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Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era

  • John F Brothers1, 2Email author,
  • Kahkeshan Hijazi1, 2,
  • Celine Mascaux3,
  • Randa A El-Zein4,
  • Margaret R Spitz4 and
  • Avrum Spira1, 2
Contributed equally
BMC Medicine201311:168

DOI: 10.1186/1741-7015-11-168

Received: 11 March 2013

Accepted: 20 June 2013

Published: 19 July 2013

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
11 Mar 2013 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
Resubmission - Version 3
Submitted Manuscript version 3
Resubmission - Version 4
Submitted Manuscript version 4
Resubmission - Version 5
Submitted Manuscript version 5
3 Apr 2013 Reviewed Reviewer Report - Wainer Zoli
3 Apr 2013 Reviewed Reviewer Report - Tommaso Dragani
Resubmission - Version 6
Submitted Manuscript version 6
Resubmission - Version 7
Submitted Manuscript version 7
11 Jun 2013 Author responded Author comments - Claire Barnard
Resubmission - Version 8
11 Jun 2013 Submitted Manuscript version 8
Resubmission - Version 9
Submitted Manuscript version 9
17 Jun 2013 Reviewed Reviewer Report - Wainer Zoli
Resubmission - Version 10
Submitted Manuscript version 10
20 Jun 2013 Editorially accepted
19 Jul 2013 Article published 10.1186/1741-7015-11-168

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Bioinformatics Program, Boston University
Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine
Department of Medical Oncology, Princess Margaret Cancer Centre, University of Health Network, University of Toronto
Dan L Duncan Cancer Center, Baylor College of Medicine