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Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

  • Emanuel Severus1, 2Email author,
  • Florian Seemüller2,
  • Michael Berger2,
  • Sandra Dittmann2,
  • Michael Obermeier2,
  • Andrea Pfennig1,
  • Michael Riedel2, 3,
  • Sophia Frangou4,
  • Hans-Jürgen Möller2 and
  • Michael Bauer1
BMC Medicine201210:67

DOI: 10.1186/1741-7015-10-67

Received: 4 January 2012

Accepted: 2 July 2012

Published: 2 July 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
4 Jan 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
6 Mar 2012 Reviewed Reviewer Report - Jonathan W. Stewart
14 Mar 2012 Reviewed Reviewer Report - Bruno Falissard
1 May 2012 Author responded Author comments - Emanuel Severus
Resubmission - Version 3
1 May 2012 Submitted Manuscript version 3
18 May 2012 Reviewed Reviewer Report - Jonathan W. Stewart
19 May 2012 Reviewed Reviewer Report - Bruno Falissard
6 Jun 2012 Author responded Author comments - Emanuel Severus
Resubmission - Version 4
6 Jun 2012 Submitted Manuscript version 4
15 Jun 2012 Author responded Author comments - Emanuel Severus
Resubmission - Version 5
15 Jun 2012 Submitted Manuscript version 5
Publishing
2 Jul 2012 Editorially accepted
2 Jul 2012 Article published 10.1186/1741-7015-10-67

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technical University Dresden
(2)
Department of Psychiatry and Psychotherapy, LMU Munich
(3)
Vinzenz von Paul Hospital
(4)
Institute of Psychiatry, King's College London

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