Constructlevel predictive validity of educational attainment and intellectual aptitude tests in medical student selection: metaregression of six UK longitudinal studies
 IC McManus^{1, 2}Email author,
 Chris Dewberry^{3},
 Sandra Nicholson^{4},
 Jonathan S Dowell^{5},
 Katherine Woolf^{1} and
 Henry WW Potts^{1}
DOI: 10.1186/1741701511243
© McManus et al.; licensee BioMed Central Ltd. 2013
Received: 26 June 2013
Accepted: 10 September 2013
Published: 14 November 2013
Abstract
Background
Measures used for medical student selection should predict future performance during training. A problem for any selection study is that predictoroutcome correlations are known only in those who have been selected, whereas selectors need to know how measures would predict in the entire pool of applicants. That problem of interpretation can be solved by calculating constructlevel predictive validity, an estimate of true predictoroutcome correlation across the range of applicant abilities.
Methods
Constructlevel predictive validities were calculated in six cohort studies of medical student selection and training (student entry, 1972 to 2009) for a range of predictors, including Alevels, General Certificates of Secondary Education (GCSEs)/Olevels, and aptitude tests (AH5 and UK Clinical Aptitude Test (UKCAT)). Outcomes included undergraduate basic medical science and finals assessments, as well as postgraduate measures of Membership of the Royal Colleges of Physicians of the United Kingdom (MRCP(UK)) performance and entry in the Specialist Register. Constructlevel predictive validity was calculated with the method of Hunter, Schmidt and Le (2006), adapted to correct for rightcensorship of examination results due to grade inflation.
Results
Metaregression analyzed 57 separate predictoroutcome correlations (POCs) and constructlevel predictive validities (CLPVs). Mean CLPVs are substantially higher (.450) than mean POCs (.171). Mean CLPVs for firstyear examinations, were high for Alevels (.809; CI: .501 to .935), and lower for GCSEs/Olevels (.332; CI: .024 to .583) and UKCAT (mean = .245; CI: .207 to .276). Alevels had higher CLPVs for all undergraduate and postgraduate assessments than did GCSEs/Olevels and intellectual aptitude tests. CLPVs of educational attainment measures decline somewhat during training, but continue to predict postgraduate performance. Intellectual aptitude tests have lower CLPVs than Alevels or GCSEs/Olevels.
Conclusions
Educational attainment has strong CLPVs for undergraduate and postgraduate performance, accounting for perhaps 65% of true variance in first year performance. Such CLPVs justify the use of educational attainment measure in selection, but also raise a key theoretical question concerning the remaining 35% of variance (and measurement error, range restriction and rightcensorship have been taken into account). Just as in astrophysics, ‘dark matter’ and ‘dark energy’ are posited to balance various theoretical equations, so medical student selection must also have its ‘dark variance’, whose nature is not yet properly characterized, but explains a third of the variation in performance during training. Some variance probably relates to factors which are unpredictable at selection, such as illness or other life events, but some is probably also associated with factors such as personality, motivation or study skills.
Keywords
Medical student selection Undergraduate performance Postgraduate performance Educational attainment Aptitude tests Criterionrelated construct validity Range restriction Right censorship Grade inflation Markov Chain Monte Carlo algorithmBackground
Selection of medical students in the UK and elsewhere depends heavily on prior measures of educational attainment, which in the UK mainly consists of GCE Alevels, ASlevels and General Certificates of Secondary Education (GCSEs), and Scottish Qualifications Authority (SQA) Highers and Advanced Highers. Such measures are currently problematic, in part because of continuing grade inflation, resulting in more and more students getting maximum grades, and partly because of concerns that educational attainment may reflect differences in secondary school quality, with the diversity of applicants and entrants thereby being reduced. As a result, in the past decade or so many medical schools in the UK, Australia, New Zealand and elsewhere have used additional selection measures such as tests of intellectual aptitude, examples being the UK Clinical Aptitude Test (UKCAT), Biomedical Admissions Test (BMAT), Undergraduate Medicine and Health Sciences Admission Test (UMAT) and Graduate Medical School Admissions Test (GAMSAT) [1].
The use of both educational attainment and intellectual ability for selection has been questioned because of doubts about how well they predict undergraduate performance at medical school (predictive validity) [1, 2]. A more general concern is that postgraduate performance, when doctors are in practice, should be predicted. Few studies have related postgraduate outcomes to educational attainment at secondary school, although the few that do suggest there are significant correlations [3, 4], resulting in what we have called the Academic Backbone, achievement at each academic stage, before, during and after medical school, predicting subsequent performance in assessments [4]. In the present paper, we assess the predictive validity and the constructlevel predictive validity of measures of educational attainment and intellectual ability, for undergraduate and postgraduate measures of achievement, in six prospective studies in the UK of medical school selection. In particular, we assess the theoretically crucial issue of the strength of the constructlevel predictive validity of educational attainment and intellectual ability in medical student selection.
Constructlevel predictive validity is a complex concept with a complex history [5–7], although in principle it is straightforward, at least in the statistically defined way in which we wish to use it, which follows the usage of Hunter et al.[8]. The constructlevel predictive validity of a selection measure in the context of medical school performance refers to the association between the construct assessed by the selection measure, the predictor and the medical knowledge, skills and attitudes measured by later undergraduate and postgraduate examinations, the outcomes. No measure is perfect, and constructlevel predictive validity takes that into account. Rather than simply specifying the correlation between scores on a measure of medical knowledge and scores on a measure used during selection to predict the capacity to acquire that knowledge, constructlevel predictive validity estimates the correlation between the underlying trait, knowledge or skill measured by the selection test, and the underlying medical knowledge measured in the examinations. If it were the case that, say, educational attainment were a perfect predictor of subsequently acquiring medical knowledge, then constructlevel predictive validity, the “true predictoroutcome correlation”, would be exactly one. In practice, no predictor could assess such an outcome perfectly, in part because predictors and outcomes are measured unreliably, and hence any actual correlation would fall short of unity. The calculation of constructlevel predictive validity takes unreliability and other practical problems of measuring the predictoroutcome into account, and hence estimates true predictoroutcome correlation, the correlation which would be found between the underlying construct measured by the outcome and the underlying construct measured by the predictor in an ideal world with ideal measures.
A deep problem for assessing selection is that while selection takes place in the entire pool of candidates or applicants, validation of the predictor measures can only take place in those who have entered medical school. However, the students admitted necessarily have higher and less variable scores on the predictor than those who are rejected, because those predictor scores are used as an integral part of the selection process. Predictor scores in those selected also have a smaller range (standard deviation) than in applicants overall. Restriction of range inevitably reduces the actual or empirical correlation which can be found between predictors and outcomes, meaning that actual predictoroutcome correlations in entrants to medical school are necessarily much smaller than the “true predictoroutcome correlations”, the constructlevel predictive validity coefficients. The principles underlying the estimation of constructlevel predictive validity, particularly in the presence of restriction of range, unreliability and rightcensorship are discussed in the section below.
Restriction of range, unreliability, rightcensorship and constructlevel predictive validity
To be effective in selection, a measure has to be a valid predictor of the outcome measure, which is shown on the vertical axis, and is usually job or course performance. The dotted, blue diagonal line in Figure 1 shows the relationship of the outcome measure to the selection measure. The relationship is not, of course, perfect and, hence, the data are scattered in an ellipse around the line, with the ratio of the short axis to the long axis being proportional to the correlation. The more tightly the points are clustered around the line, then the higher the correlation. Correlations depend in part on the range or variance in the x and y measures (and in the extreme case where all of the x values are the same, there is necessarily a correlation of zero). The effect of the range can be seen in Figure 1, where the green ellipse for the entrants has a lower correlation than that in the candidates, who in turn have a lower correlation than does the orange ellipse for the wider population.
The fundamental statistical problem in assessing selection measures is that the correlation between the outcome measure and the selection measure is only known in those who have been accepted (that is, the green ellipse in Figure 1, the relationship there being shown by the solid blue line). However, the correlation in entrants is inevitably lower than the correlation in applicants because of restriction of range. The validity of a selection measure is not indicated by how well it differentiates between those who have already been selected (which is rarely a useful thing to know in practical terms), but by predicting how badly candidates with lower selection scores would have performed on the course were they to have been admitted. The correlation between the selection and outcome measures is known as the constructlevel predictive validity of the selection measure. By making some reasonable assumptions about underlying processes, the constructlevel predictive validity can be inferred from the correlation of selection and outcome measures in entrants, and then applied to all applicants rather than just those who are selected.
So far, an assumption has been made that selection and outcome measures are measured without error, that is, if a person had their scores measured on two separate occasions then those two scores would be identical. In practice, that never happens, and any behavioural measure shows measurement error. In Figure 1 the gray circle shows the true selection and outcome scores for a candidate, c, with the arrows indicating the likely errors in that measurement. If c is a weak candidate then their true score may have happened to be below that required for selection, but they got lucky; and likewise strong candidates can occasionally have error against them and they are not selected. Without measurement error, the relationship between the selection measure and the outcome measure would be the blue solid and dotted lines of Figure 1. Measurement error, though, results in the fitted line (the regression line), having a lower slope than the true line (and that is indicated by the solid green line in the group of entrants, in whom that relationship is measured). As an additional complication, estimates of the reliability of the selection measure will be lower if calculated only in the group of entrants, because of restriction of range.
The importance of constructlevel predictive validity
A key error in selection is to assess the validity of selection measures by looking at correlations in those who have entered medical school, such correlations often seeming to be disappointingly small, to the extent that even in prestigious journals a naïve interpretation can be made that selection measures, such as Alevel grades, are actually of little value [9]. Within medicine, four decades ago, in 1973, Sir George Smart made exactly the same error when he said at a UK’s General Medical Council (GMC) conference that,
“As predictors of future performance [,] examinations were not highly successful, as was shown by the low correlation of A level GCE grades with subsequent performance in medical school” [10] (p. 5).
However thirty years before that, in 1943, Burt was already talking of the “timehonoured fallacy”, of,
“judging the efficiency of [an] examination as a mean of selection by stating its efficiency as a means of predicting the order of merit within the selected group” [11] (p. 2).
The fallacy, rightly socalled and very prevalent, is that correlations within a selected group are useful indicators of the true predictive validity of a selection measure. In fact, they are measuring something of little real interest, which is the ability of a test to predict how students who enter medical school will actually perform in medical school. What selectors really need to know is how well all applicants, not only those selected but also those rejected, would have performed in medical school were they to have been accepted. Constructlevel predictive validity provides an estimate of precisely that. The fallacy is easily seen in a simple thought experiment. Imagine that all accepted students gain AAA at Alevel. Although the correlation with medical school performance would necessarily be zero, that would not mean that an applicant admitted with grades of EEE would also perform equally well.
If constructlevel predictive validity, the “true predictoroutcome correlation”, is known, then it has great theoretical importance. Were constructlevel predictive validity to be one, then in principle the predictor and the outcome measure equivalent, parallel processes, and the predictor is indeed valid. It may not be perfect in practice, but that is something that can be improved upon by test refinement to improve reliability, and so on. If, however, the constructlevel predictive validity is less than one then there is a strong theoretical implication that even though the predictor may be measuring something useful, something else must also be important in predicting the remaining variance in the outcome. And whatever that something else is, it must necessarily be conceptually distinct from and statistically independent of the predictor measure. In the case of medical student selection it may be personality, motivation, communicative ability, life events or whatever, which are not measured by selection tests. The important thing is that a constructlevel predictive validity of less than one for a predictor, such as educational attainment, sets limits on the capacity of that particular predictor to explain outcomes, and other predictors must therefore also be sought. A very practical implication of such a theoretical analysis of constructlevel predictive validity is that it emphasizes where efforts in selection can and should be made. Were prior educational attainment to have a constructlevel predictive validity of one then it, and it alone, should be the focus of selection, assuming that the major concern of selectors is that future students and doctors should be able to acquire adequate clinical knowledge and hence pass examinations (and students who fail examinations and leave medical school certainly do not go on to become doctors). Were, however, educational attainment’s constructlevel predictive validity to be less than one then selection should search for and take into account those other characteristics which in part contribute to whether or not students and doctors are better able to pass examinations.
The statistical challenge of estimating constructlevel predictive validity is to work backwards from the “actual predictoroutcome correlation” to the “true predictoroutcome correlation”. The principles of that process have been known for many decades [5, 11–15], and the problem is now, in general, statistically tractable [8, 16]. As well as the actual predictoroutcome correlation, such methods of calculation require information on the distribution of predictor scores in both entrants and medical school applicants, and reliability estimates are also needed, both for the predictor variable in the pool of applicants, and the outcome variable in the entrants. Given those, constructlevel predictive validity can be estimated, using the method of Hunter et al. [8]. In the present case there are also two other technical issues. First, as we show in the statistical appendix (Additional file 1), the Hunter et al. method is effective if all of the measures are normally distributed, but it can produce erroneous results if the predictor measure is heavily ‘rightcensored’, as is the case for Alevels and Highers, where many candidates have maximum scores of 3 As at Alevel or 5 As at Highers. Second, the Hunter et al. method does not provide estimates of the standard error or the confidence intervals of estimates of constructlevel predictive validity. The solution for both problems, which we have implemented, is to modify the Hunter et al. method for rightcensored distributions (and also for binary or ordinal outcome measures, as occurs in some cases), using the Markov chain Monte Carlo (MCMC) algorithm (see later). It is then possible to estimate constructlevel predictive validities with standard errors of the estimates. The details of the method are shown in the statistical appendix (Additional file 1).
Attainment vs aptitude
Selection measures used in medicine can be broadly divided into measures of attainment or achievement and measures of aptitude or ability [1]. Attainment tests, such as GCSEs and Alevels in the UK, typically assess knowledge and skills acquired during formal education, high achievement probably requiring not only intellectual ability but also motivation, appropriate study skills, and personality traits, such as conscientiousness and openness to experience. MCAT, used for selecting medical students in the United States [17], is clearly a measure of substantive understanding of basic sciences and is also an attainment test. In contrast, aptitude or ability tests, such as UKCAT and BMAT in the UK, emphasize, “intellectual capabilities for thinking and reasoning, particularly logical and analytical reasoning abilities” [18], and are regarded as measures of potential, independent of educational opportunity, and in many ways are conceptually similar to general mental ability or intelligence.
Implicit in the use of measures of academic attainment and of aptitude is an assumption that the measures assess skills or abilities which underpin performance in the undergraduate medical course and in postgraduate training and professional achievement. The major difference between selection based on aptitude and on attainment is that selection based on aptitude tests assumes that generic or specific thinking and reasoning skills are important predictors of medical school performance, whereas for attainment tests it is assumed that the substantive content of subjects, such as of biology or chemistry, is of direct help in subsequent medical training, and/or that attaining such basic scientific knowledge is an indirect indicator of motivation, intellectual ability or personality [2].
The present study
In the present study our primary aim is to assess the predictive and constructlevel validity of measures of secondary school attainment in the UK in predicting performance not only in undergraduate medical school examinations, but also in postgraduate training, where we will consider the Membership of the Royal Colleges of Physicians of the United Kingdom (MRCP(UK)), a major postgraduate medical examination taken by many UK medical graduates, as well as entry into the General Medical Council’s (GMC’s) Specialist Register. In addition, we also consider data on the predictive validity of aptitude tests, considering both the AH5 [19], an intelligence test specifically designed for university students, and the UKCAT [20], a test currently used in a majority of UK medical schools, data on the predictive validity of which have been presented in the UKCAT12 study of 12 UK medical schools [21].
Smallscale studies of selection have little statistical power for estimating constructlevel predictive validity and, therefore, in the present study we will estimate constructlevel predictive validity in six largescale cohort studies which have taken place in the UK over the past three and a half decades using a range of predictor and outcome measures. We have used metaregression [22] to assess how constructlevel predictive validities differ in relation to the outcome measures assessed (Basic Medical Sciences, Finals, MRCP(UK) and Specialist Register), to type of predictor measure (Alevel, ASlevel, GCSE, Higher, Advanced Higher, and intellectual aptitude tests (UKCAT and AH5)), and the year in which students entered medical school (1972 to 2009).
Overview of the datasets
The data for the present study come from six cohort studies analyzed in detail elsewhere, so only a summary is provided here. In order of year of entry of the students, the Westminster Study [3] is the oldest (entry 1972 to 1980), followed by the 1980 [23], 1985 [24] and 1990 [25] Cohort Studies (entry in 1981, 1986 and 1991), the University College London Medical School (UCLMS) Cohorts (entry 2001 to 2004) [26] and the UKCAT12 Study [21] (entry 2007 to 2009). Four of the studies, the 1980, 1985 and 1990 Cohort Studies and UKCAT12, are proper selection studies in that data are available not only for entrants to medical school but also for applicants. The remaining two studies, the Westminster Cohort and the UCLMS Cohorts have data only on entrants but the four selection studies proper allow estimates of the distributions of applicant measures in those two studies. The Westminster Cohort has a fulllength timed intellectual aptitude test (AH5), the 1990 Cohort has an abbreviated AH5, and UKCAT12 administered the UKCAT. Followup through the years of medical school is most detailed in the UCLMS Cohorts, and the UKCAT12 data analyzed here only include first year performance. UKCAT12 is, though, the largest study followed by the 1990 Cohort, all cohorts, except for UCLMS, have data on which doctors are on the Specialist Register, and the 1990 and UCLMS Cohorts have MRCP(UK) results.
Method
Six separate cohort studies were analyzed. Summaries of the studies are provided below, and more details are available elsewhere [4, 21]. In reverse order of medical school entry, the studies were:
The UKCAT12 study
Twelve UK medical schools (four in Scotland) that used UKCAT as a part of their selection took part in this study. Overall 1,666, 1,768 and 1,442 students entered the 12 medical schools in 2007, 2008 and 2009. Undergraduate performance was available as an overall score for the end of the first year of the course, and within each year of entry and medical school was expressed as a zscore (mean = 0, SD = 1) to allow comparability across the medical schools and cohorts. UKCAT scores were analyzed as the total score (range 1,200 to 3,600). Educational achievement was expressed as the total score on three best Alevels (scored A = 10, B = 8, C = 6, D = 4 and E = 2), four best ASlevels (scored as Alevels), nine best GCSEs (scored as A* = 6, A = 5, B = 4, C = 3, D = 2 and E = 1), five best SQA Highers (scored as A = 10, B = 8, C = 6 and D = 4), five best SQA “Highers plus” (scored as A1 = 10, A2 = 9, B3 = 8, B4 = 7, C5 = 6, C6 = 5, D7 = 4 and D8 = 3), and single best SQA Advanced Highers (scored as Highers Plus). Previous analyses [27] had also shown that the various measures of previous examination attainment could be combined into a single measure. For GCE examinations, the scores for the three best Alevels, four best ASlevels, nine best GCSEs, as well as grades in Alevel Biology, Chemistry, Math, Physics and General Studies were combined, using EM (ExpectationMaximization) imputation to replace missing values, and then extraction of the first principal component. A similar process took place for SQA qualifications, combining the five highest Highers Plus grades, highest Advanced Highers grade, Highers Plus grade at Biology, Chemistry, Physics and Math, and Advanced Higher grade at Biology, Chemistry, Math and Physics, with EM imputation for missing values and extraction of the first principle component. We refer to these measures here as “EducationalAttainmentGCE” and “EducationalAttainmentSQA”.
The UCLMS cohort study
The sampling frame for this study [4] consisted of 729 students entering the clinical course (year 3) at University College London Medical School (UCLMS) in autumn 2005 (n = 383) and 2006 (n = 346), of whom 621 (85.2%) had studied basic medical sciences (BMS) at UCLMS, and all but one of the remaining 108 students had studied BMS at Oxford or Cambridge.
Students had entered medical school between 2001 and 2004, different times since entry reflecting personal circumstances, exam failure or intercalated degrees. Finals were mostly taken in 2007 and 2008, with some students taking them later, again for various reasons. Examination results were available for students taking first and second year exams at UCL, and for all third, fourth and fifth year examinations. Performance was summarized by the medical school as a total overall score. Because students entered the medical school in different years, comparability was ensured by converting all scores to zscores by year.
Alevels were taken by 669 students and scored as the best three grades attained, on the basis of A = 10, B = 8, C = 6, D = 4 and E = 2 (A* grades had not yet been introduced). A total of 62.5% of students achieved the maximum of 30 points, with 16.9%, 12.3%, 3.1%, 2.2% and 2.9% achieving 28, 26,24, 22 or 20 (or fewer) points. GCSE results were known for 599 students, students taking an average number of 10.04 GCSEs and achieving a mean of 53.6 points (SD 7.84; A* = 6, A = 5, B = 4, C = 3, D = 2, E = 1).
Of the original 729 students, 252 (34.6%) had taken MRCP(UK) Part 1 by October 2012, 122 (16.7%) had taken Part 2, and 59 (8.1%) had taken PACES, with Parts 1, 2 and PACES passed by 80.9%, 90.2% and 76.3%. Performance was obtained from the records of MRCP(UK) Central Office, based on a ‘History file’ extracted on 12 October 2012. For Part 1 and Part 2, marks are expressed as percentage points above or below the pass mark (which varies from diet to diet). For PACES/nPACES, marks were expressed as a percentage relative to the pass mark, as in a previous study [28]. All MRCP(UK) marks are analyzed in relationship to the mark at the first attempt, which has been shown to be a good indicator of overall performance [29]. None of the cohort was on the specialist register at the time of followup.
The 1990 cohort study
The sampling frame was the 6,901 applicants to English medical schools in the autumn of 1990 for admission in 1991 (St. Mary’s Hospital Medical School; UMDS (United Medical and Dental Schools of Guy’s and St. Thomas’s); UCMSM (University College and Middlesex School of Medicine), University of Sheffield, and University of NewcastleuponTyne) [25]. Applicants who entered any UK medical school have been followed up, in their final medical school year (mostly in 1996 or 1997 [30, 31], in their preregistration house officer (PRHO) year (mostly in 1997 or 1998 [32, 33]), in 2002, when the doctors were mostly working as GPs or Specialist Registrars [34], and again in 2009 [35]. UK medical schools provided information on preclinical/basic medical science course outcomes in 1993 to 1994 and on finals in 1996 to 1997 to ascertain the outcome in clinical years. Basic medical science performance was expressed on a fourpoint ordinal scale, and finals performance on a binary scale.
Alevel results were scored in the standard way. The study took place as Olevels were being replaced with GCSEs, and separate scores were derived for mean Olevel grade or mean GCSE grade, and expressed as zscores. Applicants who attended for interview at St. Mary’s, UMDS or Sheffield took an abbreviated version of the AH5 test of intelligence [19] (aAH5), which was timed. The aAH5 was entirely for research purposes, and results were not made available to the medical schools concerned.
GMC numbers for all graduates were identified, and subsequently used to link the data with the GMC’s LRMP (List of Registered Medical Practitioners), and with MRCP(UK) results, which were scored in a similar way to that in the UCLMS Cohorts with minor differences [4].
The 1985 cohort study
The 1985 cohort study [24] consisted of 2,399 individuals who applied to St. Mary’s Hospital Medical School in the autumn of 1985 for entry to medical school in October 1986. St. Mary’s was a popular choice with applicants with 24.7% of all medical school applicants, including it as one of their five medical school applications. Entrants to any UK medical school were followed up, and included 22.7% of all entrants to UK medical schools in that year [24]. Alevel and Olevel results of candidates were recorded. UK medical schools provided information on performance on the basic medical science course, recorded on a fourpoint scale. For students taking finals in the (then) constituent medical schools of the University of London, which had a common, shared examination system, details of performance in all assessments were collected and expressed as a single overall score [36]. Information on MRCP(UK) was not available, but there was information about which doctors were in the GMC’s Specialist Register.
The 1980 cohort study
The 1980 Cohort Study, which was the first and hence smallest of the three cohort studies at St. Mary’s Hospital Medical School, studied all 1,361 individuals who in the autumn of 1980 applied to study medicine at St. Mary’s. The 519 entrants to any UK medical school were followed up [23, 37, 38], and represented 12.9% of all UK medical school entrants in 1981. UK medical schools provided information on basic medical science performance on a fourpoint scale [39]. For students taking the common finals examinations of the University of London, detailed performance measures were available, as with the 1985 cohort study [36].
The Westminster cohort study
The Westminster Study was initiated by Dr Peter Fleming, who studied the 511 students entering the clinical course of the Westminster Medical School between 1975 and 1982 [3]. The Westminster only ran a clinical course, and basic medical sciences had been studied elsewhere, so that students entered medical training between 1972 and 1980. Outcome on the clinical course was recorded on a fourpoint scale. Alevel results were available for the entrants, and all students also took a timed version of the full AH5 test. Information on which doctors were on the specialist register was available.
Statistical analysis
Conventional statistical analyses used SPSS 20.0. (International Business Machines Corporation, Statistical Package for the Social Sciences, Armonk, New York, USA) Special purpose programs were written in Matlab to calculate correlations corrected for rightcensoring, as well as tetrachoric and polychoric correlations for grouped data. In addition the HunterSchmidtLe (HSL) model of constructlevel predictive validity extended for censored and grouped data was also programmed in Matlab. All Matlab programs used the DRAM adaptation of MCMC [40], available from Dr Marko Laine of the University of Helsinki (see helios.fmi.fi/~lainema/mcmc/, helios.fmi.fi/~lainema/mcmc/mcmcstat.zip and helios.fmi.fi/~lainema/dram/). MCMC analyses typically used a chain length of 5,000 or 10,000 with parameter estimates based on the final 2,000 items in the chain, means and standard deviations being used as the estimate and the standard error of parameters, with 5% confidence intervals estimated as the 2.5^{th} and 97.5^{th} percentiles of the actual values in the chain.
The MCMC program used to estimate constructlevel predictive validity estimated seven parameters (mean and SD of the predictor in entrants, mean and SD of the predictor in applicants, mean and SD of the outcome measure in entrants, and the correlation between the predictor and the outcome), in each case taking into account rightcensorship of measures (for continuous measures such as Alevels), or nonnormality and reduced numbers of ordinal outcomes, as for some outcome measures (such as fourpoint summaries of BMS performance). The correlation and the SD estimates of the predictor in applicants and entrants, as well as the two reliabilities, were then entered into the HSL formula [8]. The MCMC algorithm typically had a chain length of 5,000, with estimates derived for the last 2,000 iterations. Estimates were plotted against chain number to ensure that equilibrium had been reached. The HSL formula was calculated separately for each step in the chain, and hence standard errors could be calculated for the constructlevel predictive validity, selection ratio and other parameters.
Metaregression of the constructlevel predictive validities was carried out using the Moderator_r macro (Meta_Mod_r.sps) for SPSS of Field and Gillett [41]. All analyses used random effects regression analysis, and hence are generalizable to other populations than those used in the present analyses.
All confidence intervals (CI) are 95% confidence intervals, whatever the method of calculation.
Ethics
The Chair of the UCL Ethics Committee has confirmed that studies, such as the present ones, are exempt from needing formal permission from the Committee, being included under sections c and f of the exemptions (see http://ethics.grad.ucl.ac.uk/exemptions.php).
Results
Descriptive statistics for predictoroutcome correlations and criterionrelated construct validities
Predictoroutcome correlations  Criterionrelated construct validities  

N participants  Pearson  Corrected*  r  Equivalent N  
N studies  Mean (Range)  Mean (Range)  Mean (Range)  Mean (Range)  Mean (Range)  
Predictor  
Alevels  22  920 (R 55; 3,096)  .180 (R .041; .306 )  .231 (R .053; .415)  .634 (R .147; .943)  61 (R 8; 245) 
ASlevels  1  1911  .182  .228  .458  266 
GCSEs/Olevels  20  849 (R 52; 2,657)  .162 (R .026 ; .269)  .176 (R −.045; .273)  .336 (R −.079; .626)  231 (R 16; 1,271) 
Highers  1  777  .001  .076  .107  336 
‘HighersPlus’  1  771  .143  .180  .292  265 
Advanced Highers  1  735  .345  .358  .506  247 
Ed. Attainment GCE  1  2768  .312  .347  .923  745 
Ed. Attainment SQA  1  722  .419  .425  .623  317 
Aptitude tests (AH5, UKCAT)  9  934 (R 156; 4,841)  .132 (R .037; .276)  .152 (R .045; .260)  .228 (R.062; .449)  445 (R 62; 2,720) 
Outcome  
BMS first year  15  1521 (R 542; 4,841)  .207 (R −.001 ; .419)  .248 (R .076; .425)  .498 (R .107; .943)  517 (R 24; 2,720) 
BMS overall  9  1152 (R 502; 3,096)  .174 (R .037; .282)  .215 (R .053; .394)  .491 (R .065; .903)  203 (R 10; 513) 
Finals  11  786 (R 314; 2,413)  .187 (R .051 ; .306)  .222 (R .080; .328)  .488 (R.097; .871)  136 (R 10; 389) 
MRCP(UK) Pt1  5  492 (R 202; 957)  .192 (R .126; .245)  .221 (R .143; .308)  .456 (R .168; .692)  107 (R 32; 209) 
MRCP(UK) Pt2  5  363 (R 98; 753)  .205 (R .085 ; .299)  .227 (R .071; .217)  .442 (R .326; .743)  44 (R 12; 80) 
MRCP(UK) Clinical  5  277 (R 52; 597)  .141 (R .058; .236)  .144 (R .071; .217)  .317 (R .147; .627)  40 (R 10; 81) 
On Specialist Register  9  984 (R 393; 2,664)  .084 (R .026; .419)  .113 (R −.045; .249)  .367 (R −.079; .803)  126 (R 8; 2,720) 
Cohort  
Westminster  4  470 (R 454; 486)  .169 (R .146 ; .190)  .226 (R .188; .249)  .565 (R .386; .803)  49 (R 17; 96) 
1980 cohort  8  449 (R 314; 562)  .164 (R −.026; .306)  .192 (R −.046; .315)  .457 (R −.079; .864)  73 (R 14; 178) 
1985 cohort  6  643 (R 347; 851)  .164 (R .066 ; .240)  .187 (R .102; .253)  .566 (R .214; .903)  98 (R 8; 289) 
1990 cohort  18  1234 (R 156; 3,096)  .133 (R .037; .276)  .157 (R .045; .280)  .357 (R .062; .692)  190 (R 42; 513) 
UCLMS cohorts  12  362 (R 52; 668)  .218 (R .058; .299)  .261 (R .071; .415)  .475 (R .147; .743)  96 (R 10; 346) 
UKCAT12  9  1,938 (R 722; 4841)  .198 (R −.001; .419)  .232 (R .076; .425)  .467 (R .107; .943)  688 (R 25; 2720) 
All construct validities  57  935 (SD = 956) (R 52; 4841)  .171 (SD = .092) (R .−026; .419)  .203 (SD = .101) (R −.045; .425)  . 450 (SD = .248) (R −.079; .943)  213 (SD = 396) (R 8; 2720) 
Calculation of constructlevel predictive validity is more complex than that of calculating predictoroutcome correlations. The basic method of Hunter et al. for indirect range restriction requires the estimation of five parameters: i) the reliability of the predictor measure in applicants; ii) the reliability of the outcome measure in entrants; iii) the predictoroutcome correlation in entrants; iv) the standard deviation of the predictor measure in applicants; and v) the standard deviation of the predictor measure in entrants.
The standard deviations in applicants and entrants are used to calculate the ‘selection ratio’, the SD of the predictor in entrants as a proportion of the SD of the predictor in all applicants, smaller values indicating a greater extent of selection. A selection ratio of one means that entrants have the same variability as applicants (and so, in effect, little or no selection is taking place on the predictor). The mean selection ratio is .732, meaning that entrants indeed have a smaller range of scores than do applicants. The selection ratios differ, however, for different predictors. There is strong selection on the GCE qualifications of Alevels (.656), ASlevels (.667), and GCSEs/Olevels (.676), with less strong selection on the SQA qualifications of Highers (.896), ‘Highers Plus’ (.814), and Advanced Highers (.941). The two derived measures from the UKCAT12 study [21], Educational Attainment based on GCE results and SQA results, have stronger selection than their component measure (GCE .358; SQA .766), with particularly strong selection on GCEs. The implication is that admissions tutors are making holistic judgments which implicitly combine a wide range of information from different sources. The selection ratio for aptitude tests is only well assessed in the UKCAT12 study, where the ratio is .775, indicating fairly strong selection, although not as strong as for Alevels.
Selection ratios were not available for the Westminster Cohort or the UCLMS cohorts. Modeling suggested that selection ratios differed little by cohort or by outcome variable, but did show some variation according to the predictor variable. Median values of .664, .690 and .750 were used for Alevels, GCSEs/Olevels and aptitude tests in these cohorts.
Estimation of reliabilities was not always straightforward, particularly for measures such as the three best Alevels, the standard measure of Alevel achievement. Estimates of the reliability of Alevels, ASlevels, GCSEs, Highers, Highers Plus and Advanced Highers are generally not available [42]. The calculation of reliabilities from raw data, which is not simple, is described in the statistical appendix (Additional file 1), taking rightcensorship into account in each case. The reliability of UKCAT is published in its annual reports [20, 43, 44], and the reliability of AH5 was based on the values described in the manual. Estimates of outcome measures are also not straightforward. A metaanalysis of gradepoint averages finds a reliability of about .84 [45], and that, along with other data, forms the basis for our estimates described in the statistical appendix (Additional file 1). A special problem in some cases is that outcome measures have only three or four ordinal categories (for example, Fail, Resit, Pass, Honors), or in the case of being on the Specialist Register are binary. Methods equivalent to tetrachoric and polychoric correlations are described in the statistical appendix (Additional file 1). Estimates of the reliability of MRCP(UK) Parts 1 and 2 have been published [46, 47], although they are based on all candidates, rather than UK graduates, and have, therefore, been corrected. A reliability estimate for MRCP(UK) Part 2 Clinical Examination (PACES) is also available [48].
The reliabilities of the various predictors and outcomes are summarized in the Additional file 1: Table S1 and S3. Reliabilities sometimes need to be corrected for rightcensorship. Taken overall the predictors had an average reliability of .815, and the outcome measures had a mean reliability of about .834. Reliabilities were not available for all measures, in which case estimates were used (see the statistical appendix (Additional file 1) for details).
Metaregression
In total, 57 constructlevel predictive validity coefficients and their associated confidence intervals were available, based on a variety of summative outcome measures. Descriptive statistics are given in Table 1 for the simple (Pearson) predictoroutcome correlations, the corrected predictoroutcome correlations, and the constructlevel predictive validities, broken down in each case by predictor, outcome and cohort. Constructlevel predictive validity coefficients, which take into account reliability, range restriction and rightcensorship, are substantially larger (mean = .450) than are the corrected correlations (mean = .203), which in turn are larger than the simple, unadjusted predictoroutcome correlations (mean = .171). All of the participants are used for calculating constructlevel predictive validities, as in calculating the simple predictoroutcome correlations (that is, the mean number of participants is 935). However, although constructlevel predictive validities are, in effect, correlations, their standard errors cannot be calculated on the basis of the actual N in a study. Instead, standard errors of the constructlevel predictive validities were estimated from the variability in the chain of the MCMC algorithm (see statistical appendix (Additional file 1)). The constructlevel predictive validities are correlations and, hence, can be entered into a metaregression. However, metaregression normally requires r and a value of N to calculate the standard error of correlations before combining them. Since the standard errors of the constructlevel predictive validities have been estimated in our case by the MCMC algorithm, we have used those standard error estimates to backcalculate, using the standard formula for the standard error of a correlation, what the “equivalent N” would have been to have resulted in the actual standard error which the MCMC algorithm found. The equivalent N, which is entered into the metaregression along with the constructlevel predictive validity, is shown in Table 1 and it is always smaller than the actual N, showing how constructlevel predictive validities are estimated much less reliably than conventional correlations. ‘Equivalent N’ has a mean of 218, and so, on average, equivalent N is about one quarter of actual N, meaning that the standard errors are about twice as large as that expected based on actual N, the difference arising because constructlevel predictive validities incorporate uncertainty from several different sources.
The metaregression analysis of constructlevel predictive validity began with a series of exploratory analyses. A categorical effects model with all of the Predictors, Outcomes and Cohorts which has 8 + 6 + 5 = 19 parameters (which is large compared to the 57 data points), found highly significant differences between Predictors (chisquare = 114.4, 8 df, P < .001), but not between Outcomes (chisquare = 4.66, 6df, P = .588) or Cohorts (chisquare = 5.30, 5 df, P = .380). In order to reduce the number of parameters, Cohort and Outcome were expressed as continuous variables (that is, single degrees of freedom), in terms of YearOfEntry to medical school (1975, 1981, 1986, 1991, 2002 and 2008 for the Westminster, 80, 85 and 90 cohorts, UCLMS and UKCAT12 cohorts), and YearOfTraining (BMS1 = 1, BMSoverall = 2; Finals = 5; MRCP(UK) Parts 1, 2 and Clinical = 8, 9 and 10 , and Specialist Register = 12). A model with Year of Entry and Year of Training as covariates, and Predictor as a categorical measure found significant effects for Predictor (chisquare = 126.0, 8 df, P < .001), the effect of YearOfTraining was almost significant (b = −.016, t = −1.91, 45 df, P = .063), and would have been significant with a onetailed test, the effect being in the obvious direction (P = .032). The effect of YearOfEntry was not significant (b = −.003, t = −.737, 45 df, P = .465). Addition of a term for a YearOfTraining x YearOfEntry interaction also was not significant (t = −.599, 44 df, P = .553). Constructlevel predictive validity differs therefore between different predictors, and perhaps between Outcomes (outcomes earlier in training having higher validities than later outcomes), but there was no evidence for a YearOfEntry (Cohort) effect, or for a YearOfEntry × YearOfTraining interaction.
Summary of construct validity coefficients
Outcome  Predictor  

Alevels  GCSEs/Olevels  Aptitude tests  
First year BMS  .809 n = 3 (CI .501; .935)  .332 n = 3 (CI .024; .583)  .245 n = 1 (CI .207; .276) 
BMS overall  .744 n = 4 (CI .518; .872)  .361 n = 4 (CI .305; .413)  .065 n = 1 (CI −.049; .180) 
All BMS  .772 n = 7 (CI .627; .865)  .338 n = 7 (CI .205; .459)  .164 n = 2 (CI −.031; .347) 
Finals  .625 n = 5 (CI .449; .754)  .400 n = 4 (CI .274; .513)  .226 n = 2 (CI −.093; .503) 
All Undergraduate except first year BMS  .684 n = 9 (CI .561; .778)  .379 (n = 8) (CI .316; .439)  .147 (n = 3) (−.065; .346 ) 
All Undergraduate  .723 n = 12 (CI .616; .803)  .359 n = 11 (CI .255; .455)  .181 n = 4 (CI .055; .302) 
MRCP(UK) Part 1 (written)  .661 n = 2 (CI .523; .765)  .433 n = 2 (CI .098; .680)  .168 n = 1 (CI .044; .308) 
MRCP(UK) Part 2 (written)  .502 n = 2 (CI −.030; .812)  .372 n = 2 (CI .153; .555)  .358 n = 1 (CI .174; .559) 
MRCP(UK) Clinical  .303 n = 2 (CI .010; .547)  .498 n = 2 (CI .068; .772)  .226 n = 1 (CI .007; .422) 
All MRCP  .506 n = 6 (CI .301; .666)  .447 n = 6 (CI .300; .573)  .226 n = 3 (CI .108; .339) 
Specialist Register  .627 n = 4 (CI .450; .756)  .119 n = 3 (CI −.044; .276)  .258 n = 2 (CI .171; .605) 
All postgraduate  .556 n = 10 (CI .426; .663)  .316 n = 9 (CI .148; .466)  .243 n = 5 (CI .090; .385) 
All undergraduate and postgraduate  .656 n = 22 (CI .574; .726)  .342 n = 20 (CI .258; .420)  .208 n = 9 (CI .124; .289) 
Constructlevel predictive validity of Alevels
There were 22 constructlevel predictive validities for Alevels. Overall Alevels had a constructlevel predictive validity which was significantly different from zero (mean = .656; CI .572 to .727). There was no evidence of a YearOfEntry effect or of a YearOfEntry × YearOfTraining interaction, but the YearOfTraining effect was significant (b = −.040, t = −2.267, 19 df, P = .035), with no evidence of additional differences between Outcomes after YearOfTraining was taken into account. Table 2 shows that the constructlevel predictive validity of Alevels is greatest for first year BMS exams, and declines through undergraduate and postgraduate years, although it is significant in all cases.
Constructlevel predictive validity of GCSEs/Olevels
Twenty constructlevel predictive validities were available for GCSEs/Olevels, with the overall constructlevel predictive validity being highly significant (mean = .342; CI .258 to .420). YearOfTraining showed no significant effect on its own (t = −.834, 17 df, p = .416) as neither did YearOfEntry (t = .002, 17 df, P = .738). Finally, although neither Linear YearOfEntry and Linear YearOfTraining was significant when both were in the model, when combined with the linear × linear interaction, while YearOfEntry was not significant (P = .166), but YearOfTraining was just significant (b = −5.62, t = −2.14, 15 df, P = .049), and the interaction was also just (P = .049). Taken together there is a suggestion that constructlevel predictive validity of GCSEs/Olevels might decline a little as training progresses and in more recent years, but the effects are unclear.
Constructlevel predictive validity of aptitude tests
Nine constructlevel predictive validities were available for aptitude tests, two from the Westminster Cohort (AH5), six from the 1990 Cohort (aAH5), and one from UKCAT12 (UKCAT total score), with a highly significant effect overall (mean = .208; CI .113 to .299, t = 4.89, 9df, P < .00001). Assessed separately, YearOfEntry and YearOfTraining had no effect (P = .300 and P = .565), although once again when YearOfEntry, YearOfTraining and their interaction were included there were almost significant effects of YearOfTraining (P = .081) and the interaction (P = .081).
Constructlevel predictive validity of Alevels, GCSEs/Olevels and Aptitude tests for Undergraduate performance
Alevels, GCSEs/Olevels and Aptitude tests all show significant constructlevel predictive validities overall. Here we compare their constructlevel predictive validities for the 27 assessments in the undergraduate course, be it basic medical sciences or clinical assessments. The three predictors are significantly different in their constructlevel predictive validity (Chisquare = 40.92, 2df, P < .001), and as can be seen in Table 2, the constructlevel predictive validity for Alevels is .723 (CI: .616 to .803), that for GCSEs/Olevels is .359 (CI: .255 to .455) and .181 (CI: .055 to .302) for aptitude tests.
Constructlevel predictive validity of Alevels, GCSEs/Olevels and Aptitude tests for Postgraduate performance
Constructlevel predictive validity was available for 24 postgraduate outcomes. Alevels, GCSEs/Olevels and aptitude tests showed highly significant differences (chisquare = 9.57, 2df, P = .008), and Table 2 shows that Alevels had the highest constructlevel predictive validity (mean = .556; CI: .426 to .663), followed by GCSEs/Olevels (mean = .316; CI: .148 to .466) and aptitude tests (mean = .243; CI: .090 to .385). Pairwise comparison showed that Alevels had higher constructlevel predictive validity than GCSEs/Olevels and Aptitude Tests (chisquare = 5.535 and 11.14, 1 df, P = .019 and < .001), but GCSEs/Olevels were not significantly different from Aptitude Tests (chisquare = .321, 1 df, P = .571).
Prediction of MRCP(UK) vs Specialist Register
Postgraduate performance was assessed by two rather different outcomes, performance on MRCP(UK) and entry to the Specialist Register. As we have discussed in the paper on the Academic Backbone [4], entry to the Specialist Register is potentially a different form of outcome measure to MRCP(UK) which consists of examination results. We have therefore carried out an analysis comparing the 15 validities based on MRCP(UK) results with 9 validities based on entry to the Specialist Register, across all Predictors (AH5, n = 5; Alevels, n = 10; and GCSEs/Olevels, n = 9). Although there were clear differences in construct validities between the different predictors (chisquare = 10.09, 2df, P = .006), there were no significant differences between outcomes coded as MRCP(UK) or Specialist Register (chisquare = 1.003, 1df, P = .317). It can be concluded that although MRCP(UK) and Specialist Register may be different conceptually, they are predicted in equivalent ways to one another by earlier measures of secondary school attainment and aptitude.
Comparing prediction of undergraduate and postgraduate performance
Constructlevel predictive validity of Alevels, GCSEs/Olevels and aptitude tests for first year Basic Medical Science performance
Predicting firstyear performance is particularly important, as although a number of students fail and leave medical school then, those who only just get into the second year, with marks little above those who have failed, tend to continue on to the end of the course, and into practice, often struggling for much of the time [49–51]. As a result, constructlevel predictive validities were analyzed for just those assessments. The metaregression contained three relevant constructlevel predictive validities for Alevels, .709 (.467 to .880) in the 1980 cohort, .672 (.550 to .775) in the UCLMS cohorts, and .943 (.890 to .980) in UKCAT12, the latter being by far the largest study. The metaanalytic combined estimate for Alevels is .809 (n = 3; CI: .490 to .937), with no evidence of heterogeneity (chisquare = 2.184, 2 df, P = .335). The combined estimate for GCSEs/Olevels was .332 (n = 3; CI: .024 to .583). There was only one constructlevel predictive validity of an aptitude test for first year results, in the UKCAT12 cohort, it being .245 (CI: .207 to .276).
ASlevels, Highers, Advanced Highers and educational attainment measures
SQA qualifications were only available for the UKCAT12 study, and hence their constructlevel predictive validities are best compared with those for Alevels, ASlevels and GCSEs in UKCAT12, which were .943 (CI: .890 to .980), .458 (CI: .359 to .449) and .110 (CI: .058 to .167). Highers, ‘Highers Plus’ and Advanced Highers had constructlevel predictive validities of .107 (CI: .010 to .202), .293 (CI: .189 to .409) and .507 (CI: .429 to .614), none of which compared with that for Alevels, and only Advanced Highers was comparable with ASlevels. In the UKCAT12 study, two derived measures were also extracted, which we called EducationalAttainmentGCE and EducationalAttainmentSQA, and which were composites derived from all of the educational qualifications. The constructlevel predictive validity for EducationalAttainmentGCE was also high at .923 (CI: .912 to .933) and that for EducationalAttainmentSQA was higher than its component parts at .623 (CI: .541 to .676).
Discussion
Any measure, be it physical, biological or behavioral, has errors due to unreliability. The measures used in medical student selection also suffer from range restriction, and in addition, as Figures 3 and 4 show, many of the educational measures show rightcensorship, typically due to grade inflation, with many candidates being at the ceiling. In consequence, selection measures such as Alevel grades often seem to show very small correlations with outcome measures, which typically assess medical school examination performance. A typical predictoroutcome correlation in the present study is .171, with the implication that only studies with nearly 300 students would have a 90% chance of finding a significant correlation between a typical predictor and a typical outcome. Such small correlations, particularly if nonsignificant, are often erroneously treated as meaning that selection variables are ineffective or of no consequence.
Actual predictoroutcome correlations are often far smaller than constructlevel predictive validities (truescore correlations). That difference matters because, as Hunter and Schmidt [52] have emphasized, “what we are interested in scientifically is the constructlevel correlation” (p.16). Rubin [53] has emphasized that “we really care about the underlying scientific process that is generating [the] outcomes that we happen to see  that we, as fallible researchers, are trying to glimpse through the opaque window of imperfect empirical studies” [53] (p.157).
In a perfect world there would be perfect measures of academic performance at medical school and perfect measures of educational attainment and intellectual aptitude in applicants applying to medical school and entrants to medical school would be a random sample of those applying. Given that, it would be straightforward to determine how well selection measures work, and whether the measures in use are sufficient or perhaps others, assessing other characteristics or traits, are also needed.
Constructlevel predictive validities estimate the correlations that would pertain in a world permitting perfectly accurate and complete measurement, and in so doing make several things possible. First, predictors can be compared with one another without reliabilities and range restriction confounding the differences. Second, constructlevel predictive validities also provide a perspective on the limits of what current measures could, in principle, do if they were not subject to measurement error or other problems. That is central to the difficult question of whether current measures should be refined, replaced or supplemented by other measures. Finally, because they attempt to consider perfect measures, constructlevel predictive validities also throw into sharp relief the theoretical imperfection of even the best measures that we might have, showing their flaws and their conceptual failings. The end result is an assessment of what the measures can in principle do.
Comparing predictors
Comparing the main predictors, particularly for undergraduate examinations, it is clear that Alevels are the best predictor (.723; CI: .616 to .803), followed by GCSEs/Olevels (.359; CI: .255 to .455), with intellectual aptitude tests predicting much less well, albeit significantly differently than zero (.181; CI: .055 to .302). Other predictors are mostly present only in the UKCAT12 study and, hence, it is more difficult to generalize about them. However, it does appear that SQA qualifications have a lower constructlevel predictive validity than GCE qualifications, with Highers having a very low validity. The lower constructlevel predictive validity of SQA qualifications is important because a simple comparison of predictoroutcome correlations suggests that SQA examinations perform better than GCE examinations [21, 27]. That the constructlevel predictive validities are the other way around is a result of SQAs having higher reliabilities and higher selection ratios (see Table 1), which results in relatively lower constructlevel predictive validities^{a}. The two composite measures of EducationalAttainmentGCE and EducationalAttainmentSQA, despite having higher correlations with medical school outcome than their component scores, had similar constructlevel predictive validities to Alevels and Advanced Highers and are, therefore, probably not providing additional information over the simpler measures concerning constructlevel predictive validity, although they may be better for those wishing to predict performance within medical school rather than for selection purposes.
Predicting first year BMS examinations
In many ways the most important outcome in terms of medical student selection is performance in basic medical sciences examinations in the first year, as the end of the first year is mostly when failing medical students either have to leave the course or are required to repeat a year. Predicting firstyear performance is, therefore, particularly important. The metaregression contained three relevant constructlevel predictive validities, and the metaanalytic estimate for Alevels of .809 (CI: .501 .935) is high, and is higher than for GCSEs/Olevels (.332; CI: .024 to .583) and for the sole aptitude test, UKCAT (.245; CI: .207 to .276).
The Academic Backbone
Educational qualifications predict performance better in assessments earlier in training rather than later. That is hardly surprising, and to some extent reflects what we have elsewhere called the Academic Backbone [4], performance at each stage being built upon performance at previous stages. If educational qualifications predict, say, MRCP(UK) less well than they predict finals, that is in part because finals themselves are part of the prediction of performance at MRCP(UK). Likewise, GCSEs may not predict outcomes well, but they are good at predicting Alevels, which is perhaps their main role [54].
How much can Alevels predict?
Using the metaanalytic first year BMS constructlevel predictive validity estimate of .809, then 65% of the total, true variance in first year examination performance is accounted for by Alevel performance, which clearly makes Alevels an important part of medical student selection. The estimate of .809 may itself be an underestimate, in part because, as shown elsewhere [27], the measure we have called “EducationalAttainmentGCE” predicts outcome better than Alevels alone. That may be because Alevels are not always of equivalent difficulty [55], and better students may choose to take harder Alevels. The measure also includes General Studies which, contrary to popular belief, seems to be a separate and independent predictor of medical school performance [21]. Considering just Alevels, for which 65% of first year exam variance seems to be explained, the important corollary is that 35% of first year performance must be explained by something other than Alevels. Most of that 35% is unlikely to be assessed directly or indirectly by GCSEs or aptitude tests since both of those measures have little incremental validity over Alevels [21]. The most likely origin is in personality, motivation or other individual difference factors, although part of the explanation may also lie in the random, unpredictable events that occur in everyday life, including problems with peers, money, relationships, family or whatever, that are inherently unpredictable but can impact substantially on medical school performance, particularly in students who may recently have left home for the first time. Many such events cannot be predicted when selection takes place and, hence, any variance due to them cannot be taken into account by educational attainment or its correlates. Similar events which have happened before Alevels and selection could also be involved, lowering attained Alevel grades, and when the impact of those events subsequently diminishes then students overperform relative to what their Alevels might seem to have predicted. Whatever the nature of the missing variance, a major challenge has to be identifying the causes or the correlates of that additional variance, as it might account for a quarter or a third of the variance in first year medical school performance. In addition, because impacts on first year performance can subsequently be multiplied through the Academic Backbone with the accumulation of ‘medical capital’ [4], so small over or underachievements early in a career can potentially multiply as the medical course continues.
The stability of constructlevel predictive validity of educational achievement measures in the cohorts
The present studies took place in six cohorts of students who entered medical school from 1972 through to 2009. A remarkable finding is that all of the qualifications, be they Alevels, GCSEs/Olevels or aptitude tests, seem to predict at the same level across the entire temporal range of the cohorts. It might have been thought that changes in the nature of examinations such as Alevels, which have become less heavy on facts in recent years, might have altered their constructlevel predictive validity. Medical school courses and assessments have also have become less fact heavy, with assessments now including OSCEs and other assessments of practical skills, communicative ability and so on, but despite that the predictive validity of the various qualifications seems to have remained equivalent.
The role of GCSEs/Olevels
A recurrent theme in student selection is that GCSEs or Olevels may be better predictors of outcome than Alevels. As long ago as a GMC conference in 1973 it was reported that, “performance in the Second MB examination correlated better with GCE O level than with A level results” (p.7), with speculation that, “the O level correlation with future performance might be more accurate than the A level results, because at the latter stage the ‘heat was turned on’ for University entrance. [As a result] the A level results were based on factual knowledge and did not necessarily depend on greater intellectual capacity” [10] (pp. 7–8). The current metaanalysis provides no support for that argument in the undergraduate course, but it is striking that Alevels, like GCSEs/Olevels and aptitude tests, have similar constructlevel predictive validities in both undergraduate and postgraduate assessments. Elsewhere we have noticed hints that GCSEs/Olevels may have additional predictive incremental value for predicting finals after taking Alevels and BMS performance into account [4], with the possibility that they are assessing something separate from the academic skills assessed in Alevels.
Aptitude tests as predictors
The two tests of intellectual aptitude, UKCAT and AH5, predict undergraduate and postgraduate performance to similar extents with an overall constructlevel predictive validity for undergraduate performance of .181, which is relatively low and is appreciably lower than for Alevels (.723) and GCSEs/Olevels (.359). In addition the incremental validities for AH5 [3] and UKCAT [21] are small once Alevels have been taken into account. UKCAT and similar tests may have some role to play in selection when there is strong range restriction on Alevels and other attainment tests, although the Sutton Trust reported that the SAT Reasoning test did not differentiate outcome in highachieving university entrants with AAA grades [56] (pp.3738). The UKCAT consortium is also currently piloting noncognitive tests which may have additional predictive ability.
What is the medical school applicant pool?
Our analyses have taken the pool of medical school applicants as being those who chose to apply, many of whom eventually attain quite low Alevels and other grades. Applying to medical school though is a choice, and there is no reason why candidates with substantially lower grades might not also choose to apply, particularly if medical schools were to suggest that there was a realistic chance that they might be admitted. The estimate of constructlevel predictive validity for, say, Alevels is, therefore, an estimate given the applicants who actually applied. Were medical schools to suggest that applicants might be accepted with, say, the minimum matriculation grades of EE, then the variance in Alevel grades of candidates would increase, resulting in the constructlevel predictive validities being yet higher. Taking the concept to its extreme, were entrants of any intellectual ability to be allowed to enter, including those with minimal grades at GCSE (see the population distribution elsewhere [54]), then the constructlevel predictive validity of educational attainment would probably rise close to one, as it also would were applicants to be admitted across the entire population range of intellectual ability.
What happens to students who enter medical schools with substantially lower Alevel grades?
One of the most interesting educational initiatives in UK medical education is the Extended Medical Degree Programme (EMDP) at King’s College, London [57–60], which admits students from lowachieving secondary schools who have Alevel grades substantially below those normally required for medical school admission. Average grades initially were CCC (more recently rising to BBC), with BCC currently being the standard offer [61]. The study claimed that, “medical students can succeed without AAB at A level if these results were obtained from a low achieving [secondary] school” [57] (p.1113). The claim would be supported by the finding in the UKCAT12 study that students attaining Alevels from underachieving secondary schools subsequently do better at medical school [21], although the effect is relatively small (and the much larger HEFCE study found it to be of the order of one Alevel grade, so that ABB from a lower achieving secondary school was equivalent to AAB from a higher achieving secondary school [62]). The effect of a low achieving secondary school is probably therefore too small to account for the claims made for the EMDP program, and potentially, therefore, is a challenge to the predictions made from constructlevel predictive validity.
Formal statistical analyses have however suggested that EMDP students have a performance in finals which is about .73 (CI: .38 to −1.09) standard deviations below that of students on the fiveyear program [63]. In the present study, the metaanalytic estimate of constructlevel predictive validity for finals in relation to Alevels is .625 (n = 5; CI: .449 to .754). Using a reliability of .905 for finals and .867 for Alevels (from the UKCAT12 study), then the attenuated AlevelsFinal correlation can be estimated at .553. Alevels in the UKCAT12 applicants have a decensored mean of 29.01 (SD = 5.89), so that students with grades BBB, BBC, BCC and CCC are −.85, −1.19, −1.53 and −1.87 SDs below the mean without taking attenuation into account. Given the estimated Alevelsfinals correlation of .553 they would be expected to score −.47, −.66, −.85 and −1.04 SDs below the mean in the finals assessment. The expected average for students with grades CCC to BBB is therefore about −.75, which is very close to the actual value of −.73. Were they admitted, entrants with grades of DDD or EEE would be expected to have mean scores −1.60 and −2.16 SDs below the mean.
In BMS examinations where conventional students show a retention rate of 97% (3% failing), EMDP students showed retention rates of 90% (10% failing) [57]. Retake rates for BMS exams are 15% in conventional students but 32% in EMDP students, with “A level chemistry and biology grades … of the EMDP students showing significant correlation with marks in the first year examinations” [57]. A variant on the calculation for finals can be used to predict these rates. Using a reliability for Alevels of .867, a reliability for a continuous overall BMS result of .904 (based on the UCLMS cohorts), and a metaanalytic constructlevel predictive validity of .744 (n = 4; SD = .518 to .872), the attenuated predictoroutcome correlation is calculated as .659. A failure rate of 3% for conventional students implies that the cutoff is −1.88 SDs below the mean, and a retake rate of 15% implies a cutoff of −1.03 SDs. Failure rates for students with entry grades of BBB, BBC, BCC and CCC are then expected to be 9.3%, 13.6%, 19.1% and 25.8% the average of 17.0% being a little higher than the EMDP average of 10%. Likewise retake rates with grades of BBB, BBC, BCC and CCC are expected to be 31.7%, 40.0%, 48.8% and 57.7%, with the average of 44.6%, which again is a little higher than the EMDP’s rate of 32%. Were students to be admitted with grades of DDD or EEE then their failure rates would be expected to be 51% and 76%, with retake rates of 81% and 94%.
The calculation of constructlevel predictive validity explicitly makes predictions outside of the normal range of the data for which the correlations were calculated. Although prediction outside of the range is often regarded as bad practice, it is precisely what constructlevel predictive validity sets out to do, with a strong theoretical rationale and model behind it; and as the Statistical Appendix (Additional file 1) shows, the HSL method succeeds well at extrapolating correctly to the true figures in a simulation. The King’s EMDP data provide an independent validation of the predicted marks and failure rates. Failure rates and retake rates at BMS exams, and average marks at finals are predicted well from the estimates of constructlevel predictive validity, being what would be expected given the Alevel grades of the students. That provides confidence in the principle of calculating constructlevel predictive validity as a basis for making selection decisions.
A* grades at Alevel
None of the studies described here had information on A* grades at Alevel, which were first taken by students sitting Alevels in 2010. Few data have been published on A* grades in medical students, although in February 2013 data were published from Oxford, which is one of the most selective of UK medical schools. Of 2,054 applicants with Alevels, there were 16.7% with grades of less than AAA, 19.% with AAA, 22.4% with at least one A*, 16.9% with at least two A*s, and 24.8% with at least three A*s, with the proportions in those holding offers being 0.7%, 5.7%, 14.3%, 19.4% and 60.0% for grades AAA to A*A*A*. Scoring AAA = 30, AAA* = 32, AA*A* = 34 and A*A*A* = 36 [64], and using the estimates of reliability and constructlevel predictive validity used for the King’s study (above), then compared with students scoring AAA, students with AAA*, AA*A* and A*A*A* grades are predicted to score .22, .45 and .67 SDs higher at BMS, and .19, .38 and .56 SDs higher at finals. Those predictions will soon be testable, in all medical schools and not just Oxford, and if correct then the utility of constructlevel predictive validity will also be supported.
Comparison with other studies of selection
This discussion is not the place for a full review of other studies which have assessed educational attainment measures and measures of intellectual aptitude as possible predictors of university and medical school performance. In US medical schools, there seems little doubt that MCAT [65] predicts medical school performance, with the Biological Sciences knowledge test having a higher prediction than the verbal reasoning (aptitude) test. For university admission in general, in the UK both ISPIUA [66, 67] (in the 1960s) and the Sutton Trust SAT test [56, 68] (in the 2000s) showed similar results, with Alevels being strong predictors of university performance and intellectual aptitude tests having little predictive value. The findings reported here are therefore compatible with other largescale studies, albeit mostly not in medicine.
Limitations of the present analysis
The present study is limited to a relatively small number of studies, albeit most include entrants to many UK medical schools, but longitudinal cohort studies are rare. The outcome variables are not always detailed, and postgraduate outcomes are restricted to the criteria of MRCP(UK) marks and Specialist Register entry. The statistical analyses also have to use estimates of some parameters such as reliabilities and selection ratios, and the unreliability of these may not have been taken fully into account. Future studies should examine a wider range of measures of clinical knowledge and performance. The outcomes considered here are almost entirely academic measures of success, and other, nonacademic measures of clinical and professional performance in medical practice, would be desirable.
What is the missing ‘dark variance’ of medical education?
Ultimately 100% of the true variance in medical school performance has to be accounted for, once unreliability, regression to the mean and rightcensorship have been taken into account, even if some of that variance is sporadic (what one might call ‘deep chance’, to distinguish it from mere noise due to measurement error, and containing things such as the random, unpredictable events of every life, referred to earlier). The situation is akin to that currently being experienced in astrophysics, where the existence of ‘dark matter’ and ‘dark energy’ are inferred from the necessity, in what is effectively an accounting exercise, of accounting for the total mass of the universe and the expansion of the universe, all of which needs to be explained. Medical education also cannot account for all of the variation that needs accounting for, and selection of medical students can never be on a firm foundation without it being able to do so. Nevertheless, the present results provide robust support for the use of measures of educational attainment in student selection.
Conclusions
Educational attainment at secondary school strongly predicts both undergraduate and postgraduate performance once attenuation due to unreliability, restriction of range and right censorship of educational qualifications has been taken into account. Alevel grades in particular account for about 65% of true variance in first year performance, which strongly justifies the use of Alevels in student selection. If Alevels do account for 65% of variance, then the remaining 35% of variance must be accounted for by other, nonacademic factors, measurement error, range restriction and rightcensorship having already been taken into account). Just as in astrophysics, ‘dark matter’ and ‘dark energy’ are posited to balance various theoretical equations, so medical student selection must also have its ‘dark variance’, whose nature is not yet properly characterized, but explains perhaps a third of the variation in performance during training. Some variance probably relates to factors which are unpredictable at selection, such as illness or other life events, but some is probably also associated with factors such as personality, motivation or study skills.
Endnote
^{a}This may seem paradoxical at first glance. For the correction formulae of Hunter et al., when reliabilities are one and the selection ratio is one then the constructlevel predictive validity is the same as the simple predictoroutcome correlation. Of necessity, constructlevel predictive validity can only be higher or the same as simple predictoroutcome correlations (just as correlations disattenuated for lack of reliability must be higher than uncorrected correlations). Lower reliabilities and lower selection ratios therefore result in higher constructlevel predictive validities. When reliabilities are low then there is less variance which is truly accounted for (but more that could be accounted for with a better test), and when selection ratios are low then the applicants have a much wider range of scores, both of which push up construct validity. The calculations for the standard Hunter, Schmidt and Le model are shown in Additional file 2, with a variety of situations with different values of the various parameters.
Abbreviations
 aAH5:

Abbreviated AH5
 AH5:

Group test of General Intelligence [devised by Alice Heim]
 Alevel:

Advanced level examinations
 BMAT:

BioMedical Admissions Test
 BMS:

Basic Medical Sciences
 CI:

Confidence interval
 CLPV:

Constructlevel predictive validity
 EM:

ExpectationMinimization
 EMDP:

Extended Medical Degree Programme
 GAMSAT:

Graduate Medical School Admissions Test
 GCE:

General Certificate of Education
 GCSE:

General Certificate of Secondary Education
 GMC:

General Medical Council
 GP:

General practice/general practitioner
 HSL:

Hunter, Schmidt and Le model
 ISPIUA:

Investigation into supplementary predictive information for university admissions
 LRMP:

List of registered medical practitioners
 MCAT:

Medical College Admissions Test
 MCMC:

Markov chain Monte Carlo algorithm
 MRCP(UK):

Membership of the Royal College of Physicians of the United Kingdom
 MSAT:

Medical School Admissions Test
 Olevel:

Ordinary level examinations
 PACES:

Practical assessment of clinical examination skills
 POC:

Predictoroutcome correlation
 SD:

Standard deviation
 SPSS:

Statistical Package for the Social Sciences
 SQA:

Scottish Qualifications Authority
 UCL:

University College London
 UCLMS:

University College London Medical School
 UCMSM:

University College and Middlesex School of Medicine
 UK:

United Kingdom
 UKCAT:

United Kingdom Clinical Aptitude Test
 UMAT:

Undergraduate Medicine and Health Sciences Admission Test
 UMDS:

United Medical and Dental Schools (Guy’s and St. Thomas’s).
Declarations
Acknowledgments
We are grateful to all those who have worked on and contributed to the various cohort studies, and particularly for those working on the UKCAT project, including Rachel Greatrix, David Ridley and John Kernthaler. The data on UKCAT are presented on behalf of the UKCAT Board and with their collaboration.
The 1990, 1985 and 1980 Cohort Studies have been funded by a variety of organizations, including the Economic and Social Research Council, the Leverhulme Trust, the Nuffield Foundation, the Department of Health, North Thames Medical and Dental Education and the London Deanery. The analysis of the UKCAT12 data was supported by a small amount of funding to the institutions which employ ICM and CD.
Authors’ Affiliations
References
 McManus IC, Powis DA, Wakeford R, Ferguson E, James D, Richards P: Intellectual aptitude tests and A levels for selecting UK school leaver entrants for medical school. BMJ. 2005, 331: 555559. 10.1136/bmj.331.7516.555.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Ferguson E, Wakeford R, Powis D, James D: Predictive validity of the BioMedical Admissions Test (BMAT): an evaluation and case study. Med Teach. 2011, 33: 5357. 10.3109/0142159X.2010.525267.View ArticlePubMedGoogle Scholar
 McManus IC, Smithers E, Partridge P, Keeling A, Fleming PR: A levels and intelligence as predictors of medical careers in UK doctors: 20 year prospective study. BMJ. 2003, 327: 139142. 10.1136/bmj.327.7407.139.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Woolf K, Dacre J, Paice E, Dewberry C: The Academic Backbone: Longitudinal Continuities in Educational Achievement from Secondary School and Medical School to MRCP(UK) and the Specialist Register in UK Medical Students and Doctors. BMC Med. 2013, 11: 242.View ArticlePubMedPubMed CentralGoogle Scholar
 Ghiselli EE, Campbell JP, Zedeck S: Measurement Theory for the Behavioral Sciences. 1981, San Francisco: W H FreemanGoogle Scholar
 Streiner DL, Norman GR: Health Measurement Scales: a Practical Guide to their Development and Use. 2008, Oxford, UK: Oxford University Press, 4View ArticleGoogle Scholar
 The Concept of Validity: Revisions, New Directions, and Applications. Edited by: Lissitz RW. 2009, Charlotte, NC: Information Age PublishingGoogle Scholar
 Hunter JE, Schmidt FL, Le H: Implications of direct and indirect range restriction for metaanalysis methods and findings. J Appl Psychol. 2006, 91: 594612.View ArticlePubMedGoogle Scholar
 Bagg DG: Alevels and university performance. Nature. 1970, 225: 11051108. 10.1038/2251105a0.View ArticlePubMedGoogle Scholar
 General Medical Council: Conference on Methods of Examination and Assessment, February 28, 1973. 1973, London: General Medical CouncilGoogle Scholar
 Burt C: Validating tests for personnel selection. BJP. 1943, 34: 119.Google Scholar
 Pearson K: Mathematical contributions to the theory of evolution. XI: On the influence of natural selection on the variability and correlation of organs. Phil Trans R Soc Lond A. 1903, 200: 166. 10.1098/rsta.1903.0001.View ArticleGoogle Scholar
 Lawley D: A note on Karl Pearson's selection formulae. Proc R Soc Edinburgh: Sec A. 1944, 62: 2830.Google Scholar
 Rydberg S: Bias in Prediction: on Correction Methods. 1963, Stockholm: Almqvist & WiksellGoogle Scholar
 Lord FM, Novick MR: Statistical theories of Mental Test Scores. 1968, Reading, MA, USA: AddisonWesleyGoogle Scholar
 Schmidt FL, Ones DS, Hunter JE: Personnelselection. Annu Rev Psychol. 1992, 43: 627670. 10.1146/annurev.ps.43.020192.003211.View ArticleGoogle Scholar
 Callahan CA, Hojat M, Veloksi J, Erdmann JB, Gonnella JS: The predictive validity of three versions of the MCAT in relation to performance in medical school, residency, and licensing examinations: a longitudinal study of 36 classes of Jefferson Medical College. Acad Med. 2010, 85: 980987. 10.1097/ACM.0b013e3181cece3d.View ArticlePubMedGoogle Scholar
 Admissions to Higher Education Steering Group: Fair Admissions to Higher Education: Recommendations for Good Practice. 2004, Nottingham, UK: Department for Education and Skills Publications, [http://www.admissionsreview.org.uk]Google Scholar
 Heim AW: AH5 Group Test of HighGrade Intelligence. 1968, Windsor: NFERNelsonGoogle Scholar
 UKCAT: UKCAT: 2006 Annual Report. 2008, Nottingham: United Kingdom Clinical Aptitude Test, available at [http://www.ukcat.ac.uk/App_Media/uploads/pdf/Annual%20Report%202006.pdf]Google Scholar
 McManus IC, Dewberry C, Nicholson S, Dowell J: The UKCAT12 Study: Educational Attainment, Aptitude Test Performance, Demographic and SocioEconomic Contextual Factors as Predictors of First Year Outcome in a Collaborative Study of Twelve UK Medical Schools. BMC Med. 2013, 11: 244.View ArticlePubMedPubMed CentralGoogle Scholar
 Thompson SG, Higgins JPT: How should metaregression analyses be undertaken and interpreted?. Stat Med. 2002, 21: 15591573. 10.1002/sim.1187.View ArticlePubMedGoogle Scholar
 McManus IC, Richards P: An audit of admission to medical school: 1  Acceptances and rejects. Br Med J (Clin Res Ed). 1984, 289: 12011204. 10.1136/bmj.289.6453.1201.View ArticleGoogle Scholar
 McManus IC, Richards P, Maitlis SL: Prospective study of the disadvantage of people from ethnic minority groups applying to medical schools in the United Kingdom. BMJ. 1989, 298: 723726. 10.1136/bmj.298.6675.723.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Richards P, Winder BC, Sproston KA, Styles V: Medical school applicants from ethnic minorities: identifying if and when they are disadvantaged. BMJ. 1995, 310: 496500. 10.1136/bmj.310.6978.496.View ArticlePubMedPubMed CentralGoogle Scholar
 Woolf K, McManus IC, Potts HW, Dacre JE: The mediators of minority ethnic underperformance in final medical school examinations. Br J Educ Psychol. 2013, 83: 135159. 10.1111/j.20448279.2011.02060.x.View ArticlePubMedGoogle Scholar
 McManus IC, Dewberry C, Nicholson S, Dowell J: The UKCAT12 Study: Technical Report. 2012, Nottingham: UKCAT Consortium, available at [http://www.ukcat.ac.uk/App_Media/uploads/pdf/UKCATTechnicalReportMarch2012WithBackgroundAndSummarySep2013v2.pdf]Google Scholar
 McManus IC, Elder AT, De Champlain A, Dacre JE, Mollon J, Chis L: Graduates of different UK medical schools show substantial differences in performance on MRCP(UK) Part 1, Part 2 and PACES examinations. BMC Med. 2008, 6: 510.1186/1741701565.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Ludka K: Resitting a highstakes postgraduate medical examination on multiple occasions: nonlinear multilevel modelling of performance in the MRCP(UK) examinations. BMC Med. 2012, 10: 6010.1186/174170151060.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Richards P, Winder BC, Sproston KA: Clinical experience, performance in final examinations, and learning style in medical students: prospective study. BMJ. 1998, 316: 345350. 10.1136/bmj.316.7128.345.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Richards P, Winder BC: Intercalated degrees, learning styles, and career preferences: prospective longitudinal study of UK medical students. BMJ. 1999, 319: 542546. 10.1136/bmj.319.7209.542.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Winder BC, Paice E: How consultants, hospitals, trusts and deaneries affect preregistration house officer posts: a multilevel model. Med Educ. 2002, 36: 3544. 10.1046/j.13652923.2002.01123.x.View ArticlePubMedGoogle Scholar
 Paice E, Rutter H, Wetherell M, Winder BC, McManus IC: Stressful incidents, stress and coping strategies in the preregistration house officer year. Med Educ. 2002, 36: 5665. 10.1046/j.13652923.2002.01101.x.View ArticlePubMedGoogle Scholar
 McManus IC, Keeling A, Paice E: Stress, burnout and doctors' attitudes to work are determined by personality and learning style: a twelve year longitudinal study of UK medical graduates. BMC Med. 2004, 2: 2910.1186/17417015229.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Jonvik H, Richards P, Paice E: Vocation and avocation: leisure activities correlate with professional engagement, but not burnout, in a crosssectional study of UK doctors. BMC Med. 2011, 9: 10010.1186/174170159100.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Richards P, Winder BC, Sproston KA: Final examination performance of students from ethnic minorities. Med Educ. 1996, 30: 195200. 10.1111/j.13652923.1996.tb00742.x.View ArticlePubMedGoogle Scholar
 McManus IC, Richards P: An audit of admission to medical school: 2  Shortlisting and interviews. Br Med J (Clin Res Ed). 1984, 289: 12881290. 10.1136/bmj.289.6454.1288.View ArticleGoogle Scholar
 McManus IC, Richards P: An audit of admission to medical school: 3  Applicants' perceptions and proposals for change. Br Med J (Clin Res Ed). 1984, 289: 13651367. 10.1136/bmj.289.6455.1365.View ArticleGoogle Scholar
 McManus IC, Richards P: Prospective survey of performance of medical students during preclinical years. Br Med J (Clin Res Ed). 1986, 293: 124127. 10.1136/bmj.293.6539.124.View ArticleGoogle Scholar
 Haario H, Laine M, Mira A, Saksman E: DRAM: Efficient adaptive MCMC. Statistics and Computing. 2006, 16: 339354. 10.1007/s1122200694380.View ArticleGoogle Scholar
 Field AP, Gillett R: How to do a metaanalysis. Brit J Math Stat Psychol. 2010, 63: 665694. 10.1348/000711010X502733.View ArticleGoogle Scholar
 Bramley T, Dhawan V: Estimates of reliability of qualifications. 2011, Coventry: Office of Qualifications and Examinations Regulation, [http://www.ofqual.gov.uk/files/reliability/110316EstimatesofReliabilityofqualifications.pdf]Google Scholar
 UKCAT: UKCAT: 2007 Annual Report. 2008, Nottingham: United Kingdom Clinical Aptitude Test, available at [http://www.ukcat.ac.uk/App_Media/uploads/pdf/Annual%20Report%202007.pdf]Google Scholar
 UKCAT: UKCAT 2008 Annual Report. 2008, Nottingham, UK: UKCAT, available at http://www.ukcat.ac.uk/App_Media/uploads/pdf/Annual%20Report%202008.pdf.Google Scholar
 Bacon DR, Bean B: GPA in research studies: an invaluable but neglected opportunity. J Marketing Educ. 2006, 28: 3542. 10.1177/0273475305284638.View ArticleGoogle Scholar
 McManus IC, MooneySomers J, Dacre JE, Vale JA: Reliability of the MRCP(UK) Part I Examination, 1984–2001. Med Educ. 2003, 37: 609611. 10.1046/j.13652923.2003.01568.x.View ArticlePubMedGoogle Scholar
 Tighe J, McManus IC, Dewhurst NG, Chis L, Mucklow J: The standard error of measurement is a more appropriate measure of quality in postgraduate medical assessments than is reliability: An analysis of MRCP(UK) written examinations. BMC Med Educ. 2010, 10: 4010.1186/147269201040.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Thompson M, Mollon J: Assessment of examiner leniency and stringency ('hawkdove effect') in the MRCP(UK) clinical examination (PACES) using multifacet Rasch modelling. BMC Med Educ. 2006, 6: 410.1186/1472692064.View ArticleGoogle Scholar
 Yates J, James D: Predicting the ”strugglers”: a case–control study of students at Nottingham University Medical School. BMJ. 2006, 332: 10091013. 10.1136/bmj.38730.678310.63.View ArticlePubMedPubMed CentralGoogle Scholar
 Yates J, James D: Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case–control study. BMJ. 2010, 340: c204010.1136/bmj.c2040.View ArticlePubMedPubMed CentralGoogle Scholar
 Yates J: Development of a 'toolkit' to identify medical students at risk of failure to thrive on the course: an exploratory retrospective case study. BMC Med Educ. 2011, 11: 9510.1186/147269201195.View ArticlePubMedPubMed CentralGoogle Scholar
 Hunter JE, Schmidt FL: Methods of MetaAnalysis: Correcting Error and Bias in Research Findings. 2004, Thousand Oaks, CA: Sage, 2View ArticleGoogle Scholar
 Rubin DB: A new perspective on metaanalysis. The Future of MetaAnalysis. Edited by: Wachter KW, Straf ML. 1990, New York: Russell Sage, 155166.Google Scholar
 McManus IC, Woolf K, Dacre J: The educational background and qualifications of UK medical students from ethnic minorities. BMC Med Educ. 2008, 8: 2110.1186/14726920821.View ArticlePubMedPubMed CentralGoogle Scholar
 Coe R, Searle J, Barmby P, Jones K, Higgins S: Relative difficulty of examinations in different subjects. 2008, Durham, UK: CEMCENTRE, http://www.cem.org/attachments/SCORE2008report.pdf.Google Scholar
 Kirkup C, Wheater R, Morrison J, Durbin B, Pomati M: Use of an aptitude test in university entrance: A validity Study. Final report. 2010, National Foundation for Educational Research: Slough, UKGoogle Scholar
 Garlick PB, Brown G: Widening participation in medicine. BMJ. 2008, 336: 11111113. 10.1136/bmj.39508.606157.BE.View ArticlePubMedPubMed CentralGoogle Scholar
 Brown G, Garlick P: Changing geographies of access to medical education in London. Health Place. 2007, 13: 520531. 10.1016/j.healthplace.2006.07.001.View ArticlePubMedGoogle Scholar
 Brown G: The Place of Aspirations: Thoughts from a Research Project. [http://placeofaspirations.wordpress.com/2011/07/08/attainingprivilegethegeographyofadmissionstoeliteuniversities/]
 Ip H, McManus IC: Increasing diversity among clinicians. BMJ. 2008, 336: 10821083. 10.1136/bmj.39569.609641.80.View ArticlePubMedPubMed CentralGoogle Scholar
 Garlick P: Can Students with BCC Rather than AAA at A Level Succeed at Medical School? The Evidence from King's College London. 2012, London: King's College London, [http://www.slideserve.com/omer/canstudentswithbccratherthanaaaatalevelsucceedatmedicalschooltheevidencefromkingscollegelondon]Google Scholar
 Bekhradnia B, Thompson J: Who does Best at University?. 2002, London: Higher Education Funding Council England, [http://webarchive.nationalarchives.gov.uk/20081202000732/http://hefce.ac.uk/Learning/whodoes/]Google Scholar
 Mahesan N, Crichton S, Sewell H, Howell S: The effect of an intercalated BSc on subsequent academic performance. BMC Med Educ. 2011, 11: 7610.1186/147269201176.View ArticlePubMedPubMed CentralGoogle Scholar
 McManus IC, Woolf K, Dacre JE: Even one star at A level could be "too little, too late" for medical student selection. BMC Med Educ. 2008, 8: 1610.1186/14726920816.View ArticlePubMedPubMed CentralGoogle Scholar
 Donnon T, Paolucci EO, Violato C: The predictive validity of the MCAT for medical school performance medical board licensing examinations: a metaanalysis of the published research. Acad Med. 2007, 82: 100106. 10.1097/01.ACM.0000249878.25186.b7.View ArticlePubMedGoogle Scholar
 Choppin BHL, Orr L, Fara P, Kurie SDM, Fogelman KR, James G: After ALevel? A Study of the Transition from School to Higher Education. 1972, Slough: NFER Publishing Company Ltd.Google Scholar
 Choppin B, Orr L: Aptitude Testing at EighteenPlus. 1976, Windsor: NFER Publishing Company Ltd.Google Scholar
 Kirkup C, Schagen I, Wheater R, Morrison J, Whetton C: Use of an Aptitude Test in University Entrance  A Validity Study: Relationships between SAT Scores, Attainment Measures and Background Variables. 2007, London: Department for Education and Skills, Research Report RR846Google Scholar
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