and service delivery operational costs.
When countries expand their immunization schedules with new vaccines such as the HPV vaccine, they face initial costs to fund critical pre-introduction activities, as well as incremental system costs to deliver the vaccines on an ongoing basis. In anticipation, governments need to plan ahead for non-vaccine costs so they will be financed adequately. Existing human resources need to be re-allocated or new staff need to be recruited for the program to be implemented successfully in a sustainable and long-term manner.
Reaching a target group not routinely served by national immunization programs previously with three doses of vaccine requires new delivery strategies, more transport of vaccines and health workers and more intensive IEC activities leading to new delivery costs for the immunization program that are greater than the costs incurred when a new infant vaccine is added to the existing infant immunization schedule. The WHO C4P tool is intended to help LMICs to plan ahead and estimate the programmatic and operational costs of HPV vaccination.
KeywordsHuman papillomavirus (HPV) vaccines immunization programs costing planning United Republic of Tanzania low- and middle-income countries GAVI Alliance GAVI eligible countries
Cervical cancer caused by infection with carcinogenic types of human papillomavirus (HPV) is the second most common cancer in women worldwide according to age-standardized incidence rates (ASR). In 2008, there were more than a half million new cases and 274,000 deaths due to cervical cancer . More than 85% of these cases occurred in low- and middle-income countries (LMICs), with the highest incidence rates in Sub-Saharan Africa, South-Central Asia, Latin America and Melanesia . The United Republic of Tanzania has one of the highest cervical cancer burdens in the world and the highest in Eastern Africa, with an ASR of 50.9 cases per 100,000 women.
The World Health Organization (WHO) recommends routine vaccination of 9- to 13-year-old girls to protect against HPV infections with types 16 and 18, which contribute to the development of approximately 70% of cervical cancers  in countries where: (1) the prevention of cervical cancer and/or other HPV-related diseases is a public health priority; (2) vaccine introduction is programmatically feasible; (3) sustainable financing can be secured; and (4) the cost-effectiveness of vaccination strategies in the country or region has been duly considered . In most LMICs, the vaccine price offered to the public sector (ranging from US$15 to more than US$130 per dose) has been a barrier for vaccine uptake. The GAVI Alliance (formerly the Global Alliance for Vaccines and Immunization) is opening a finance window to purchase HPV vaccine at or about US$5 per dose in order to co-finance the vaccine with GAVI-eligible countries that apply and receive approval . While the vaccine price is a key driver on the cost side, national governments and donors will also need to consider additional resources to support implementation costs associated with delivery of vaccine to a new target population that has not been routinely vaccinated previously. To date, while vaccine delivery costs for small-scale demonstration projects in India, Peru, Uganda, Vietnam  and Tanzania  have been reported, data are lacking on large-scale, country-wide implementation costs. Hence, information on the affordability of different HPV vaccine delivery strategies in LMICs is limited.
As part of developing Tanzania's national comprehensive strategy for cervical cancer prevention and control, the Ministry of Health and Social Welfare (MOHSW) requested technical assistance from WHO to estimate the service delivery costs of introducing HPV vaccine into the country. This request was also in response to a MOHSW agreement to accept a three-year donation of HPV vaccine from the manufacturer. To address this request, WHO and their consultants developed the Cervical Cancer Prevention and Control Costing (C4P) tool in order to facilitate the decision-making process of program managers and policy makers by generating information on the projected costs of introducing cervical cancer interventions. The WHO C4P tool consists of a HPV Vaccine Module and a Cervical Cancer Screening and Treatment Module. As the latter component is still under development, this paper will focus only on the HPV vaccination component of the tool.
This paper aims to present the purpose, definitions, methods, data sources and assumptions behind the generic WHO C4P tool to assist LMICs with planning and costing their nationwide HPV vaccination program. Furthermore, Tanzania's experience and cost results will be presented in piloting the WHO C4P tool to scale up prevention interventions as part of their national comprehensive cervical cancer prevention and control plan.
Purpose of the generic tool
The generic costing tool is a country-specific costing and planning tool that facilitates data collection and enables the user to estimate and project the value of incremental (additional) resources required to add the country-wide delivery of HPV vaccine to an existing immunization program over a five-year period. In other words, it only estimates the value of new resources needed and does not include the cost of other goods and services (for example, transport) already being used for other vaccines (shared costs). For example, it does not estimate the cost of transporting HPV vaccine if this is part of the same transport used to deliver other vaccines such as rotavirus or traditional Expanded Program on Immunization (EPI) vaccines, such as diphtheria, tetanus and pertussis (DTP) from the central warehouse to the periphery in the country. Since the WHO C4P tool focuses on estimating the incremental costs of vaccinating adolescent girls from a public health care provider perspective, no costs to the user (school girls, parents and caregivers) are included.
Experience from the above-mentioned small-scale demonstration projects showed [5, 6] that the quantity of resources required to introduce HPV vaccine for national immunization programs (NIPs) will differ from those for new infant vaccines since it has a non-traditional target population--annual cohorts of girls 9- to 13-years old. Reaching this new and older target population with three doses of vaccine requires new delivery infrastructure, more transport for vaccines and health workers and more intensive IEC activities, leading to higher costs per vaccinated girl than costs per vaccinated infant for a new infant vaccine. That is, since the vaccine may be administered at venues such as schools or places in the community additional costs are incurred for outreach.
The HPV Vaccine Module of the WHO C4P tool enables the user to estimate the additional resource requirements based on identifying different vaccine delivery scenarios that could potentially be considered for the country. The tool allows the user to define different vaccine delivery strategies, for example, through schools, health facilities or campaigns, such as national immunization days. The tool provides estimates of several cost measures: (1) total costs of introducing the HPV vaccine in specific regions/provinces or at the national level; (2) delivery cost per dose; and (3) delivery cost per fully immunized girl (FIG) defined as the cost per dose multiplied by the total number of doses delivered over three vaccination rounds divided by the total number of girls who received all three doses as a function of coverage and dropout rates over all three vaccination rounds.
Cost categories and components of the tool
The WHO C4P tool allows the user to estimate the costs of activities that take place during the introduction of HPV vaccination into a national immunization program. These activities include the following: procurement of vaccines and injection supplies, micro-planning, training, social mobilization and IEC, purchase of cold chain equipment, service delivery of vaccines to target population, monitoring and evaluation, supervision and waste management. Typical users of the WHO C4P tool are national health planners without prior experience of HPV vaccine introduction.
The tool differentiates recurrent (operational) and capital costs as well as financial and economic costs. It also presents expenditures required for investments necessary during the first years of HPV vaccine introduction.
Recurrent costs are defined as the value of resources that last less than one year. These include program costs such as the value of personnel time, transport, maintenance, monitoring and evaluation, and supervision as well as costs of short-term training activities that last less than a year (for example, do not include material development and initial training).
Capital costs are the value of resources that last longer than one year, such as cold chain equipment and vehicles. The capital goods and services used in HPV vaccination include initial investments such as introduction costs (micro-planning, initial training and social mobilization/IEC material development) as well as additional cold chain equipment, vehicle requirements and incinerators.
Both financial and economic costs are calculated in the WHO C4P tool. The user can choose which one is most appropriate depending on the objective of the analysis. If the user wants to know the additional costs incurred or actual expenditures by the Ministry of Health, for example, they should focus on the financial cost calculation. Financial costs are the value of resources to the payer and include the value of actual resources purchased for the HPV vaccine introduction such as injection supplies, outreach allowances and per diem, resources used in training, and developing new communication materials useful for budgeting purposes.
Economic costs comprise the value of all outlays for vaccine introduction as well as those already paid for or owned by the Ministry of Health and other sources of financing, for example, the salaries of health personnel, vaccines paid for by partners and time of volunteers. This analysis is useful if the user is interested in evaluating the share of different sources of finance for the vaccine introduction. For example, they may want to know the share of total costs financed by the Ministry of Health, external partners, clients and the community. This analysis gives a more complete picture of resources that are tied up in the provision of the new vaccine and their opportunity costs and should be used if a cost-effectiveness or cost-benefit analysis is to be conducted.
Capital costs are calculated differently depending on whether financial or economic costs are being estimated. When calculating financial costs, straight-line depreciation is used in the calculation of capital costs. In other words, the cost of the item is annualized through dividing it by the useful life years of the good. For example, cold chain equipment could be expected to last for ten years and the total cost would be divided by ten. Straight-line depreciation assumes that capital goods are used up equally over the useful time period of the item. For economic costs, capital goods are discounted (at a 3% default discount rate) as well as annualized. This type of depreciation assumes that people have time preference and prefer to use goods and services now rather than in the future.
The main differences between financial and economic costing are: (1) the time spent by health personnel, school teachers and volunteers is valued in economic costing since there is an opportunity cost to this time - for example, the workers are unable to spend time on other activities when they are occupied with HPV vaccination - but are not included in financial costs since these are already paid for with government salaries; (2) the value of donated goods and services is included in economic costs but not in financial costs since there is an opportunity cost to their use; and (3) capital costs are calculated differently for financial and economist costs.
For planning purposes the user is able to identify and separate introduction costs (treated as a type of capital or fixed costs) from recurrent costs. Introduction costs are defined as resources required during the initial years of vaccine introduction (some may occur during the second or third year if the country has phased in vaccine introduction) while the recurrent costs are the running costs of the program such as transport of vaccines and health workers, allowances and per diems and monitoring and supervision.
Data sources and other assumptions of WHO C4P tool
Data Sources for Tanzanian Cost Analysis of HPV Vaccine Introduction.
Number of 10 year old girls
Number of health facilities, types and number of health staff
Number of primary schools
Ministry of Education
Health Staff Salaries
Unit Costs of hall rentals, facilitator fees, and other meetingexpenses, production of IEC materialsa
Survey of local costs
Unit costs of supplies
Transport allowances and per diems
Exchange and inflation rates
Ministry of Finance
Estimate from GAVI Alliance 2011
The data for the Tanzania analysis were taken from several information sources, as can be seen in Table 1, ranging from the MOHSW, the Ministry of Education (MOE) and the Ministry of Finance (MoF). The population estimates of ten-year-old girls were taken from UNDP.
The WHO C4P Vaccine Module: A case study for Tanzania
Basic assumptions for HPV vaccination program in Tanzania.
Description of assumption
Vaccine will be phased in over three years: 3 regions the first year, 10 regions thesecond year, and all 26 regions the 3rd, 4th and 5th years.
Girls enrolled in Primary 4 are a proxy of 10-year-old girls.
Four visits will be made to each school for orientation and to reach all of the girls.
No additional costs for the cold chain will be required.
Transport for bringing the vaccine to the health facilities will be integrated into existingtransport for EPI vaccines.
The coverage for girls age 10 is 85%, 77% and 65% in the 1st, 2nd and 3rd roundrespectively, vaccine wastage is 5%, a buffer stock of 25% is maintained.
The price per dose is assumed to be US$5 per dose based on the price offered to theGAVI Alliance by Merck.
The health worker spends half a day at each school and receives outreach per diem
The transport allowance from the health facility for a health worker to and from theschool costs on average 10,000 Tsh (US$6.30)
Vaccines will be donated during the first three years but MOHSW will pay for syringes,receiving, clearance, storage and transport of the vaccines to the health facilities.
Proposed HPV vaccine delivery strategy in Tanzania
The MOHSW of Tanzania is planning a phased school-based delivery strategy, beginning in three regions of the country, expanding to ten regions in the second year, and covering 26 regions during the third through fifth years. Nurses from health centers and dispensaries will travel to schools to provide vaccinations to girls in the Primary 4 level in the schools. The health workers will visit each school three to four times for planning and administration of three vaccine doses to the girls.
In preparation for the vaccination, the MOHSW will conduct trainings for health staff and develop and undertake sensitization meetings with communities, parents and the media to inform the general population about the benefits of the vaccination through IEC.
Planned activities in Tanzania
Training activities that are costed include a curriculum development workshop and the following trainings: training of trainers (ToT) workshops, district supervisors and vaccinators. Social mobilization and IEC activities included the following: (1) a sensitization, mobilization and communication guidelines and tools preparation workshop; (2) a district campaign preparation workshop; (3) materials development and production; (4) materials printing and airing; (5) sensitization meetings with the community; and (6) a media seminar for journalists. Radio spots are projected to air all three years, but national television advertisements will only take place in the third year when the vaccination is introduced in all of the regions, including Zanzibar.
The financial costs of service delivery are comprised of per diems and transport allowances for the health worker and per diems for the school teacher which have to be paid on top of their regular salaries. Procurement costs are incurred for receiving and storage of the vaccines at the port and transport of the vaccines to the zonal level, but do not include vaccine costs since these are donated commodities. The monitoring and evaluation costs are comprised of production costs for tally sheets and vaccination cards. The costs of supervision are for transport (fuel and maintenance of vehicles) and per diems incurred during the quarterly visits from the national level to the regions and districts. The waste management costs are for construction of incinerators, fuel for incinerators and/or transport of waste.
Economic costs of service delivery include the value of resources for financial costs as well as the value of the time of personnel time and donated vaccines and capital items.
Summary of expected outputs of introducing HPV vaccines in Tanzania, 2011-2015.
Fully immunized girls
Health workers trained
Health facilities mobilized
School vaccination sites added
The five-year cost of introducing a national phased-in HPV vaccine program during 2011 to 2015 in Tanzania is estimated to be US$9.2 million (excluding vaccine costs) and US$31.5 million (with vaccine) assuming a vaccine price of US$5 (GAVI 2011). This is equivalent to a financial cost of US$5.77 per fully immunized girl, excluding the vaccine cost.
Financial Costs of Introducing HPV Vaccine in Tanzania, 2011-2015 (2011 US$).
Number of regions
Social mobilization and IEC
M and E, Supervisiond
Financial and economic cost per dose and per fully immunized girl without and with vaccine costs (2011 US$).
Cost per dose
Cost per FIGa
Financial Costs of Introducing HPV Vaccine through school- and health facility-based strategies in Tanzania, 2011-2015 (2011 US$).
Health facility- based
Age of target population
Number of girls in target population
Introduction costs per eligible girl
Recurrent cost per dose
Recurrent costs for three doses per eligible girl
When countries expand their immunization schedule with a new vaccine such as HPV, they face initial costs to fund critical pre-introduction activities, as well as incremental system costs to deliver the vaccines on an ongoing basis. By using the WHO C4P, the Tanzania experience of introducing HPV vaccine through a phased school-based delivery strategy in all the 26 regions shows that the five-year recurrent total costs of introducing HPV vaccine (excluding vaccine cost) are around US$9.2 million, which is equivalent to US$5.77 per FIG to the government. These recurrent costs correspond to 0.7% of the government real expenditures on health, indicating that substantial ministry of health government resources, such as health personnel, are required to deliver the vaccine effectively. Actual resources required are dramatically higher when one considers the vaccine costs and shared costs included as part of the economic costs analysis, that is, approximately US$59 million over a five-year period.
This study shows that, other than procurement, the most important costs of service delivery are social mobilization/IEC and service delivery operational costs. Social mobilization and IEC activities are particularly important to ensure that broad coverage is achieved by informing the population about the benefits of HPV vaccination and supporting the service delivery strategy used. Governments need to plan ahead for these non-vaccine costs so that they will be financed adequately and human resources need to be re-allocated appropriately for the program to be successfully implemented in a sustainable and long-term manner.
To date, data availability on national HPV vaccination in LMICs is limited, which makes it difficult to validate the tool. However, the findings from the WHO C4P tool for Tanzania are consistent with existing information on recurrent costs from various small-scale demonstration projects from the Program for Appropriate Technology in Health (PATH) in India, Peru, Uganda and Vietnam  and the LSHTM project in Mwanza province in Tanzania . Furthermore, the WHO C4P tool for Tanzania findings are also consistent with scale-up cost estimates for national HPV vaccination studies using the WHO C4P tool for Uganda , Bhutan and Rwanda based on actual HPV vaccine introduction with actual expenditure data (personal communication with responsible EPI officers from Bhutan and Rwanda)a. These studies demonstrate that introduction costs for HPV vaccines are higher than those for existing vaccines such as meningitis A campaigns and combination DTP-HepB-Hib vaccine via routine infant EPI vaccination programs [8, 9] due to increased needs for IEC and social mobilization activities to sensitize the public about the benefits of HPV vaccines for adolescent girls.
From the nationwide-modeled experiences based on PATH demonstration projects, the average introduction costs per eligible girl are US$2.99 (range US$2.82 to US$3.07) and the recurrent costs to deliver three doses per eligible girl are US$4.17 (range US$3.51 to US$4.78) . As HPV vaccine introduction requires building up a new delivery infrastructure, the costs are significantly higher. From the three available projected nationwide-modeled HPV vaccination costing studies in Tanzania, Uganda and Bhutan, the average cost is about US$3.00 per 10-year old girl.
The resource requirements of IEC activities are a large component of total costs since these are considered to be important aspects for a successful introduction of HPV vaccination, a new vaccine that targets a non-traditional population of adolescent girls. The population will need to be assured of its safety and benefits and be provided with an explanation of why this vaccination is given only to girls and not boys. The costs of IEC activities are calculated for the following activities: (1) sensitization meetings with community leaders to inform them of the benefits of the intended vaccination activities; (2) production of leaflets and posters on the benefits of HPV vaccinations to be placed by service providers in clinics, schools and public locations in their catchment areas; (3) design and production of radio and/or television announcements on the HPV vaccine for the population; and (4) briefings with writers, journalists, editors, publishers and other media personnel to inform them about the benefits of the vaccine. As HPV vaccination is scaled up in these countries, more IEC activities will be required, given that airing of radio and TV announcements will be more effective once the vaccination is scaled up nationally.
The WHO C4P tool in its current version has several limitations. First, depending on the countries' characteristics, additional sizable costs might be expected from a societal perspective that are not included in the WHO C4P tool, such as private costs to schoolgirls, parents and caregivers and additional costs for the cold chain. Variation in the incremental cost to the health system of vaccinating adolescent girls by different countries is expected and can potentially be explained by country characteristics, such as size of the country, population density and proximity of health facilities to schools, current infrastructure of schools and health facilities and national income level as well as the intensity of the HPV vaccine introduction effort (Levin et al. in preparation). Secondly, monitoring and evaluation costs are restricted to production of tally sheets and vaccination cards. In reality, additional quality control or evaluative measures, such as cost of administrative personnel to evaluate coverage levels might be required.
Past experience from the African region for delivery of other adolescent health interventions such as school deworming programs with benzimidazoles  and school-targeted treatment for Schistosoma mansoni  suggest lower cost estimates per child compared to delivering an adolescent vaccine. More recently, costing data is becoming available on the delivery and scaling up of sexual and reproductive health interventions through adolescent-friendly health services. Pilot testing of a WHO costing tool in Uganda in 2006 found unit costs per adolescent child ranging from US$4.50 for sexually transmitted infection (STI) treatment in a public primary health facility to US$19 for HIV counseling and testing in a non-governmental organization (NGO)-run facility . Overall, however, accurate cost estimates of interventions delivered to young people are rare and more needs to be done to improve evaluations of the economic value of investments targeted at this age group .
In anticipation of these additional service delivery costs for HPV vaccines as an example for non-traditional vaccines, the GAVI Alliance is reviewing its current policy towards vaccine introduction grants and operational support for campaigns . GAVI's introduction grant is a one-time cash grant to fund some of the activities associated with adopting a new vaccine in a country's national immunization program . However, the vaccine introduction grant does not fund the total costs resulting from a new vaccine introduction. Governments and partners are expected to contribute additional funding in order to facilitate an effective introduction. Past experience has shown that governments have not always been able to quickly mobilize additional funding from their own budgets or development partners to fill these funding gaps. The WHO C4P tool could be used to assist countries in estimating the pre-introduction and incremental system costs to deliver the HPV vaccine.
Use of an early version of the Cervical Cancer Screening and Treatment Module of the WHO C4P tool demonstrates that the preliminary costs of scaling-up screening and treatment in Tanzania are estimated to be $12.1 million over five years. In the scenario examined, 1.2 million out of a target population of five million women are screened using visual inspection with acetic acid (VIA), while 17.4 thousand women out of 60 thousand VIA-positive women receive treatment. This estimate is based on screening at the health dispensary level and above and treatment at the health center level and above . Completion of the Cervical Cancer Screening and Treatment Module of the WHO C4P tool will further contribute to the decision-making process.
Finally, HPV vaccines are not the only new vaccines being considered for introduction in LMICs. There are also pneumococcal and rotavirus vaccines as well as several older vaccines that have not yet been broadly adopted in developing countries. Although intended for national HPV vaccination costing and planning purposes, the economic cost results of the WHO C4P tool can be used as an input for cost-effectiveness analysis and/or budget impact analysis in order to assist countries in setting their priorities between competing vaccines or other cervical cancer control options. In-country cost estimates of the programmatic costs of delivering an adolescent vaccine and scaling up of cervical cancer screening and treatment interventions as an input for cost-effectiveness analysis are rare. For instance, a health and economic impact study of HPV vaccination and cervical cancer screening in five Eastern African countries would have benefited from a country-specific data collection and projection costing tool such as WHO C4P to estimate these programmatic costs  among other tools.
The financial delivery costs of nationwide HPV vaccination are higher than those of infant vaccines and can be substantial in resource-poor settings since it requires building up new delivery channels. As a consequence, governments need to plan ahead for these non-vaccine costs so that they will have adequate finances in place for vaccine introduction.
As GAVI's vaccine portfolio is expanding and countries are expected to introduce new vaccines at an increasing rate, it is recommended to include (partial) funding for operational health system costs in order assist GAVI eligible countries in introducing HPV vaccines. Together with other decision-making tools, the WHO C4P tool could facilitate both low- and middle-income countries in demonstrating their ability to deliver HPV vaccines nationwide to the target population in an effective, sustainable and affordable manner.
aPersonal communication with Mr. Tandin Dorji, Chief Program Officer, Department of Public Health, Ministry of Health, Bhutan; and Mr. Maurice Gatera, Head of Vaccine Preventable Disease Division, Institute of HIV/AIDS Disease Prevention and Control, Rwanda Biomedical Center, Ministry of Health, Rwanda. Permission was obtained to quote their names.
age-standardized incidence rates
cervical cancer prevention and control costing
comprehensive multi-year plan
Expanded Program on Immunization
fully immunized girl
- GAVI Alliance:
formerly the Global Alliance for Vaccines and Immunisation
information: education and communication
low- and middle-income countries
London School of Hygiene and Tropical Medicine
monitoring and evaluation
Ministry of Health and Social Welfare
national immunization program
new and under-utilized vaccines implementation
Program for Appropriate Technology in Health
United Nations Development Program
visual inspection with acetic acid
World Health Organization.
We would like to thank Dafrossa Lyimo, Programme Manager Expanded Programme on Immunization, Ministry of Health and Social Welfare, Dar es Salaaam, Tanzania for her overall support and contribution to the country level data collection and country workshops; Carol Levin from PATH, Seattle, USA for reviewing the WHO C4P tool at an early stage of its development; Paul Bloem, Tracey Goodman, Miloud Kaddar and Pem Namgyal from the WHO Immunization, Vaccines and Biologicals (IVB) Department for their useful comments on earlier versions of the manuscript. In addition, we thank the participants of the WHO workshop on the WHO Cervical Cancer Control Costing and Planning (C4P) tool for Tanzania (28 to 29 July 2011 in Dar es Salaam, United Republic of Tanzania) and the WHO workshop for the Use and Development of a Cervical Cancer Control Planning (C4P) tool (6 to 7 December 2011 in Geneva, Switzerland) for their valuable comments and constructive suggestions to the further development of the WHO C4P tool. The GAVI Alliance and the Bill and Melinda Gates Foundation funded the development of the WHO C4P tool and Tanzania costing study. RH, SW and TJ are staff members of the World Health Organization. The views expressed are those of the authors and do not necessarily represent the views of the World Health Organization.
- Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010, 127: 2893-2917. 10.1002/ijc.25516.View ArticlePubMedGoogle Scholar
- Arbyn M, Castellsague X, de Sanjose S, Bruni L, Saraiya M, Bray F, Ferlay J: Worldwide burden of cervical cancer in 2008. Ann Oncol. 2011, 22: 2675-2686. 10.1093/annonc/mdr015.View ArticlePubMedGoogle Scholar
- Human papillomavirus vaccines. WHO position paper. Wkly Epidemiol Rec. 2009, 84: 118-131.
- GAVI Alliance: Humam papillomavirus vaccine support. [http://www.gavialliance.org/support/nvs/human-papillomavirus-vaccine-support/]
- Levin CE, Van Minh H, Odaga J, Sarit Rout S, Nguyen Thi Ngoc D, Menezes LMAAM, Lamontagne DS: Costs and financial affordability of delivery strategies to introduce HPV vaccine in India, Peru, Uganda and Vietnam. Bull World Health Organ.
- Quentin W, Terris-Prestholt F, Changalucha J, Soteli S, Edmunds WJ, Hutubessy R, Ross DA, Kapiga S, Watson-Jones D: Costs of human papillomavirus vaccination of school girls in Mwanza province, Tanzania. BMC Medicine.
- WHO New and Under-utilized Vaccines Implementation (NUVI) website. [http://www.who.int/nuvi/hpv/cervical_cancer_costing_tool/en/index.html]
- Colombini A, Badolo O, Gessner BD, Jaillard P, Seini E, Da SA: Costs and impact of meningitis epidemics for the public health system in Burkina Faso. Vaccine. 2011, 29: 5474-5480. 10.1016/j.vaccine.2011.05.058.View ArticlePubMedGoogle Scholar
- Griffiths UK, Korczak VS, Ayalew D, Yigzaw A: Incremental system costs of introducing combined DTwP-hepatitis B-Hib vaccine into national immunization services in Ethiopia. Vaccine. 2009, 27: 1426-1432. 10.1016/j.vaccine.2008.12.037.View ArticlePubMedGoogle Scholar
- Montresor A, Gabrielli AF, Diarra A, Engels D: Estimation of the cost of large-scale school deworming programmes with benzimidazoles. Trans R Soc Trop Med Hyg. 2010, 104: 129-132. 10.1016/j.trstmh.2009.10.007.View ArticlePubMedGoogle Scholar
- Guyatt HL, Chan MS: An investigation into the interaction between drug efficacy and drug price of praziquantel in determining the cost-effectiveness of school- targeted treatment for Schistosoma mansoni using a population dynamic model. Trop Med Int Health. 1998, 3: 425-435. 10.1046/j.1365-3156.1998.00248.x.View ArticlePubMedGoogle Scholar
- World Health Organization: Measuring the Costs of Health Services provided to Young People: guidance from a technical consultation meeting. 2007, Geneva, SwitzerlandGoogle Scholar
- Lule E, Rosen JE, Singh S, Knowles JC, Behrman JR: Adolescent Health Programs. Disease Control Priorities in Developing Countries (2nd Edition). Edited by: Jamison DT, Breman JG, Measham AR, Alleyne G, Claude M, Evans DB et al. 2006, New York: The World Bank; Oxford University Press, 1109-1125. 2Google Scholar
- GAVI secretariat: Vaccine introduction grants and operational support for campaigns policy. 2012, Version 1, Geneva SwitzerlandGoogle Scholar
- GAVI secretariat: Guidelines for applications new and underused vaccines support. 2012, Geneva, SwitzerlandGoogle Scholar
- Levin A, Morgan W, Wang SBN, Ally M, Tarimo K, John T, Hutubessy R: HPV costing tools assist planning in low resource country. International Papillomavirus Conference, Berlin, Germany, 17-22 September 2011. 2011Google Scholar
- Campos NG, Kim JJ, Castle PE, Ortendahl JD, O'Shea M, Diaz M, Goldie SJ: Health and economic impact of HPV 16/18 vaccination and cervical cancer screening in Eastern Africa. Int J Cancer. 2012, 130: 2672-2684. 10.1002/ijc.26269.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/10/136/prepub
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