Renal involvement in autoimmune connective tissue diseases
© Kronbichler and Mayer; licensee BioMed Central Ltd. 2013
Received: 15 November 2012
Accepted: 11 February 2013
Published: 4 April 2013
Connective tissue diseases (CTDs) are a heterogeneous group of disorders that share certain clinical presentations and a disturbed immunoregulation, leading to autoantibody production. Subclinical or overt renal manifestations are frequently observed and complicate the clinical course of CTDs. Alterations of kidney function in Sjögren syndrome, systemic scleroderma (SSc), auto-immune myopathies (dermatomyositis and polymyositis), systemic lupus erythematosus (SLE), antiphospholipid syndrome nephropathy (APSN) as well as rheumatoid arthritis (RA) are frequently present and physicians should be aware of that.
In SLE, renal prognosis significantly improved based on specific classification and treatment strategies adjusted to kidney biopsy findings. Patients with scleroderma renal crisis (SRC), which is usually characterized by severe hypertension, progressive decline of renal function and thrombotic microangiopathy, show a significant benefit of early angiotensin-converting-enzyme (ACE) inhibitor use in particular and strict blood pressure control in general. Treatment of the underlying autoimmune disorder or discontinuation of specific therapeutic agents improves kidney function in most patients with Sjögren syndrome, auto-immune myopathies, APSN and RA.
In this review we focus on impairment of renal function in relation to underlying disease or adverse drug effects and implications on treatment decisions.
KeywordsRenal involvement Connective tissue diseases Sjögren syndrome Scleroderma renal crisis, Dermatomyositis/polymyositis Systemic lupus erythematosus Antiphospholipid syndrome Rheumatoid arthritis
Impairment of renal function is present to some extent in many connective tissue diseases (CTDs) with variable occurrence in Sjögren syndrome [1, 2], roughly 5% in systemic scleroderma (SSc) , rarely in inflammatory auto-immune myopathies, a prevalence of approximately 50% in systemic lupus erythematosus (SLE) , and rare occurrence in antiphospholipid syndrome  and rheumatoid arthritis (RA). Apart from that, kidney involvement can be of significant prognostic value and often entails specific therapeutic implications.
Lymphocytic infiltration, leading to acute or chronic tubulointerstitial nephritis, is the predominant renal pathology in Sjögren syndrome [2, 6, 7]. Scleroderma renal crisis (SRC) is a severe, potentially life-threatening complication in scleroderma and is, in most cases, accompanied by malignant hypertension, overexpression of pro-inflammatory cytokines and rapid decline of renal function [8–10]. In rare cases patients present with normotensive SRC, which is associated with a poorer prognosis and a prompter need for dialysis [11–13]. Early commencement of angiotensin-converting-enzyme (ACE)-inhibitors and other antihypertensive drugs is mandatory in the management of SRC. Rhabdomyolysis with acute tubular necrosis or glomerular disorders, including minimal change disease, membranous nephropathy, IgA nephropathy or diffuse proliferative glomerulonephritis, has been reported in patients with auto-immune myopathies [14, 15].
Overview of kidney biopsy findings in patients with connective tissue diseases
Renal biopsy findings
Connective tissue disease
Tubulointerstitial nephritis (TIN)
Mesangial proliferative glomerulonephritis/IgA nephropathy
Focal segmental glomerulosclerosis (FSGS)
Cryoglobulinemic membrano-proliferative glomerulonephritis
Minimal change disease
Secondary renal amyloidosis
Diffuse proliferative glomerulonephritis
Systemic lupus erythematosus 
Systemic lupus erythematosus 
Necrotizing crescentic glomerulonephritis (including drug-induced forms)
Focal proliferative glomerulonephritis
Rheumatoid arthritis 
Crescentic GN with FSGS
Antiphospholipid syndrome 
Primary Sjögren syndrome (PSS) is an autoimmune disorder of hitherto unknown origin which is characterized by polyclonal B-cell activation as well as lymphocytic infiltration of the exocrine glands, resulting in keratoconjunctivitis sicca (dry eyes disease) and/or xerostomia (dry mouth disease) . In addition, extraglandular manifestations of PSS can affect organ systems, such as the lungs, blood vessels, skin, the gastrointestinal tract, central and peripheral nervous system, muscular skeletal apparatus and the kidney [19, 20]. Affected patients are at increased risk of developing non-Hodgkin’s lymphoma, in particular lymphomas of B-cell origin . Secondary Sjögren syndrome is associated with other rheumatic disorders, such as RA, SLE, SSc and others. Renal disease with PSS is reported to occur in 4.2%  to 67%  of patients. The variation is considered to be associated with the different diagnostic criteria used, different study designs and small cohorts examined as well as selection bias.
Acute or chronic tubulointerstitial nephritis (TIN) with defects in tubular function is the predominant lesion in biopsy-proven renal involvement [2, 6]. Distal (type I) renal tubular acidosis (RTA) is the most common clinical finding, leading to mild symptoms but also to potentially life-threatening complications, such as hypokalemic paralysis . Albeit considered to be rare, proximal (type II) RTA has been reported in some cases [6, 23]. Moreover, glomerular disease, such as cryoglobulinemic membrano-proliferative glomerulonephritis, focal segmental glomerulosclerosis (FSGS), mesangial proliferative glomerulonephritis, membranous nephropathy and minimal change disease have been reported [2, 6, 7, 24]. A single case of long-lasting TIN in a patient with PSS led to a secondary (AA) amyloidosis with, consequently, renal failure and nephrotic syndrome . Interestingly, in one study SSA/Ro, SSB/La and rheumatoid factor, as well as hypergammaglobulinemia, were detected in all subjects with biopsy-proven renal involvement . In another cohort, all patients with distal RTA had positive anti-nuclear antibodies and either SSA or SSB antibodies were detected in 85.7% of them .
Treatment with glucocorticoids should be initiated as first line therapy in patients with PSS and renal involvement since a good response to early treatment has been reported [6, 26]. In addition, long-term bicarbonate and/or electrolyte supplementation should be commenced in a majority of patients to prevent life-threatening complications . Besides corticosteroids, alternative immunosuppressive therapies (hydroxychloroquine, rituximab, cyclophosphamide) should be prescribed based on kidney biopsy findings as well as comorbidities. It was shown that renal function maintained or improved during a median follow-up period of 38 months after treatment with immunosuppressive drugs .
Corticosteroids are a mainstay in the treatment of TIN. Further histologic findings require specifically-tailored immunosuppression and most importantly, supplementation of bicarbonate and/or electrolytes, when indicated, should be commenced.
Scleroderma renal crisis
SSc is a CTD characterized by deposition and overproduction of extracellular matrix proteins and collagen, resulting in tissue fibrosis and, subsequently, tissue dysfunction. Affected organs and tissues include the skin, gastrointestinal tract, heart, lungs and kidneys. Involvement of the vascular system generally results in the development of Raynaud’s phenomenon early in the disease course. Consecutively, severe clinical manifestations of vascular dysfunction can be observed in some patients leading to pulmonary fibrosis and pulmonary artery hypertension, esophageal motility dysfunction, watermelon stomach, cardiac involvement, as well as scleroderma renal crisis (SRC) [27–29]. Epithelial to mesenchymal transition (EMT), a condition that conveys a phenotypic conversion from differentiated epithelial cells to matrix-producing fibroblasts and myofibroblasts, is recognized as a crucial part of the development of tissue fibrogenesis [30, 31]. Several growth factors, such as transforming growth factor ß (TGFß) , connective tissue growth factor (CTGF) , as well as other mediators, such as endothelin-1 , are involved in tissue remodelling. SRC occurs in roughly 5% of patients with SSc . Several risk factors with a predictive value were established: duration of SSc onset of less than four years, higher incidence of progressive skin thickening prior to renal involvement, new development of anemia and cardiac involvement (pericardial effusion or congestive heart failure) . Detection of anti-RNA polymerase III antibodies displays a strong risk marker for the presence of SRC, whereas the presence of anti-topoisomerase and anti-centromere antibodies in scleroderma indicates a favorable disease course . In addition, a case control study revealed a significant positive association between long-lasting high-dose corticosteroid treatment (≥15 g/d) and the onset of SRC . On average, in 10% of patients, SRC occurs in the absence of hypertension. Normotensive renal crisis was more frequently present in patients treated with high doses of corticosteroids and in patients with redundant microangiopathic hemolytic anemia and thrombocytopenia in consequence to the underlying disease . In addition, normotensive renal failure in SSc was associated with a higher mortality rate and an earlier need for dialysis treatment [11–13]. Blood pressure levels greater than 150/90 mmHg were observed in almost 90% of patients experiencing SRC. Hypertensive SRC is accompanied by clinical signs of malignant hypertension with left ventricular failure, hypertensive encephalopathy and arrhythmia .
Diagnosis of SRC is confirmed by renal biopsy, which shows a thrombotic microangiopathic process, particularly affecting small vessels. Vascular changes are accompanied by thrombosis, accumulation of myxoid material and later in the disease course, development of onion-skin lesions and/or fibrointimal sclerosis . Furthermore, one has to keep in mind that ANCA-associated vasculitis is a rare complication of SSc and in general presents with antibodies directed against myeloperoxidase and p-ANCA .
Early use of ACE inhibitors, on the basis of most experience in particular captopril, is undoubtedly a cornerstone in the management of hypertensive SRC. Immediate use with a progressive increase of ACE inhibitor dosage, even in the presence of deteriorating kidney function, is considered to prevent or even reverse renal failure [36, 37]. Additional antihypertensive therapy (calcium channel blockers, alpha/beta-adrenoreceptor antagonists and/or minoxidil) is mandatory when blood pressure is insufficiently controlled [28, 36]. Recent findings suggest that dialysis was required in more than 50% of patients either in case of volume overload together with renal deterioration or to control blood pressure due to therapy-resistant hypertension [3, 12]. Discontinuation of dialysis treatment could be accomplished in 16 to 55% patients with SRC [3, 37]. After a stable disease course with continuous dialysis, renal transplantation should be considered when contraindications are ruled out. In a cohort of 260 patients with SSc who underwent kidney transplantation, the overall five-year graft survival rate was 56.7%. Among those, the recurrence of disease after transplantation was 6.7% in a report of the United Network of Organ Sharing (UNOS) . Based on the finding that cyclosporine A (CSA) may be responsible for acute renal failure in patients with SSc , calcineurin inhibitors are not generally recommended as immunosuppressants after kidney transplantation.
Renal involvement in SSc is often accompanied by progressive renal failure and rapid initiation of therapeutic interventions is mandatory. Blood pressure control, in particular with ACE-inhibitors and additional antihypertensive medication, is essential. If blood pressure is not adjustable or the patient shows signs of fluid overload, dialysis should be considered early in the disease course. Discontinuation of dialysis was reported in some patients. In patients with chronic hemodialysis and renal transplantation, a calcineurin-inhibitor free immunosuppressive regimen might be chosen.
Dermatomyositis and polymyositis
Auto-immune myopathies, namely dermatomyositis (DM) and polymyositis (PM), share common clinical features, such as proximal muscle weakness, muscle inflammation, presence of autoantibodies, elevated muscle enzymes, electromyographic alterations and extra muscular manifestations. Despite clinical similarities, both differ regarding muscle biopsy findings and DM is associated with cutaneous involvement. The presence of a heliotrope rash, which is characterized by a violaceous skin discoloration around the eyes, and Gottron’s sign (erythematous papules with involvement of joints) are pathognomonic for DM [40, 41]. Both entities are associated with concurrent incidence of neoplasms. In large cohorts, malignancies were detected in 9.4 to 32% of patients in DM and in 4.4 to 17% in PM patients [42–45] with a predominance of adenocarcinomas .
Two types of renal involvement have been described in patients with PM/DM. First, rhabdomyolysis with release of myoglobin can lead to acute tubular necrosis with deterioration of renal function [14, 15]. Second, several reports revealed the occurrence of chronic glomerulonephritis in patients with PM/DM [14, 46–49]. In PM, mesangial proliferative glomerulonephritis represents the leading glomerular lesion [46, 50, 51]. Moreover, other biopsy specimens showed lipoid nephrosis with FSGS , membranous nephropathy  and crescentic glomerulonephritis with FSGS . In contrast, the predominant finding in DM with renal involvement is membranous nephropathy [55–57]. Nevertheless, both mesangial proliferative glomerulonephritis  and diffuse proliferative glomerulonephritis  have been reported in single case reports.
High-dose oral corticosteroids are the cornerstone of DM/PM therapy. Moreover, the addition of immunosuppressive drugs, such as azathioprine (AZA) or cyclophosphamide (CYC), as well as anti-malaria medication in DM and methotrexate, CYC, intravenous immunoglobulins and CSA in PM has been reported to improve the renal outcome in DM/PM [14, 49, 55–58]. In contrast to these reports, one patient progressed to end-stage renal disease despite immunosuppressive treatment . Follow-up of the patients with DM revealed a high mortality rate due to cancer or multi-organ failure, while mortality in PM was high due to acute rhabdomyolysis followed by severe hyperkalemia and metabolic acidosis in a case report .
Management of patients with auto-immune myopathies and renal involvement require special caution, because disease-related mortality due to rhabdomyolysis and hyperkalemia is greatly feared. Special therapeutic intervention with immunosuppression should be tailored to the underlying histology. In most cases, corticosteroids might be effective as one therapeutic component.
Systemic lupus erythematosus
Revised criteria of the American College of Rheumatology
1. Malar rash
Fixed erythema, flat or raised, over the malar eminences, tending to spare the nasolabial folds
2. Discoid rash
Erythematous raised patches with adherent keratotic scaling and follicular plugging; atrophic scarring may occur in older lesions
Skin rash as a result of unusual reaction to sunlight, by patient history or physician observation
4. Oral ulcers
Oral or nasopharyngeal ulceration, usually painless, observed by physician
5. Non-erosive arthritis
Involving two or more peripheral joints, characterized by tenderness, swelling or effusion
1. Pleuritis, convincing history of pleuritic pain or rubbing heard by a physician or evidence of pleural effusion, or
2. Pericarditis, documented by electrocardiogram or rub or evidence of pericardial effusion
7. Renal disorder
1. Persistent proteinuria >0.5 grams per day or more than 3+ on urine dipstick testing, or
2. Cellular casts (may be red cell, hemoglobin, granular, tubular, or mixed)
8. Neurologic disorder
1. Seizures, in the absence of offending drugs or known metabolic derangements; for example, uremia, ketoacidosis, or electrolye imbalance, or
2. Psychosis, in the absence of offending drugs or known metabolic derangements; for example, uremia, ketoacidosis, or electrolyte imbalance
9. Hematologic disorder
1. Hemolytic anemia with reticulocytosis, or
2. Leukopenia <4.000/mm3 on ≥2 occasions, or
3. Lymphopenia <1.500/mm3 on ≥2 occasions, or
4. Thrombocytopenia <100.000/mm3 in the absence of offending drugs
10. Immunologic disorder
1. Anti-DNA: antibody to native DNA in abnormal titer, or
2. Anti-Sm: presence to antibody of SM nuclear antigen, or
3. Positive finding of antiphospholipid antibodies on:
● An abnormal serum level of IgG or IgM anticardiolipin antibodies
● A positive test result for lupus anticoagulant using a standard method, or
● A false-positive test result for at least six months confirmed by Treponema pallidum immobilization or fluorescent treponemal antibody absorption test
11. Positive anti-nuclear antibody
An abnormal titer of anti- nuclear antibody by immunofluorescence or an equivalent assay at any point in time and in the absence of drugs
Autoantibodies are directed against various nuclear antigens, in particular against chromatin components, such as nucleosomes, histones, anti-nuclear antibodies (ANA), double-stranded DNA antibodies (dsDNA) and ribonucleoproteins. Recently, it was suggested that the nucleosome might be the driving autoantigen in SLE. This hypothesis is supported by the finding that glomerular deposition of anti-dsDNA antibodies in lupus nephritis is mediated by nucleosomes [66, 67]. The kidneys are a major source of autoantibody-producing plasma cells in lupus nephritis and these differentiated plasma cells are frequently observed in patients with severe renal involvement (mainly classes III through V), potentially acting in amplifying the renal disease course . Additional autoantibodies include anti-Smith (Sm) antibodies with a high specificity for SLE, while SSA and SSB are present in other CTDs as well . Complement levels are frequently reduced in patients with active disease. Genetic complete complement deficiencies can resemble a SLE-like disease . Levels of complement C3 and C4 correlate with the overall disease activity. Patients with active lupus nephritis had significantly lower levels of C3 and C4 compared to patients with inactive lupus nephritis . Serum C3 has generally higher sensitivity than serum C4, but both tests have only modest specificity for active lupus nephritis . Assessment of the relationship between serum levels of C3 or C4 and renal flares revealed that C4 is critical for initiating a renal flare, while C3 activation is involved in the actual tissue damage . Antibodies directed against C1q were detected in all patients with active nephritis in a large cohort . Moreover, anti-C1q antibodies showed the strongest association with proteinuria among potential biomarkers and were significantly correlated with Renal Activity Score . However, contradictory to these reports, in a cohort of 126 patients, anti-C1q antibodies were not significantly associated with active lupus nephritis .
Revised classification lupus nephritis according to the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003
Minimal mesangial lupus nephritis
Normal glomeruli by light microscopy, but mesangial immune deposits by immunofluorescence
Mesangial proliferative lupus nephritis
Purely mesangial hypercellularity of any degree or mesangial matrix expansion by light microscopy, with mesangial immune deposits
May be a few isolated subepithelial deposits visible by immunofluorescence or electron microscopy, but not by light microscopy
Focal lupus nephritis
Active or inactive focal, segmental or global endo- or extracapillary glomerulonephritis involving <50% of all glomeruli, typically with focal subendothelial immune deposits, with or without mesangial alterations
Class III (A)
Active lesions: focal proliferative lupus nephritis
Class III (A/C)
Active and chronic lesions: focal proliferative and sclerosing lupus nephritis
Class III (C)
Chronic inactive lesions with glomerular scars: focal sclerosing lupus nephritis
Diffuse lupus nephritis
Active or inactive diffuse, segmental or global endo- or extracapillary glomerulonephritis involving ≥50% of all glomeruli, typically with diffuse subendothelial immune deposits, with or without mesangial alterations. This class is divided into diffuse segmental (IV-S) lupus nephritis when ≥50% of the involved glomeruli have segmental lesions, and diffuse global (IV-G) lupus nephritis when ≥50% of the involved glomeruli have global lesions. Segmental is defined as a glomerular lesion that involves less than half of the glomerular tuft. This class includes cases with diffuse wire loop deposits but with little or no glomerular proliferation
Class IV-S (A)
Active lesions: diffuse segmental proliferative lupus nephritis
Class IV-G (A)
Active lesions: diffuse global proliferative lupus nephritis
Class IV-S (A/C)
Active and chronic lesions: diffuse segmental proliferative and sclerosing lupus nephritis
Active and chronic lesions: diffuse global proliferative and sclerosing lupus nephritis
Class IV-S (C)
Chronic active lesions with scars: diffuse segmental sclerosing lupus nephritis
Class IV-G (C)
Chronic inactive lesions with scars: diffuse global sclerosing lupus nephritis
Membranous lupus nephritis
Global or segmental subepithelial immune deposits or their morphologic sequelae by light microscopy and by immunofluorescence or electron microscopy, with our without mesangial alterations
Class V lupus nephritis may occur in combination with class III or IV in which case both will be diagnosed
Class V lupus nephritis show advanced sclerosis
Advanced sclerosis lupus nephritis
≥90% of glomeruli globally sclerosed without residual activity
In general, use of ACE inhibitors significantly reduced the development of proteinuria and/or biopsy-proven lupus nephritis and was associated with a decreased risk of disease activity . Concomitant use of antimalarial drugs (chloroquine and hydroxychloroquine) at diagnosis of lupus nephritis reduced the risk of progression to end-stage renal failure and frequency of hypertension .
Specific treatment follows the class of lupus nephritis, which is defined by the revised ISN criteria. Class I and class II require no therapy directed at the kidney in consequence of good long-term renal outcome . In contrast, high-dose steroid therapy rapidly resolved nephrotic syndrome in a majority of SLE patients with minimal change disease either in the absence or with underlying class II lupus nephritis based on renal biopsy findings [82, 83]. Immunosuppressive treatment is required in the management of class III (focal), class IV (diffuse) and class V (membranous nephropathy) lupus nephritis and usually consists of high dose glucocorticoid therapy along with intravenous CYC or mycophenolate mofetil (MMF) as induction therapy. The Euro Lupus Nephritis Trial compared low dose CYC (fortnightly, at a fixed dose of 500 mg, with a cumulative dose of 3 g) with the previously established high dose CYC (NIH) regimen (mean cumulative dose 8.5 g). Both strata were followed by AZA as remission-maintaining treatment. Renal outcome was similar in both treatment arms, but the low dose CYC group had fewer severe infections, even though the difference was not statistically significant . Reports from this trial with a 10-year duration of follow-up confirmed the efficacy of the Euro Lupus regimen . Since a majority of the subjects were white in this trial, these results might be less applicable to other ethnicities. In a more diversified cohort (>50% blacks) MMF (mean daily dosage 2.68 g) has been reported to be superior as induction therapy when compared to monthly CYC (0.5 g to 1 g/m2) in patients with class III through V lupus nephritis . A further large, multi-center trial in a balanced cohort with respect to ethnicities designed to show superiority of MMF (mean daily dosage 2.47 g) to CYC failed to meet the primary end point. Both treatment arms achieved virtually identical rates of complete and partial remission. Furthermore, no significant difference with regard to severe adverse events or infections was reported . Response to MMF as induction treatment in pure class V (membranous nephropathy) lupus nephritis in patients with diverse racial background appeared to show no difference in comparison to CYC . Patients (>60% black) with class V lupus nephritis showed a better response regarding induction of remission after CSA when compared to CYC, whereas relapse of nephrotic syndrome occurred more frequently in patients with prior CSA therapy . In a small cohort, multi-target therapy (MMF and tacrolimus) in patients with class IV and class V lupus nephritis revealed a higher rate of complete remission with a good tolerability when compared to intravenous CYC .
Following induction therapy, long-term immunosuppression is mandatory to avoid severe flares and to maintain stabilization of disease activity. Thus, immunosuppressants with a favorable safety profile and good efficacy are mandatory. MMF and AZA are deemed suitable and have shown efficacy in maintaining remission of lupus nephritis . Equivalence of MMF and AZA was reported in the MAINTAIN Nephritis Trial, even though a trend towards fewer renal flares in the MMF group (19% vs. 25% in the AZA group) was reported . More recently, in a larger trial, MMF was superior to AZA with respect to maintaining a renal response and preventing relapse in patients with lupus nephritis .
B-cell depleting therapy with anti-CD20 antibody rituximab (RTX) proved efficient in patients with active SLE including patients with lupus nephritis, who were nonresponsive to standard immunosuppressive therapy . In proof of the efficacy of RTX treatment in moderately to severely active SLE and lupus nephritis, two large multi-center trials were conducted. The EXPLORER trial (moderate to severe active SLE) demonstrated no difference in primary/secondary end points between RTX and placebo. In a subgroup analysis a beneficial effect of RTX was observed in the African-American/Hispanic subgroup . In patients with proliferative lupus nephritis and background immunosuppression (MMF) no difference was noted when RTX was added with regard to safety and efficacy (LUNAR trial)  even though opportunistic infections are reported to be rather common in SLE patients related to RTX treatment . Enthusiasm was also dampened by reports on the development of progressive multifocal leukoencephalopathy in SLE patients following treatment with RTX .
Novel approaches with focus on targeted therapy have been developed and are currently being evaluated in clinical trials. Circulating B-lymphocyte stimulator (BLyS) is elevated in SLE, and titers correlate with increased disease activity and elevated dsDNA antibody concentrations . Patients with serologically active SLE responded significantly better to belimumab, an antibody that binds to BLyS and inhibits its biological activity, plus standard of care (SOC) than to SOC alone . The efficacy of belimumab was further corroborated in two large phase III trials, BLISS 52  and BLISS 76 . In both trials, belimumab met its primary efficacy end point and was consequently approved by the FDA in the treatment of SLE with the exception of severe active lupus nephritis or central nervous system lupus. Further investigations addressed to evaluate the role in active lupus nephritis are necessary.
Promising results have been obtained in a phase II trial for epratuzumab, a humanized anti-CD22 antibody [108, 109]. Atacicept, a soluble receptor fusion protein, neutralizes the activity of BLyS and a proliferation-inducing ligand (APRIL) and their heterotrimers . In a phase I trial, atacicept was well tolerated and demonstrated a dose-dependent reduction of immunoglobulin levels and mature/total B cell numbers . However, in patients with active lupus nephritis, a phase II trial was terminated due to an increased number of infections . Further trials assessing the efficacy and safety are currently ongoing.
In patients with highly active lupus nephritis with failure of conventional therapy, short-term as well as prolonged immuno-adsorption led to a significant reduction in proteinuria and to sustained remission rates . Autologous stem cell transplantation achieved sustained clinical remissions in patients refractory to conventional immunosuppressive treatment, even though this clinical benefit was associated with increased mortality rates in most studies conducted so far . Intravenous immunoglobulins have shown benefits in patients nonresponsive to other therapies and as a steroid-sparing agent .
The histopathologic classification of lupus nephritis still guides the therapy. In proliferative lupus nephritis (III and IV), CYC and MMF have shown almost identical therapeutic responses as induction therapy in large trials. CSA might be an alternative to these immunosuppressive agents in pure class V lupus nephritis. In patients not responding to initial treatment, multi-target therapy might be an effective alternative. MMF seems to be superior to AZA in maintaining remission. The role of RTX in the treatment of lupus nephritis has to be further elucidated, as well as the significance of novel therapeutic approaches in the therapy of lupus nephritis.
Kidney disease in antiphospholipid syndrome
Antiphospholipid syndrome (APS) is defined by the association of vascular thrombosis potentially affecting all segments of the vascular bed, complications during pregnancy (including unexplained consecutive spontaneous abortions, premature births because of severe preeclampsia, eclampsia or placental insufficiency or unexplained death before the 10th week of gestation), and the presence of antiphospholipid antibodies (aPL), namely anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC) . The APS is classified as primary APS in the absence of associated autoimmune disease, whereas secondary APS is found alongside other autoimmune disorders .
Renal manifestations in the context of APS may result from thrombosis occurring at any location in the renal vasculature. Renal artery stenosis (RAS) is a common complication of APS, leading to renovascular hypertension . In a retrospective study, patients with APS, RAS and hypertension receiving oral anticoagulation with a target trough International Normalized Ratio (INR) >3.0 had better blood pressure control and renal function remained stable or improved, while in patients with an INR <3.0 renal function significantly deteriorated and blood pressure was poorly controlled . Arterial hypertension is a well-documented complication of APS. In a series of patients with primary APS, a large proportion of patients presented with hypertension, which was attributed to biopsy-proven vascular nephropathy . Kleinknecht et al. reported that all patients had severe hypertension and renal insufficiency in a small cohort of patients with secondary APS due to SLE . Thrombosis of the renal vein and inferior vena cava usually presents with nephrotic-range proteinuria in primary and secondary APS , especially in those with circulating LAC . APSN refers to kidney damage caused by intrarenal vascular damage and may be acute, in case of the presence of thrombotic microangiopathy, and/or chronic, in the case of arteriosclerosis, fibrous intimal hyperplasia and focal cortical atrophy [119, 123]. Thrombotic microangiopathy is characterized by distinctive microscopic and ultrastructural changes and clinical presentation commonly includes hypertension, mild to nephrotic-range proteinuria and renal impairment [119, 123]. Tektonidou et al. examined kidney biopsies obtained from patients with SLE with or without presence of aPL. APSN was detected in almost 40% with aPL, compared with only 4.3% of patients without aPL . Fakhouri et al. examined 29 kidney biopsies of patients with APS . In nine of these biopsies predominant pathological features distinct from ASPN were noted: membranous nephropathy (three cases), minimal-change disease/focal segmental glomerulosclerosis (three cases), mesangial c3 nephropathy (two cases), and pauci-immune crescentic glomerulonephritis (one case). Furthermore, a case of fibrillary glomerulonephritis in a patient with APS was published recently . Interestingly, the presence of aPL in patients undergoing renal transplantation significantly increases the risk of renal vascular thrombosis and graft failure [126, 127].
Blood pressure control is the key intervention in the treatment of APS-related renal involvement. Adequate anticoagulation (if evidence of microthrombi is present) has shown encouraging results in small cohorts and may prevent progression to end-stage renal disease . Evidence supporting immunosuppressive therapy in these patients is limited to case series [125, 129] and is not routinely recommended in APS-related renal manifestations. Contrasting, patients with catastrophic APS, which is characterized by severe multiple organ dysfunction in consequence of diffuse small vessel ischemia and thromboses predominantly affecting the parenchymal organs, usually receive a combination therapy, including anticoagulation, steroids, intravenous immunoglobulins and plasmapheresis, but despite this aggressive approach mortality is still high .
Blood pressure control is mandatory in patients with APSN. The role of anticoagulation with a target through INR above 3.0 in patients with APSN and microthrombi to prevent kidney function deterioration has to be elucidated in further, larger studies.
RA is characterized by persistent synovial, systemic inflammation and autoantibodies (particularly to rheumatoid factor and citrullinated peptides). Genetic as well as environmental factors contribute to the risk of developing RA . Renal involvement is relatively common in patients with RA.
A study of renal biopsy specimens indicated that mesangial glomerulonephritis is the predominant histopathologic finding in RA, followed by amyloidosis, membranous nephropathy, focal proliferative glomerulonephritis, minimal-change nephropathy and acute interstitial nephritis . Development of membranous nephropathy is related either to therapy with disease modifying antirheumatic drugs (DMARDs), in particular gold thiomalate, D-penicillamine and bucillamine , and anti-TNF alpha therapy, such as etanercept and adalimumab [133, 134], or rarely occurs concomitant with RA . Secondary AA amyloidosis was prevalent in 5.8% of patients with RA and was accompanied by a shortened life expectancy . Deposition of amyloid in renal tissue correlated significantly with parameters of renal function , while a lack of amyloid deposition in the glomerulus may characterize subjects with stable renal function . Mesangial glomerulonephritis is probably related to RA itself, since its occurrence was associated with higher titers of rheumatoid factor (RF) when compared with RA patients without nephropathy. Deposition of mesangial IgA correlated with the duration of RA and elevated serum IgA levels, whereas mesangial IgM deposition was correlated with serum levels of IgM class RF . In addition, single reports reveal the presence of FSGS  and fibrillary glomerulonephritis  in RA patients. Anti-TNF alpha therapy can be causative for the development of necrotizing crescentic glomerulonephritis and proliferative lupus nephritis [141, 142]. Besides the renal side effects of gold salts, D-penicillamine and bucillamine, CSA as another DMARD has a serious potential for renal toxicity, which is manifested primarily in a decline in creatinine clearance .
Improvement of clinical and laboratory parameters was achieved in most cases after drug withdrawal and in case of necessary initiation of immunosuppression [133, 134, 142, 143]. In patients with amyloid deposition, etanercept treatment reduced proteinuria as well as serum amyloid A. Furthermore, it entailed a decrease in serum creatinine in patients with creatinine values <2.0 mg/dl at the onset of amyloidosis .
Therapy related deterioration of kidney function has to be excluded in patients with RA. In addition, the persisting inflammation can lead to deposition of amyloid. Thus, adequate therapy to reduce disease activity may be effective in preventing this late-onset complication. Specific therapeutic interventions should be tailored to the underlying histologic kidney involvement.
Conclusion and future directions
Renal involvement is frequently present in CTDs and has variable phenotypes. Since there is a steady increase of knowledge regarding the pathophysiology behind auto-immune disorders, more specific therapeutic approaches have been developed and are currently in clinical trials.
Acute or chronic TIN is the predominant kidney biopsy finding in Sjögren syndrome. Kidney function normalizes in most cases after corticosteroids are initiated [2, 6]. In addition, several glomerular lesion patterns have been described in Sjögren syndrome.
Results from hematopoietic stem cell transplantation (HSCT) in SSc are promising. Current studies, namely the SCOT and ASTIS trials, have completed patient recruitment and the first results are expected soon . The ASSIST trial clearly depicted the efficacy of HSCT in patients with scleroderma, since all 10 patients in the HSCT-group improved when compared to none in the CYC–treated cohort . In addition, endothelin receptor antagonists in combination with dual blockade of the renin-angiotensin-aldosterone system (RAAS) significantly reduced proteinuria and stabilized the serum creatinine level after an initial increase in a patient with SRC . Despite efficacy in patients with pulmonary arterial hypertension in SSc , trials with the aim to show benefits of endothelin receptor antagonists in SRC have yet to be conducted.
Diverse glomerular alterations and rhabdomyolysis have been reported in patients with auto-immune myopathies. Guided therapy with the aim to treat the underlying disease improves kidney function in most cases.
In SLE, new therapeutic approaches have gained attention. One of these novel agents is belimumab, an inhibitor of serum BLyS, which was recently approved by the FDA for treatment of SLE with the exception of active lupus nephritis and central nervous system involvement. A randomized, controlled trial with inclusion of active lupus nephritis is currently being designed. Furthermore, BLyS inhibition may also be effective in the treatment of PSS, since patients with Sjögren syndrome exhibit increased BLyS levels . In patients with SLE, B-cell depleting therapy with RTX was effective in a larger cohort including patients with lupus nephritis , and efficacy was furthermore confirmed in a recent meta-analysis evaluating patients with refractory lupus nephritis . However, RTX failed to show superiority in two large phase III trials with patients either presenting without renal involvement (EXPLORER) or with renal involvement (LUNAR) [100, 101] even though a post hoc analysis of the EXPLORER trial indicated that RTX-treated patients achieved lower disease activity without a subsequent severe disease flare when compared to those treated with placebo . Persistent B-cell presence was associated with no clinical response following RTX treatment . In addition, physicians should be aware of severe infectious complications following RTX treatment in SLE patients [102, 103]. Despite other strategies, such as immunoglobulin administration, immuno-adsorption and stem cell transplantation [112–114], RTX is nevertheless one alternative in refractory SLE .
APS-related renal manifestation potentially affects any segment of the vascular bed and is commonly accompanied by arterial hypertension. Blood pressure control is crucial, whereas the role and the target level of oral anticoagulation needs to be further elucidated. Chronic inflammation, as well as drug related adverse effects, is causative of kidney involvement in RA. Etanercept has shown encouraging results in reduction of serum amyloid A in amyloidosis and patients with a baseline serum creatinine below 2 mg/dl tended to show a benefit following TNF-alpha inhibition .
Based on studies in non-diabetic nephropathy, patients with renal involvement in CTDs should receive RAAS blocking agents once proteinuria is >1 g/day [149, 150]. Renal function needs to be monitored as well as serum potassium levels and blood pressure. In chronic kidney disease in the pre-dialysis state the lowering of LDL-cholesterol safely reduced the risk of major atherosclerotic events . Accelerated atherosclerosis is a common finding in patients with chronic inflammation and in CTDs in particular . Thus, modification of the risk factors contributing to the evolution of cardiovascular disease is crucial in these patients. Moreover, adherence to therapeutic advice may be an underestimated problem, since a recent study indicated that only one-quarter of patients with SLE had an adherence rate ≥80% . In addition, counselling against smoking should be mandatory in patients with SLE and RA .
Suggested kidney biopsy indications in connective tissue diseases
rapid deterioration of renal function (exclude post renal and pre renal disorders first)
proteinuria >1 g/d (measured by collecting urine; collection over the course of a 24-hour period; to begin urine collection, the patient voids and discards the urine already in the bladder, afterwards urine for the next 24 hours has to be collected to ensure accurate results), if other causes of proteinuria are ruled out
the EULAR/ERA-EDTA recommendations for the management of lupus nephritis suggest performing a renal biopsy if reproducible proteinuria >0.5 g/d is present (especially with glomerular hematuria and/or cellular cases) 
nephritic urine sediment (red blood cell casts) with deterioration of kidney function (estimated GFR <60 ml/min) if pre-existing impaired renal function is ruled out
increase in proteinuria/serum creatinine despite ongoing immunosuppressive therapy (exclude post-renal and pre-renal disorders first); consider a repeat kidney biopsy due to potential phenotype change (for example, lupus nephritis)
suspected interstitial nephritis, findings of white blood cell casts; leukocyturia (due to proton pump inhibitors, non-steroidal anti-rheumatic drugs, Sjögren syndrome, rheumatoid arthritis, and so on)
diagnostic approach in case of uncertainties, when kidney involvement is suspected, but absolute indications are not met
American college of rheumatology
A proliferation-inducing ligand
Antiphospholipid syndrome nephropathy
Connective tissue disease
Connective tissue growth factor
Disease modifying antirheumatic drug
Double-stranded DNA antibodies
Epithelial to mesenchymal transition
Food and drug administration
Focal segmental glomerulosclerosis
Hematopoietic stem cell transplantation
International normalized ratio
International society of nephrology
Primary sjögren syndrome
Renal artery stenosis
Renal pathology society
Renal tubular acidosis
Systemic lupus erythematosus
Scleroderma renal crisis
Standard of care
Transforming growth factor ß
United network of organ sharing.
- Goules A, Masouridi S, Tzioufas AG, Ioannidis JP, Skopouli FN, Moutsopoulos HM: Clinically significant and biopsy-documented renal involvement in primary Sjogren syndrome. Medicine (Baltimore). 2000, 79: 241-249.Google Scholar
- Bossini N, Savoldi S, Franceschini F, Mombelloni S, Baronio M, Cavazzana I, Viola BF, Valzorio B, Mazzucchelli C, Cattaneo R, Scolari F, Maiorca R: Clinical and morphological features of kidney involvement in primary Sjogren's syndrome. Nephrol Dial Transplant. 2001, 16: 2328-2336.PubMedGoogle Scholar
- Penn H, Howie AJ, Kingdon EJ, Bunn CC, Stratton RJ, Black CM, Burns A, Denton CP: Scleroderma renal crisis: patient characteristics and long-term outcomes. QJM. 2007, 100: 485-494.PubMedGoogle Scholar
- Seshan SV, Jennette JC: Renal disease in systemic lupus erythematosus with emphasis on classification of lupus glomerulonephritis: advances and implications. Arch Pathol Lab Med. 2009, 133: 233-248.PubMedGoogle Scholar
- Sinico RA, Cavazzana I, Nuzzo M, Vianelli M, Napodano P, Scaini P, Tincani A: Renal involvement in primary antiphospholipid syndrome: retrospective analysis of 160 patients. Clin J Am Soc Nephrol. 2010, 5: 1211-1217.PubMedPubMed CentralGoogle Scholar
- Maripuri S, Grande JP, Osborn TG, Fervenza FC, Matteson EL, Donadio JV, Hogan MC: Renal involvement in primary Sjogren's syndrome: a clinicopathologic study. Clin J Am Soc Nephrol. 2009, 4: 1423-1431.PubMedPubMed CentralGoogle Scholar
- Ren H, Wang WM, Chen XN, Zhang W, Pan XX, Wang XL, Lin Y, Zhang S, Chen N: Renal involvement and followup of 130 patients with primary Sjogren's syndrome. J Rheumatol. 2008, 35: 278-284.PubMedGoogle Scholar
- Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M: Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol. 1998, 110: 47-51.PubMedGoogle Scholar
- Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Grotendorst GR, Takehara K: Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J Invest Dermatol. 1995, 105: 280-284.PubMedGoogle Scholar
- Mouthon L, Mehrenberger M, Teixeira L, Fakhouri F, Berezne A, Guillevin L, Noel LH: Endothelin-1 expression in scleroderma renal crisis. Hum Pathol. 2011, 42: 95-102.PubMedGoogle Scholar
- Helfrich DJ, Banner B, Steen VD, Medsger TA: Normotensive renal failure in systemic sclerosis. Arthritis Rheum. 1989, 32: 1128-1134.PubMedGoogle Scholar
- Teixeira L, Mouthon L, Mahr A, Berezne A, Agard C, Mehrenberger M, Noel LH, Trolliet P, Frances C, Cabane J, Guillevin L: Mortality and risk factors of scleroderma renal crisis: a French retrospective study of 50 patients. Ann Rheum Dis. 2008, 67: 110-116.PubMedGoogle Scholar
- Batal I, Domsic RT, Medsger TA, Bastacky S: Scleroderma renal crisis: a pathology perspective. Int J Rheumatol. 2010, 2010: 543704.PubMedPubMed CentralGoogle Scholar
- Yen TH, Lai PC, Chen CC, Hsueh S, Huang JY: Renal involvement in patients with polymyositis and dermatomyositis. Int J Clin Pract. 2005, 59: 188-193.PubMedGoogle Scholar
- Joshi D, Kumar N, Rai A: Dermatomyositis presenting with rhabdomyolysis and acute renal failure; an uncommon manifestation. Ann Indian Acad Neurol. 2009, 12: 45-47.PubMedPubMed CentralGoogle Scholar
- Tektonidou MG, Sotsiou F, Nakopoulou L, Vlachoyiannopoulos PG, Moutsopoulos HM: Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome. Arthritis Rheum. 2004, 50: 2569-2579.PubMedGoogle Scholar
- Helin HJ, Korpela MM, Mustonen JT, Pasternack AI: Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis. Arthritis Rheum. 1995, 38: 242-247.PubMedGoogle Scholar
- Ooms V, Decupere M, Lerut E, Vanrenterghem Y, Kuypers DR: Secondary renal amyloidosis due to long-standing tubulointerstitial nephritis in a patient with Sjogren syndrome. Am J Kidney Dis. 2005, 46: e75-e80.PubMedGoogle Scholar
- Roguedas AM, Youinou P, Lemasson G, Pennec YL, Misery L: Primary Gougerot-Sjogren syndrome: a dermatological approach. J Eur Acad Dermatol Venereol. 2006, 20: 243-247.PubMedGoogle Scholar
- Manthorpe R, Asmussen K, Oxholm P: Primary Sjogren's syndrome: diagnostic criteria, clinical features, and disease activity. J Rheumatol Suppl. 1997, 50: 8-11.PubMedGoogle Scholar
- Rehman HU: Sjogren's syndrome. Yonsei Med J. 2003, 44: 947-954.PubMedGoogle Scholar
- Yilmaz H, Kaya M, Ozbek M, Ureten K, Safa Yildirim I: Hypokalemic periodic paralysis in Sjogren's syndrome secondary to distal renal tubular acidosis. Rheumatol Int. 2012, Epub ahead of printGoogle Scholar
- Kobayashi T, Muto S, Nemoto J, Miyata Y, Ishiharajima S, Hironaka M, Asano Y, Kusano E: Fanconi's syndrome and distal (type 1) renal tubular acidosis in a patient with primary Sjogren's syndrome with monoclonal gammopathy of undetermined significance. Clin Nephrol. 2006, 65: 427-432.PubMedGoogle Scholar
- Yang ML, Kuo MC, Ou TT, Chen HC: Primary Sjogren's syndrome with minimal change disease–a case report. Kaohsiung J Med Sci. 2011, 27: 190-194.PubMedGoogle Scholar
- Aasarod K, Haga HJ, Berg KJ, Hammerstrom J, Jorstad S: Renal involvement in primary Sjogren's syndrome. QJM. 2000, 93: 297-304.PubMedGoogle Scholar
- Pessler F, Emery H, Dai L, Wu YM, Monash B, Cron RQ, Pradhan M: The spectrum of renal tubular acidosis in paediatric Sjogren syndrome. Rheumatology (Oxford). 2006, 45: 85-91.Google Scholar
- Hunzelmann N, Krieg T: Scleroderma: from pathophysiology to novel therapeutic approaches. Exp Dermatol. 2010, 19: 393-400.PubMedGoogle Scholar
- Strange G, Nash P: The manifestations of vasculopathy in systemic sclerosis and its evidence-based therapy. Int J Rheum Dis. 2009, 12: 192-206.PubMedGoogle Scholar
- Walker UA, Tyndall A, Czirjak L, Denton C, Farge-Bancel D, Kowal-Bielecka O, Muller-Ladner U, Bocelli-Tyndall C, Matucci-Cerinic M: Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR scleroderma trials and research group database. Ann Rheum Dis. 2007, 66: 754-763.PubMedPubMed CentralGoogle Scholar
- Liu Y: New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol. 2010, 21: 212-222.PubMedGoogle Scholar
- Postlethwaite AE, Shigemitsu H, Kanangat S: Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis. Curr Opin Rheumatol. 2004, 16: 733-738.PubMedGoogle Scholar
- Steen VD, Medsger TA, Osial TA, Ziegler GL, Shapiro AP, Rodnan GP: Factors predicting development of renal involvement in progressive systemic sclerosis. Am J Med. 1984, 76: 779-786.PubMedGoogle Scholar
- Nguyen B, Mayes MD, Arnett FC, Del Junco D, Reveille JD, Gonzalez EB, Draeger HT, Perry M, Hendiani A, Anand KK, Assassi S: HLA-DRB1*0407 and *1304 are risk factors for scleroderma renal crisis. Arthritis Rheum. 2011, 63: 530-534.PubMedPubMed CentralGoogle Scholar
- Steen VD, Medsger TA: Case–control study of corticosteroids and other drugs that either precipitate or protect from the development of scleroderma renal crisis. Arthritis Rheum. 1998, 41: 1613-1619.PubMedGoogle Scholar
- Arad U, Balbir-Gurman A, Doenyas-Barak K, Amit-Vazina M, Caspi D, Elkayam O: Anti-neutrophil antibody associated vasculitis in systemic sclerosis. Semin Arthritis Rheum. 2011, 41: 223-229.PubMedGoogle Scholar
- Bussone G, Berezne A, Pestre V, Guillevin L, Mouthon L: The scleroderma kidney: progress in risk factors, therapy, and prevention. Curr Rheumatol Rep. 2011, 13: 37-43.PubMedGoogle Scholar
- Steen VD, Medsger TA: Long-term outcomes of scleroderma renal crisis. Ann Intern Med. 2000, 133: 600-603.PubMedGoogle Scholar
- Pham PT, Pham PC, Danovitch GM, Gritsch HA, Singer J, Wallace WD, Hayashi R, Wilkinson AH: Predictors and risk factors for recurrent scleroderma renal crisis in the kidney allograft: case report and review of the literature. Am J Transplant. 2005, 5: 2565-2569.PubMedGoogle Scholar
- Denton CP, Sweny P, Abdulla A, Black CM: Acute renal failure occurring in scleroderma treated with cyclosporin A: a report of three cases. Br J Rheumatol. 1994, 33: 90-92.PubMedGoogle Scholar
- Mammen AL: Dermatomyositis and polymyositis: clinical presentation, autoantibodies, and pathogenesis. Ann N Y Acad Sci. 2010, 1184: 134-153.PubMedGoogle Scholar
- Clarke JT, Werth VP: Rheumatic manifestations of skin disease. Curr Opin Rheumatol. 2010, 22: 78-84.PubMedPubMed CentralGoogle Scholar
- Kuo CF, See LC, Yu KH, Chou IJ, Chang HC, Chiou MJ, Luo SF: Incidence, cancer risk and mortality of dermatomyositis and polymyositis in Taiwan: a nationwide population study. Br J Dermatol. 2011, 165: 1273-1279.PubMedGoogle Scholar
- Chen YJ, Wu CY, Huang YL, Wang CB, Shen JL, Chang YT: Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan. Arthritis Res Ther. 2010, 12: R70.PubMedPubMed CentralGoogle Scholar
- Stockton D, Doherty VR, Brewster DH: Risk of cancer in patients with dermatomyositis or polymyositis, and follow-up implications: a Scottish population-based cohort study. Br J Cancer. 2001, 85: 41-45.PubMedPubMed CentralGoogle Scholar
- Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR, Felson DT: Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet. 2001, 357: 96-100.PubMedGoogle Scholar
- Frost NA, Morand EF, Hall CL, Maddison PJ, Bhalla AK: Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. Br J Rheumatol. 1993, 32: 929-931.PubMedGoogle Scholar
- Valenzuela OF, Reiser IW, Porush JG: Idiopathic polymyositis and glomerulonephritis. J Nephrol. 2001, 14: 120-124.PubMedGoogle Scholar
- Takizawa Y, Kanda H, Sato K, Kawahata K, Yamaguchi A, Uozaki H, Shimizu J, Tsuji S, Misaki Y, Yamamoto K: Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes. Clin Rheumatol. 2007, 26: 792-796.PubMedGoogle Scholar
- Xie Q, Liu Y, Liu G, Yang N, Yin G: Diffuse proliferative glomerulonephritis associated with dermatomyositis with nephrotic syndrome. Rheumatol Int. 2010, 30: 821-825.PubMedGoogle Scholar
- Dyck RF, Katz A, Gordon DA, Johnson M, Shainhouse Z, Cardella CJ, Bear RA: Glomerulonephritis associated with polymyositis. J Rheumatol. 1979, 6: 336-344.PubMedGoogle Scholar
- Carleton H, Pitts W, Davidson W, Roth P: Muscle disease associated with renal failure. Arch Intern Med. 1977, 137: 939-941.PubMedGoogle Scholar
- Moutsopoulos H, Fye KH: Letter: Lipoid nephrosis and focal glomerulosclerosis in a patient with polymyositis. Lancet. 1975, 1: 1039.PubMedGoogle Scholar
- Hara I, Kurata N, Hyozu K, Tamao H: A case of polymyositis complicated with membranous nephritis. Nippon Naika Gakkai Zasshi. 1991, 80: 108-109.PubMedGoogle Scholar
- Tsunemi M, Ishimura E, Tsumura K, Shoji S, Sugimura T, Nishizawa Y, Morii H: A case of crescentic glomerulonephritis associated with polymyositis. Nephron. 1993, 64: 488-489.PubMedGoogle Scholar
- Fukui H, Kimura T, Nakabayashi K, Nagasawa T: Dermatomyositis associated with immune-complex type nephritis induced by tubular epithelial antigen. Nihon Jinzo Gakkai Shi. 1976, 18: 523-533.PubMedGoogle Scholar
- Moriyama T, Uruta Y, Yamaguchi H, Fukuzaki M, Uchida Y, Yasumoto Y, Yamashita W, Harada R, Ohsaki K, Nakajima A: A case of immune-complex type glomerulonephritis associated with dermatomyositis. Nippon Naika Gakkai Zasshi. 1989, 78: 994-995.PubMedGoogle Scholar
- Makino H, Hirata K, Matsuda M, Amano T, Ota Z: Membranous nephropathy developing during the course of dermatomyositis. J Rheumatol. 1994, 21: 1377-1378.PubMedGoogle Scholar
- Yen TH, Huang JY, Chen CY: Unexpected IgA nephropathy during the treatment of a young woman with idiopathic dermatomyositis: case report and review of the literature. J Nephrol. 2003, 16: 148-153.PubMedGoogle Scholar
- Kamata K, Kobayashi Y, Shigematsu H, Saito T: Childhood type polymyositis and rapidly progressive glomerulonephritis. Acta Pathol Jpn. 1982, 32: 801-806.PubMedGoogle Scholar
- Hochberg MC: Updating the american college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997, 40: 1725.PubMedGoogle Scholar
- Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, Mejia JC, Aydintug AO, Chwalinska-Sadowska H, de Ramon E, Fernandez-Nebro A, Galeazzi M, Valen M, Mathieu A, Houssiau F, Caro N, Alba P, Ramos-Casals M, Ingelmo M, Hughes GR: Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). 2003, 82: 299-308.Google Scholar
- Doria A, Iaccarino L, Ghirardello A, Zampieri S, Arienti S, Sarzi-Puttini P, Atzeni F, Piccoli A, Todesco S: Long-term prognosis and causes of death in systemic lupus erythematosus. Am J Med. 2006, 119: 700-706.PubMedGoogle Scholar
- Pons-Estel GJ, Alarcon GS, Scofield L, Reinlib L, Cooper GS: Understanding the epidemiology and progression of systemic lupus erythematosus. Semin Arthritis Rheum. 2010, 39: 257-268.PubMedGoogle Scholar
- Rubtsov AV, Rubtsova K, Kappler JW, Marrack P: Genetic and hormonal factors in female-biased autoimmunity. Autoimmun Rev. 2010, 9: 494-498.PubMedPubMed CentralGoogle Scholar
- Cooper GS, Wither J, Bernatsky S, Claudio JO, Clarke A, Rioux JD, Fortin PR: Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents. Rheumatology (Oxford). 2010, 49: 2172-2180.Google Scholar
- van Bavel CC, Fenton KA, Rekvig OP, van der Vlag J, Berden JH: Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus. Arthritis Rheum. 2008, 58: 1892-1899.PubMedGoogle Scholar
- Dieker JW, van der Vlag J, Berden JH: Triggers for anti-chromatin autoantibody production in SLE. Lupus. 2002, 11: 856-864.PubMedGoogle Scholar
- Espeli M, Bokers S, Giannico G, Dickinson HA, Bardsley V, Fogo AB, Smith KG: Local renal autoantibody production in lupus nephritis. J Am Soc Nephrol. 2011, 22: 296-305.PubMedPubMed CentralGoogle Scholar
- Egner W: The use of laboratory tests in the diagnosis of SLE. J Clin Pathol. 2000, 53: 424-432.PubMedPubMed CentralGoogle Scholar
- Aggarwal R, Sestak AL, D'Sousa A, Dillon SP, Namjou B, Scofield RH: Complete complement deficiency in a large cohort of familial systemic lupus erythematosus. Lupus. 2010, 19: 52-57.PubMedGoogle Scholar
- Julkunen H, Ekblom-Kullberg S, Miettinen A: Nonrenal and renal activity of systemic lupus erythematosus: a comparison of two anti-C1q and five anti-dsDNA assays and complement C3 and C4. Rheumatol Int. 2012, 32: 2445-2451.PubMedGoogle Scholar
- Bertsias GK, Tektonidou M, Amoura Z, Aringer M, Bajema I, Berden JH, Boletis J, Cervera R, Dorner T, Doria A, Ferrario F, Floege J, Houssiau F, Ioannidis JP, Isenberg DA, Kallenberg CG, Lightstone L, Marks SD, Martini A, Moroni G, Neumann I, Praga M, Schneider M, Starra A, Tesar V, Vasconcelos C, van Vollenhoven RF, Zakharova H, Haubitz M, Gordon C: Joint european league against rheumatism and european renal association-european dialysis and transplant association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012, 71: 1771-1782.PubMedPubMed CentralGoogle Scholar
- Birmingham DJ, Irshaid F, Nagaraja HN, Zou X, Tsao BP, Wu H, Yu CY, Hebert LA, Rovin BH: The complex nature of serum C3 and C4 as biomarkers of lupus renal flare. Lupus. 2010, 19: 1272-1280.PubMedPubMed CentralGoogle Scholar
- Oelzner P, Deliyska B, Funfstuck R, Hein G, Herrmann D, Stein G: Anti-C1q antibodies and antiendothelial cell antibodies in systemic lupus erythematosus - relationship with disease activity and renal involvement. Clin Rheumatol. 2003, 22: 271-278.PubMedGoogle Scholar
- Akhter E, Burlingame RW, Seaman AL, Magder L, Petri M: Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers. Lupus. 2011, 20: 1267-1274.PubMedGoogle Scholar
- Katsumata Y, Miyake K, Kawaguchi Y, Okamoto Y, Kawamoto M, Gono T, Baba S, Hara M, Yamanaka H: Anti-C1q antibodies are associated with systemic lupus erythematosus global activity but not specifically with nephritis: a controlled study of 126 consecutive patients. Arthritis Rheum. 2011, 63: 2436-2444.PubMedGoogle Scholar
- Zabaleta-Lanz ME, Munoz LE, Tapanes FJ, Vargas-Arenas RE, Daboin I, Barrios Y, Pinto JA, Bianco NE: Further description of early clinically silent lupus nephritis. Lupus. 2006, 15: 845-851.PubMedGoogle Scholar
- Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M: The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol. 2004, 15: 241-250.PubMedGoogle Scholar
- Gupta R, Sharma A, Bhowmik D, Gupta S, Agarwal S, Dinda A: Collapsing glomerulopathy occurring in HIV-negative patients with systemic lupus erythematosus: report of three cases and brief review of the literature. Lupus. 2011, 20: 866-870.PubMedGoogle Scholar
- Mac-Moune Lai F, Li EK, Tang NL, Li PK, Lui SF, Lai KN: IgA nephropathy: a rare lesion in systemic lupus erythematosus. Mod Pathol. 1995, 8: 5-10.PubMedGoogle Scholar
- Baranowska-Daca E, Choi YJ, Barrios R, Nassar G, Suki WN, Truong LD: Nonlupus nephritides in patients with systemic lupus erythematosus: a comprehensive clinicopathologic study and review of the literature. Hum Pathol. 2001, 32: 1125-1135.PubMedGoogle Scholar
- Dube GK, Markowitz GS, Radhakrishnan J, Appel GB, D'Agati VD: Minimal change disease in systemic lupus erythematosus. Clin Nephrol. 2002, 57: 120-126.PubMedGoogle Scholar
- Kraft SW, Schwartz MM, Korbet SM, Lewis EJ: Glomerular podocytopathy in patients with systemic lupus erythematosus. J Am Soc Nephrol. 2005, 16: 175-179.PubMedGoogle Scholar
- de Carvalho JF, da Mota LM, Bonfa E: Fatal rhabdomyolysis in systemic lupus erythematosus. Rheumatol Int. 2011, 31: 1243-1245.PubMedGoogle Scholar
- Li SL, Liou LB, Fang JT, Tsai WP: Symptomatic renal tubular acidosis (RTA) in patients with systemic lupus erythematosus: an analysis of six cases with new association of type 4 RTA. Rheumatology (Oxford). 2005, 44: 1176-1180.Google Scholar
- Duran-Barragan S, McGwin G, Vila LM, Reveille JD, Alarcon GS: Angiotensin-converting enzyme inhibitors delay the occurrence of renal involvement and are associated with a decreased risk of disease activity in patients with systemic lupus erythematosus–results from LUMINA (LIX): a multiethnic US cohort. Rheumatology (Oxford). 2008, 47: 1093-1096.Google Scholar
- Siso A, Ramos-Casals M, Bove A, Brito-Zeron P, Soria N, Munoz S, Testi A, Plaza J, Sentis J, Coca A: Previous antimalarial therapy in patients diagnosed with lupus nephritis: influence on outcomes and survival. Lupus. 2008, 17: 281-288.PubMedGoogle Scholar
- Bomback AS, Appel GB: Updates on the treatment of lupus nephritis. J Am Soc Nephrol. 2010, 21: 2028-2035.PubMedGoogle Scholar
- Houssiau FA, Vasconcelos C, D'Cruz D, Sebastiani GD, Garrido Ed Ede R, Danieli MG, Abramovicz D, Blockmans D, Mathieu A, Direskeneli H, Galeazzi M, Gul A, Levy Y, Petera P, Popovic R, Petrovic R, Sinico RA, Cattaneo R, Font J, Depresseux G, Cosyns JP, Cervera R: Immunosuppressive therapy in lupus nephritis: the euro-lupus nephritis trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum. 2002, 46: 2121-2131.PubMedGoogle Scholar
- Houssiau FA, Vasconcelos C, D'Cruz D, Sebastiani GD, de Ramon Garrido E, Danieli MG, Abramovicz D, Blockmans D, Cauli A, Direskeneli H, Galeazzi M, Gul A, Levy Y, Petera P, Popovic R, Petrovic R, Sinico RA, Cattaneo R, Font J, Depresseux G, Cosyns JP, Cervera R: The 10-year follow-up data of the euro-lupus nephritis trial comparing low-dose and high-dose intravenous cyclophosphamide. Ann Rheum Dis. 2010, 69: 61-64.PubMedGoogle Scholar
- Ginzler EM, Dooley MA, Aranow C, Kim MY, Buyon J, Merrill JT, Petri M, Gilkeson GS, Wallace DJ, Weisman MH, Appel GB: Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N Engl J Med. 2005, 353: 2219-2228.PubMedGoogle Scholar
- Appel GB, Contreras G, Dooley MA, Ginzler EM, Isenberg D, Jayne D, Li LS, Mysler E, Sanchez-Guerrero J, Solomons N, Wofsy D: Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. J Am Soc Nephrol. 2009, 20: 1103-1112.PubMedPubMed CentralGoogle Scholar
- Radhakrishnan J, Moutzouris DA, Ginzler EM, Solomons N, Siempos II, Appel GB: Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis. Kidney Int. 2010, 77: 152-160.PubMedGoogle Scholar
- Austin HA, Illei GG, Braun MJ, Balow JE: Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy. J Am Soc Nephrol. 2009, 20: 901-911.PubMedPubMed CentralGoogle Scholar
- Bao H, Liu ZH, Xie HL, Hu WX, Zhang HT, Li LS: Successful treatment of class V + IV lupus nephritis with multitarget therapy. J Am Soc Nephrol. 2008, 19: 2001-2010.PubMedPubMed CentralGoogle Scholar
- Contreras G, Tozman E, Nahar N, Metz D: Maintenance therapies for proliferative lupus nephritis: mycophenolate mofetil, azathioprine and intravenous cyclophosphamide. Lupus. 2005, 14: s33-s38.PubMedGoogle Scholar
- Houssiau FA, D'Cruz D, Sangle S, Remy P, Vasconcelos C, Petrovic R, Fiehn C, de Ramon Garrido E, Gilboe IM, Tektonidou M, Blockmans D, Ravelingien I, le Guern V, Depresseux G, Guillevin L, Cervera R: Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: results from the MAINTAIN nephritis trial. Ann Rheum Dis. 2010, 69: 2083-2089.PubMedPubMed CentralGoogle Scholar
- Dooley MA, Jayne D, Ginzler EM, Isenberg D, Olsen NJ, Wofsy D, Eitner F, Appel GB, Contreras G, Lisk L, Solomons N: Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis. N Engl J Med. 2011, 365: 1886-1895.PubMedGoogle Scholar
- Lu TY, Ng KP, Cambridge G, Leandro MJ, Edwards JC, Ehrenstein M, Isenberg DA: A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college london hospital: the first fifty patients. Arthritis Rheum. 2009, 61: 482-487.PubMedGoogle Scholar
- Merrill JT, Neuwelt CM, Wallace DJ, Shanahan JC, Latinis KM, Oates JC, Utset TO, Gordon C, Isenberg DA, Hsieh HJ, Zhang D, Brunetta PG: Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum. 2010, 62: 222-233.PubMedPubMed CentralGoogle Scholar
- Rovin BH, Furie R, Latinis K, Looney RJ, Fervenza FC, Sanchez-Guerrero J, Maciuca R, Zhang D, Garg JP, Brunetta P, Appel G: Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab (LUNAR) study. Arthritis Rheum. 2012, 64: 1215-1226.PubMedGoogle Scholar
- Tony HP, Burmester G, Schulze-Koops H, Grunke M, Henes J, Kotter I, Haas J, Unger L, Lovric S, Haubitz M, Fischer-Betz R, Chehab G, Rubbert-Roth A, Specker C, Weinerth J, Holle J, Muller-Ladner U, Konig R, Fiehn C, Burgwinkel P, Budde K, Sorensen H, Meurer M, Aringer M, Kieseier B, Erfurt-Berge C, Sticherling M, Veelken R, Ziemann U, Strutz F: Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID). Arthritis Res Ther. 2011, 13: R75.PubMedPubMed CentralGoogle Scholar
- Molloy ES, Calabrese LH: Progressive multifocal leukoencephalopathy: a national estimate of frequency in systemic lupus erythematosus and other rheumatic diseases. Arthritis Rheum. 2009, 60: 3761-3765.PubMedGoogle Scholar
- Petri M, Stohl W, Chatham W, McCune WJ, Chevrier M, Ryel J, Recta V, Zhong J, Freimuth W: Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum. 2008, 58: 2453-2459.PubMedGoogle Scholar
- Wallace DJ, Stohl W, Furie RA, Lisse JR, McKay JD, Merrill JT, Petri MA, Ginzler EM, Chatham WW, McCune WJ, Fernandez V, Chevrier MR, Zhong ZJ, Freimuth WW: A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum. 2009, 61: 1168-1178.PubMedPubMed CentralGoogle Scholar
- Navarra SV, Guzman RM, Gallacher AE, Hall S, Levy RA, Jimenez RE, Li EK, Thomas M, Kim HY, Leon MG, Tanasescu C, Nasonov E, Lan JL, Pineda L, Zhong ZJ, Freimuth W, Petri MA: Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet. 2011, 377: 721-731.PubMedGoogle Scholar
- Furie R, Petri M, Zamani O, Cervera R, Wallace DJ, Tegzova D, Sanchez-Guerrero J, Schwarting A, Merrill JT, Chatham WW, Stohl W, Ginzler EM, Hough DR, Zhong ZJ, Freimuth W, van Vollenhoven RF: A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus. Arthritis Rheum. 2011, 63: 3918-3930.PubMedGoogle Scholar
- Dorner T, Kaufmann J, Wegener WA, Teoh N, Goldenberg DM, Burmester GR: Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus. Arthritis Res Ther. 2006, 8: R74.PubMedPubMed CentralGoogle Scholar
- Yildirim-Toruner C, Diamond B: Current and novel therapeutics in the treatment of systemic lupus erythematosus. J Allergy Clin Immunol. 2011, 127: 303-312. quiz 313–304PubMedPubMed CentralGoogle Scholar
- Dillon SR, Harder B, Lewis KB, Moore MD, Liu H, Bukowski TR, Hamacher NB, Lantry MM, Maurer M, Krejsa CM, Ellsworth JL, Pederson S, Elkon KB, Wener MH, Dall'Era M, Gross JA: B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin. Arthritis Res Ther. 2010, 12: R48.PubMedPubMed CentralGoogle Scholar
- Dall'Era M, Chakravarty E, Wallace D, Genovese M, Weisman M, Kavanaugh A, Kalunian K, Dhar P, Vincent E, Pena-Rossi C, Wofsy D: Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum. 2007, 56: 4142-4150.PubMedGoogle Scholar
- Stummvoll GH, Schmaldienst S, Smolen JS, Derfler K, Biesenbach P: Lupus nephritis: prolonged immunoadsorption (IAS) reduces proteinuria and stabilizes global disease activity. Nephrol Dial Transplant. 2012, 27: 618-626.PubMedGoogle Scholar
- Illei GG, Cervera R, Burt RK, Doria A, Hiepe F, Jayne D, Pavletic S, Martin T, Marmont A, Saccardi R, Voskuyl AE, Farge D: Current state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosus. Ann Rheum Dis. 2011, 70: 2071-2074.PubMedPubMed CentralGoogle Scholar
- Toubi E, Kessel A, Shoenfeld Y: High-dose intravenous immunoglobulins: an option in the treatment of systemic lupus erythematosus. Hum Immunol. 2005, 66: 395-402.PubMedGoogle Scholar
- Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, Brey R, Derksen R, Harris EN, Hughes GR, Triplett DA, Khamashta MA: International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. 1999, 42: 1309-1311.PubMedGoogle Scholar
- Gigante A, Gasperini ML, Cianci R, Barbano B, Giannakakis K, Di Donato D, Fuiano G, Amoroso A: Antiphospholipid antibodies and renal involvement. Am J Nephrol. 2009, 30: 405-412.PubMedGoogle Scholar
- Sangle SR, D'Cruz DP, Jan W, Karim MY, Khamashta MA, Abbs IC, Hughes GR: Renal artery stenosis in the antiphospholipid (Hughes) syndrome and hypertension. Ann Rheum Dis. 2003, 62: 999-1002.PubMedPubMed CentralGoogle Scholar
- Sangle SR, D'Cruz DP, Abbs IC, Khamashta MA, Hughes GR: Renal artery stenosis in hypertensive patients with antiphospholipid (Hughes) syndrome: outcome following anticoagulation. Rheumatology (Oxford). 2005, 44: 372-377.Google Scholar
- Nochy D, Daugas E, Droz D, Beaufils H, Grunfeld JP, Piette JC, Bariety J, Hill G: The intrarenal vascular lesions associated with primary antiphospholipid syndrome. J Am Soc Nephrol. 1999, 10: 507-518.PubMedGoogle Scholar
- Kleinknecht D, Bobrie G, Meyer O, Noel LH, Callard P, Ramdane M: Recurrent thrombosis and renal vascular disease in patients with a lupus anticoagulant. Nephrol Dial Transplant. 1989, 4: 854-858.PubMedGoogle Scholar
- Uthman I, Khamashta M: Antiphospholipid syndrome and the kidneys. Semin Arthritis Rheum. 2006, 35: 360-367.PubMedGoogle Scholar
- Mintz G, Acevedo-Vazquez E, Gutierrez-Espinosa G, Avelar-Garnica F: Renal vein thrombosis and inferior vena cava thrombosis in systemic lupus erythematosus. Frequency and risk factors. Arthritis Rheum. 1984, 27: 539-544.PubMedGoogle Scholar
- Amigo MC: Kidney disease in antiphospholipid syndrome. Rheum Dis Clin North Am. 2006, 32: 509-522.PubMedGoogle Scholar
- Fakhouri F, Noel LH, Zuber J, Beaufils H, Martinez F, Lebon P, Papo T, Chauveau D, Bletry O, Grunfeld JP, Piette JC, Lesavre P: The expanding spectrum of renal diseases associated with antiphospholipid syndrome. Am J Kidney Dis. 2003, 41: 1205-1211.PubMedGoogle Scholar
- Javaid MM, Denley H, Tagboto S: Fibrillary glomerulonephritis with small fibrils in a patient with the antiphospholipid antibody syndrome successfully treated with immunosuppressive therapy. BMC Nephrol. 2007, 8: 7.PubMedPubMed CentralGoogle Scholar
- Wagenknecht DR, Fastenau DR, Torry RJ, Becker DG, LeFor WM, Carter CB, Haag BW, McIntyre JA: Risk of early renal allograft failure is increased for patients with antiphospholipid antibodies. Transpl Int. 2000, 13: S78-S81.PubMedGoogle Scholar
- Wagenknecht DR, Becker DG, LeFor WM, McIntyre JA: Antiphospholipid antibodies are a risk factor for early renal allograft failure. Transplantation. 1999, 68: 241-246.PubMedGoogle Scholar
- Dayal NA, Isenberg DA: Endstage renal failure in primary antiphospholipid syndrome–case report and review of literature. Rheumatology (Oxford). 2003, 42: 1128-1129.Google Scholar
- Korkmaz C, Kabukcuoglu S, Isiksoy S, Yalcin AU: Renal involvement in primary antiphospholipid syndrome and its response to immunosuppressive therapy. Lupus. 2003, 12: 760-765.PubMedGoogle Scholar
- Erkan D, Lockshin MD: New approaches for managing antiphospholipid syndrome. Nat Clin Pract Rheumatol. 2009, 5: 160-170.PubMedGoogle Scholar
- Scott DL, Wolfe F, Huizinga TW: Rheumatoid arthritis. Lancet. 2010, 376: 1094-1108.PubMedGoogle Scholar
- Kuroda T, Tanabe N, Kobayashi D, Wada Y, Murakami S, Nakano M, Narita I: Significant association between renal function and area of amyloid deposition in kidney biopsy specimens in reactive amyloidosis associated with rheumatoid arthritis. Rheumatol Int. 2012, 32: 3155-3162.PubMedGoogle Scholar
- Giordano A, Cencioni L, Salvo DP, Berrettini M: Membranous nephropathy secondary to rheumatoid arthritis occurring during anti-TNFalpha therapy and responsive to second-line treatment with rituximab. G Ital Nefrol. 2011, 28: 214-218.PubMedGoogle Scholar
- Maruotti N, Corrado A, Gaudio A, Cantatore FP: Membranous nephropathy in rheumatoid arthritis: a case report. Clin Exp Rheumatol. 2009, 27: 840-842.PubMedGoogle Scholar
- Honkanen E, Tornroth T, Pettersson E, Skrifvars B: Membranous glomerulonephritis in rheumatoid arthritis not related to gold or D-penicillamine therapy: a report of four cases and review of the literature. Clin Nephrol. 1987, 27: 87-93.PubMedGoogle Scholar
- Myllykangas-Luosujarvi R, Aho K, Kautiainen H, Hakala M: Amyloidosis in a nationwide series of 1666 subjects with rheumatoid arthritis who died during 1989 in Finland. Rheumatology (Oxford). 1999, 38: 499-503.Google Scholar
- Uda H, Yokota A, Kobayashi K, Miyake T, Fushimi H, Maeda A, Saiki O: Two distinct clinical courses of renal involvement in rheumatoid patients with AA amyloidosis. J Rheumatol. 2006, 33: 1482-1487.PubMedGoogle Scholar
- Korpela M, Mustonen J, Teppo AM, Helin H, Pasternack A: Mesangial glomerulonephritis as an extra-articular manifestation of rheumatoid arthritis. Br J Rheumatol. 1997, 36: 1189-1195.PubMedGoogle Scholar
- Gedalia A, Mendez EA, Craver R, Vehaskari M, Espinoza LR: Renal involvement in juvenile rheumatoid arthritis: report of two cases. Clin Rheumatol. 2001, 20: 153-156.PubMedGoogle Scholar
- Yun YS, Song HC, Lee K, Choi EJ, Kim YS, Min JK, Kim YK: Fibrillary glomerulonephritis in rheumatoid arthritis. Nephrology (Carlton). 2010, 15: 266-267.Google Scholar
- Kaneko K, Nanki T, Hosoya T, Mizoguchi F, Miyasaka N: Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis. Mod Rheumatol. 2010, 20: 632-636.PubMedGoogle Scholar
- Stokes MB, Foster K, Markowitz GS, Ebrahimi F, Hines W, Kaufman D, Moore B, Wolde D, D'Agati VD: Development of glomerulonephritis during anti-TNF-alpha therapy for rheumatoid arthritis. Nephrol Dial Transplant. 2005, 20: 1400-1406.PubMedGoogle Scholar
- Schiff MH, Whelton A: Renal toxicity associated with disease-modifying antirheumatic drugs used for the treatment of rheumatoid arthritis. Semin Arthritis Rheum. 2000, 30: 196-208.PubMedGoogle Scholar
- Nakamura T, Higashi S, Tomoda K, Tsukano M, Shono M: Etanercept can induce resolution of renal deterioration in patients with amyloid A amyloidosis secondary to rheumatoid arthritis. Clin Rheumatol. 2010, 29: 1395-1401.PubMedGoogle Scholar
- Tyndall A: Successes and failures of stem cell transplantation in autoimmune diseases. Hematology Am Soc Hematol Educ Program. 2011, 2011: 280-284.PubMedGoogle Scholar
- Burt RK, Shah SJ, Dill K, Grant T, Gheorghiade M, Schroeder J, Craig R, Hirano I, Marshall K, Ruderman E, Jovanovic B, Milanetti F, Jain S, Boyce K, Morgan A, Carr J, Barr W: Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomised phase 2 trial. Lancet. 2011, 378: 498-506.PubMedGoogle Scholar
- Dhaun N, MacIntyre IM, Bellamy CO, Kluth DC: Endothelin receptor antagonism and renin inhibition as treatment options for scleroderma kidney. Am J Kidney Dis. 2009, 54: 726-731.PubMedGoogle Scholar
- Sfikakis PP, Papamichael C, Stamatelopoulos KS, Tousoulis D, Fragiadaki KG, Katsichti P, Stefanadis C, Mavrikakis M: Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis. Arthritis Rheum. 2007, 56: 1985-1993.PubMedGoogle Scholar
- Vadacca M, Margiotta D, Sambataro D, Buzzulini F, Lo Vullo M, Rigon A, Afeltra A: BAFF/APRIL pathway in Sjogren syndrome and systemic lupus erythematosus: relationship with chronic inflammation and disease activity. Reumatismo. 2010, 62: 259-265.PubMedGoogle Scholar
- Weidenbusch M, Rommele C, Schrottle A, Anders HJ: Beyond the LUNAR trial. Efficacy of rituximab in refractory lupus nephritis. Nephrol Dial Transplant. 2013, 28: 106-111.PubMedGoogle Scholar
- Merrill J, Buyon J, Furie R, Latinis K, Gordon C, Hsieh HJ, Brunetta P: Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER). Lupus. 2011, 20: 709-716.PubMedGoogle Scholar
- Vital EM, Dass S, Buch MH, Henshaw K, Pease CT, Martin MF, Ponchel F, Rawstron AC, Emery P: B cell biomarkers of rituximab responses in systemic lupus erythematosus. Arthritis Rheum. 2011, 63: 3038-3047.PubMedGoogle Scholar
- Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, Wanner C, Krane V, Cass A, Craig J, Neal B, Jiang L, Hooi LS, Levin A, Agodoa L, Gaziano M, Kasiske B, Walker R, Massy ZA, Feldt-Rasmussen B, Krairittichai U, Ophascharoensuk V, Fellstrom B, Holdaas H, Tesar V, Wiecek A, Grobbee D, de Zeeuw D, Gronhagen-Riska C, Dasgupta T: The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (study of heart and renal protection): a randomised placebo-controlled trial. Lancet. 2011, 377: 2181-2192.PubMedPubMed CentralGoogle Scholar
- Malaviya AP, Hall FC: Targeting CVD risk in chronic connective tissue disease. Practitioner. 2012, 256: 21-26.PubMedGoogle Scholar
- Marengo M, Waimann C, de Achaval S, Zhang H, Garcia Gonzalez A, Richardson MN, Reveille JD, Suarez-Almazor ME: Measuring therapeutic adherence in systemic lupus erythematosus with electronic monitoring. Lupus. 2012, 21: 1158-1165.PubMedGoogle Scholar
- Klareskog L, Padyukov L, Alfredsson L: Smoking as a trigger for inflammatory rheumatic diseases. Curr Opin Rheumatol. 2007, 19: 49-54.PubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/11/95/prepub
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