Millennium Development Goals 4 and 5: progress and challenges
© Bryce et al.; licensee BioMed Central Ltd. 2013
Received: 12 September 2013
Accepted: 16 September 2013
Published: 16 October 2013
The Millennium Development Goals have galvanized efforts to improve child survival (MDG-4) and maternal health (MDG-5). There has been important progress on both MDGs at global level, although it now appears that few countries will reach them by the target date of 2015. There are known and efficacious interventions to address most of the major causes of these deaths, but important gaps remain. The biggest challenge is to ensure that all women and children have access to life-saving interventions. Current levels of intervention coverage are too low, representing missed opportunities. Providing services at the community level is an important emerging priority, but preventing maternal and neonatal deaths also requires access to health facilities. Readers of the Medicine for Global Health collectiona in BMC Medicine are urged to make maternal and child health one of their key concerns, even if they work on other topics.
KeywordsChild survival Child mortality Maternal survival Maternal health Maternal mortality Neonatal mortality Nutrition Millennium Development Goals
The eight Millennium Development Goals (MDGs) arose out of the United Nations Millennium Declaration of 2000, and set targets for levels of achievement for the period from 1990 to 2015 . MDG-4, “Reduce child mortality”, has a target of reducing the under-five mortality rate by two-thirds. MDG-5, “Improve maternal health”, has a target of reducing the maternal mortality ratio by three-quarters. Despite important limitations , the MDGs have galvanized and focused global attention and monitoring. MDGs 4 and 5 are important for global health as a whole, because they represent the mortality endpoints for women and children across specific diseases, nutritional and environmental risk factors, and more distal determinants including inequalities in economic resources and education. Under-five mortality is also one of the major determinants of life expectancy across the globe. In this brief commentary, we review progress regarding MDG-4 and MDG-5 in the 75 low- and middle-income countries (LMIC) that account for over 95% of maternal and child deaths .
The changing epidemiology of women’s and children’s health
Progress on MDG-4 for child survival has been impressive at the global level, although it now appears clear that the global target will not be reached . The number of deaths among children under five worldwide has decreased from 12.4 million  in 1990 to 7.6 million in 2010 , a reduction of nearly 40% in spite of an increase in the number of births. Child deaths continue to be concentrated in LMICs, and increasingly in sub-Saharan Africa and South Asia . Pneumonia, diarrhea and malaria together accounted for over 30% of under-five deaths in 2010, with three-quarters of deaths due to major infections occurring in the first two years of life . Under-nutrition contributes to nearly half of all child deaths . As deaths in the 1- to 59-month age group decline, deaths in the first 28 days (neonatal deaths) represent a growing proportion of all under-five deaths. The major causes of neonatal deaths in 2010 were preterm birth complications, intrapartum complications and pneumonia/sepsis .
Progress on MDG-5 for maternal health has been slower than for MDG-4, with deaths declining from around 400,000 to around 275,000 [8, 9]. The major causes of maternal deaths in 2010 are estimated to have been hemorrhage (22.9%), hypertensive disorders (18.5%), abortion (14.6%), sepsis (8.6%), and other direct and indirect causes (35.5%) .
What interventions are available, and where are the gaps?
There has been important progress in identifying interventions to reduce mortality from the major causes of child deaths, but gaps remain. For pneumonia, the newly-implemented vaccine for pneumococcal disease holds potential for sizable impact, but fails to protect against prevalent serotypes in some LMICs . Antibiotic treatment of bacterial pneumonia is highly efficacious, but may be compromised by increasing resistance of bacteria to inexpensive antibiotics . There is no available treatment or vaccines for important viral causes of lower respiratory illness, such as Respiratory Syncytial Virus. For diarrhea, rotavirus is the most important cause of severe childhood diarrhea globally, but the vaccine that is currently implemented appears to provide only about 50% protection in low-income countries . Oral rehydration salts (ORS) solution and zinc are effective treatments, but coverage remains too low . For malaria, early results suggest that the currently available vaccine may offer only modest protection of young children in highly endemic areas [13, 14]. Long-lasting insecticide-treated nets that extend the period of protection from 6 to 12 months to three years or longer have been scaled up in the majority of countries where Plasmodium falciparum is a major cause of child deaths, but the duration of protection varies by product and remains under investigation [15, 16]. Moreover, resistance to anti-malarial drugs is emerging [13, 17]. One important advance is the development and scaling up of rapid diagnostic tests to allow better targeting of treatment for both malaria and pneumonia.
Preventing neonatal and maternal deaths is challenging, especially where access to health facilities is limited. Chlorhexidine, which is an antiseptic and disinfectant agent, applied to the umbilical cord at birth reduces deaths related to neonatal infection and is ready for implementation . However, preventing intrapartum complications, such as obstructed labor and hemorrhage, two leading causes of maternal deaths, managing babies that are born very early, and treating neonatal sepsis, all require good practices at the time of labor and delivery and preferably access to health facilities.
Achieving and sustaining high and equitable coverage
The reasons why few Governments in low-income countries have been able to achieve high, sustained and equitable coverage for interventions proven to reduce maternal and child deaths vary by setting and are not fully understood. Certainly resources - both foreign aid and domestic investments - are a limiting factor [20, 21], as are competing global priorities that do not always focus on the major causes of death. Rapid gains in coverage for insecticide-treated nets for malaria prevention and complex interventions to reduce maternal-to-child transmission of HIV demonstrate what can be done given adequate political will and external financing . Conflict and limited technical capacity at country level are also important impediments. However, the interplay of these factors at national and sub-national levels in the highest-burden countries needs further research, and there is unlikely to be a “one-size-fits-all” solution.
Future directions and conclusions
The MDGs have focused efforts on reduction of maternal and child mortality. In the post-2015 era, the health of women and children must remain a priority, and the MDG targets must be extended. Governments must be empowered to address the major causes of mortality in their context, but the lens should be expanded to include maternal morbidity, maternal and child nutrition, and child development. Programs must have the capacity to identify the women and children who are not being reached, and to develop local solutions for ensuring that even those disenfranchised by poverty, ethnicity, gender or conflict have continuous access to services delivered at levels of quality that ensure their effectiveness . Researchers and practitioners, including all those who follow the Medicine for Global Health collection, must ensure that the health of women and children in LMICs is properly addressed, whatever the specific focus of their research. The biggest challenge ahead is to combat complacency, and to recognize that the gains made to date only increase our responsibility to ensure that no woman, mother, baby or child dies unnecessarily.
aPlease see the Medicine for Global Health article collection: http://www.biomedcentral.com/bmcmed/series/MGH.
Low- and middle-income country
Millennium Development Goal
Oral rehydration salts.
- We Can End Poverty: Millennium Development Goals and Beyond. 2015, http://www.un.org/millenniumgoals/.Google Scholar
- Waage J, Banerji R, Campbell O, Chirwa E, Collender G, Dieltiens V, Dorward A, Godfrey-Faussett P, Hanvoravongchai P, Kingdon G, Little A, Mills A, Mulholland K, Mwinga A, North A, Patcharanarumol W, Poulton C, Tangcharoensathien V, Unterhalteret E: The Millennium Development Goals: a cross-sectoral analysis and principles for goal setting after 2015. Lancet. 2010, 376: 991-1023. 10.1016/S0140-6736(10)61196-8.View ArticlePubMedGoogle Scholar
- Requejo J, Bryce J, Victora C, Deixel A, on behalf of Countdown to 2015 for Maternal, Newborn and Child Survival: Accountability for Maternal, Newborn & Child Survival: The 2013 Update. 2013, WHO and UNICEF: Geneva and New YorkGoogle Scholar
- Independent Expert Review Group for the Commission on Information and Accountability for Women’s and Children’s Health. Every Woman Every Child: Strengthening Equity and Dignity through Health. 2013, http://apps.who.int/iris/bitstream/10665/85757/1/9789241505949_eng.pdf.
- Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, Mathers C, Black RE, Child Health Epidemiology Reference Group of WHO and UNICEF: Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012, 379: 2151-2161. 10.1016/S0140-6736(12)60560-1.View ArticlePubMedGoogle Scholar
- Walker CL, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O’Brien KL, Campbell H, Black RE: Global burden of childhood pneumonia and diarrhea. Lancet. 2013, 381: 1405-1416. 10.1016/S0140-6736(13)60222-6.View ArticlePubMedGoogle Scholar
- Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, Ezzati M, Grantham-McGregor S, Katz J, Martorell R, Uauy R, the Maternal and Child Nutrition Study Group: Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013, 382: 427-451. 10.1016/S0140-6736(13)60937-X.View ArticlePubMedGoogle Scholar
- Lozano R, Wang H, Foreman KJ, Rajaratnam JK, Naghavi M, Marcus JR, Dwyer-Lindgren L, Lofgren KT, Phillips D, Atkinson C, Lopez AD, Murray CJ: Progress towards Millennium Development Goals 4 and 5 on maternal and child mortality: an updated systematic analysis. Lancet. 2011, 378: 1139-1165. 10.1016/S0140-6736(11)61337-8.View ArticlePubMedGoogle Scholar
- UNFPA, UNICEF, WHO, World Bank: Trends in Maternal Mortality 1990-2010. 2012, http://www.unfpa.org/public/home/publications/pid/10728.Google Scholar
- Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, AlMazroa MA, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Abdulhak AB, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, et al: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012, 380: 2095-2128. 10.1016/S0140-6736(12)61728-0.View ArticlePubMedGoogle Scholar
- Mehr S, Wood N: Streptococcus pneumoniae - a review of carriage, infection, serotype replacement and vaccination. Paediatr Respir Rev. 2012, 13: 258-264. 10.1016/j.prrv.2011.12.001.View ArticlePubMedGoogle Scholar
- Thaver D, Ali SA, Zaidi AK: Antimicrobial resistance among neonatal pathogens in developing countries. Pediatr Infect Dis J. 2009, 28 (1 Suppl): S19-21.View ArticlePubMedGoogle Scholar
- White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM: Malaria. Lancet. 2013, [Epub ahead of print]Google Scholar
- RTS S, Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BG, Kabwende AL, Adegnika AA, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Machevo S, Acacio S, Bulo H, Sigauque B, Macete E, Alonso P, Abdulla S, Salim N, Minja R, Mpina M, Ahmed S, Ali AM, Mtoro AT, Hamad AS, Mutani P, Tanner M, Clinical Trials Partnership, et al: A phase 3 trial of RTS, S/AS01 malaria vaccine in African infants. N Engl J Med. 2012, 367: 2284-2295.View ArticleGoogle Scholar
- Kilian A, Byamukama W, Pigeon O, Gimnig J, Atieli F, Koekemoer L, Protopopoff N: Evidence for a useful life of more than three years for a polyester-based long-lasting insecticidal mosquito net in Western Uganda. Malar J. 2011, 10: 299-10.1186/1475-2875-10-299.View ArticlePubMedPubMed CentralGoogle Scholar
- Pulkki-Brännström AM, Wolff C, Brännström N, Skordis-Worrall J: Cost and cost effectiveness of long-lasting insecticide-treated bed nets - a model-based analysis. Cost Eff Resour Alloc. 2012, 10: 5-10.1186/1478-7547-10-5.View ArticlePubMedPubMed CentralGoogle Scholar
- Talisuna AO, Karema C, Ogutu B, Juma E, Logedi J, Nyandigisi A, Mulenga M, Mbacham WF, Roper C, Guerin PJ, D’Alessandro U, Snow RW: Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems. Lancet Infect Dis. 2012, 12: 888-896. 10.1016/S1473-3099(12)70241-4.View ArticlePubMedPubMed CentralGoogle Scholar
- Imdad A, Bautista RM, Senen KA, Uy ME, Mantaring JB, Bhutta ZA: Umbilical cord antiseptics for preventing sepsis and death among newborns. Cochrane Database Syst Rev. 2013, 5: CD008635.PubMedGoogle Scholar
- Bryce J, Arnold F, Blanc A, Hancioglu A, Newby H, Requejo J, Wardlaw T, CHERG Working Group on Improving Coverage Measurement: Measuring coverage in MNCH: new findings, new strategies, and recommendations for action. PLoS Med. 2013, 10: e1001423-10.1371/journal.pmed.1001423.View ArticlePubMedPubMed CentralGoogle Scholar
- Hsu J, Pitt C, Greco G, Berman P, Mills A: Countdown to 2015: changes in official development assistance to maternal, newborn, and child health in 2009–10, and assessment of progress since 2003. Lancet. 2012, 380: 1157-1168. 10.1016/S0140-6736(12)61415-9.View ArticlePubMedGoogle Scholar
- WHO: Global Health Expenditure Database. Child health. http://apps.who.int/nha/database/PreDataExplorer.aspx?d=2 (accessed 8 September, 2013)
- Walker N, Yenokyan G, Friberg IK, Bryce J: Patterns in coverage of maternal, newborn, and child health interventions: projections of neonatal and under-5 mortality to 2035. Lancet. 2013, 382: 1029-1038. 10.1016/S0140-6736(13)61748-1.View ArticlePubMedGoogle Scholar
- Bryce J, Victora CG, Black RE: The unfinished agenda in child survival. Lancet. 2013, 382: 1049-1059. 10.1016/S0140-6736(13)61753-5.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/11/225/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.