The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans
© Heppner et al; licensee BioMed Central Ltd. 2009
Received: 06 November 2008
Accepted: 09 January 2009
Published: 09 January 2009
There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity and mortality, as a correlate of long-term health risk in PTSD.
We analyzed clinical data from 253 male and female veterans, corresponding to five factors linked to metabolic syndrome (systolic and diastolic blood pressure, waist-to-hip ratio and fasting measures of high-density lipoprotein (HDL) cholesterol, serum triglycerides and plasma glucose concentration). Clinical cut-offs were defined for each biological parameter based on recommendations from the World Health Organization and the National Cholesterol Education Program. Controlling for relevant variables including sociodemographic variables, alcohol/substance/nicotine use and depression, we examined the impact of PTSD on metabolic syndrome using a logistic regression model.
Two-fifths (40%) of the sample met criteria for metabolic syndrome. Of those with PTSD (n = 139), 43% met criteria for metabolic syndrome. The model predicted metabolic syndrome well (-2 log likelihood = 316.650, chi-squared = 23.731, p = 0.005). Veterans with higher severity of PTSD were more likely to meet diagnostic criteria for metabolic syndrome (Wald = 4.76, p = 0.03).
These findings provide preliminary evidence linking higher severity of PTSD with risk factors for diminished health and increased morbidity, as represented by metabolic syndrome.
Several lines of research suggest that stress and post-stress adaptational responses are related to long-term health outcomes. Studies of survivors of disasters, veterans and prisoners of war, and others exposed to severe trauma, suggest higher rates of physical morbidity and mortality and increased healthcare utilization related to lifetime prevalence of trauma [1–7]. There is accumulating evidence from epidemiological studies that chronic posttraumatic stress disorder (PTSD) may moderate the link between trauma and secondary negative health outcomes such as cardiovascular, metabolic and autoimmune conditions [4–9]. Furthermore, Chrousos and colleagues have linked maladaptive neuro-endocrine-immune responses to psychiatric, endocrine and/or autoimmune disease or vulnerability to such diseases [10, 11]. Evidence for neuro-endocrine-immune abnormalities associated with PTSD, also provides a biological rationale for downstream health effects observed in the epidemiological studies [12–16].
Metabolic syndrome or syndrome × is composed of a cluster of clinical signs including dyslipidemia, hyperglycemia (insulin resistance), central obesity and hypertension . Recent research on the impact of stress on health has focused on metabolic syndrome as a possible consequence of pathophysiological adaptations to chronic stress . Brunner and colleagues studied metabolic syndrome status in the Whitehall II cohort and found markers associated with increased stress-related neuroendocrine and autonomic activation such as lowered heart rate variability, increased cortisol output and higher levels of IL-6, C-reactive protein and blood viscosity among cases with metabolic syndrome as compared with those who did not meet diagnostic criteria . Additional analyses of prospective data from the Whitehall cohort also suggest a dose-response relationship between stress and the presence of metabolic syndrome such that participants with chronic exposure to work stress were found to be more than twice as likely to have the syndrome after controlling for age, sex and health behaviors . In a recent study of 2189 Gulf War I veterans, those with chronic multisymptom illness, as defined by presence of fatigue, musculoskeletal pain, mood or cognitive abnormalities for at least 6 months, had significantly higher prevalence of metabolic syndrome .
While there is a lack of consensus in specific clinical definitions of metabolic syndrome, prospective studies have shown it to be an important predictor of physical morbidity and mortality [22–25]. For example, in a comparison of four definitions based on guidelines from the World Health Organization (WHO) and the National Cholesterol Education Program (NCEP), metabolic syndrome was found to predict incidence and prevalence of diabetes mellitus in a prospective study . Similarly, in a sample of 5128 men, metabolic syndrome was found to be a significant predictor of the development of cardiovascular disease (CVD) and diabetes mellitus .
In this study, we examined physical measures and laboratory values in a sample of veterans, to examine the association between PTSD severity and the presence of metabolic syndrome. We hypothesized that greater severity of PTSD would be associated with a higher likelihood of metabolic syndrome.
Comprehensive medical and mental health examinations were completed by 355 veterans entering Gulf War Screening and PTSD Programs at the Cincinnati Veterans Affairs, of whom 341 signed informed consents permitting use of their data for a health-related study. The study was conducted in accordance with the Helsinki Declaration, and was approved by the Institutional Review Board of the University of Cincinnati Medical Center and the Research Committee of the Cincinnati Veterans Affairs Medical Center (Protocol #00-03-07-01-E; "Health-related quality of life in post-deployment veterans").
Of the 341 veterans with signed consent, we excluded 68 veterans who had missing data from at least one of the variables of interest, 18 veterans whose laboratory values were greater than 3 standard deviations (SD) from the group mean, and 2 veterans who had both missing data and laboratory values greater than 3 SD from the mean. Cases with extreme laboratory values were excluded to allow for a more conservative analysis of quantitative physiological burden. These exclusions yielded a remaining sample size of 253 veterans.
Veterans provided sociodemographic information including years of education, military service and deployment history via written questionnaires.
PTSD severity was measured using the Clinician Administered PTSD Scale (CAPS), which ranges in scores from 0 to 136 (see ). A score of 65 or above on the CAPS has been shown to be optimally specific and efficient in predicting PTSD and was used, along with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria, to identify veterans with PTSD . Lifetime and current diagnoses of major depressive disorder (MDD), substance, alcohol and nicotine abuse or dependence were determined using a structured diagnostic interview [28, 29].
Physical examinations including waist-to-hip ratio (WHR), blood pressure and laboratory tests (12-hour fasting lipids, glucose) were conducted on each veteran. Phlebotomy was scheduled between 7 and 9 AM. All samples were assayed within the hospital clinical laboratory.
Clinically determined criterion scores for metabolic syndrome
≥ 150 mg dl-1
< 35 mg dl-1
≥ 130 mm/Hg
≥ 85 mm/Hg
Plasma glucose concentration
≥ 110 mg dl-1
We examined the relationship between PTSD and metabolic syndrome using a logistic regression model. In addition, we conducted a series of independent-sample t-tests to determine whether those with PTSD differed on these five criteria from those without PTSD. Statistical analyses were conducted using SPSS (Statistical Package for Social Sciences) version 15.0. Metabolic syndrome was regressed on the following predictors: PTSD severity (CAPS), age, gender, race (white, black/other), years of education, history of substance abuse/dependence, history of alcohol abuse/dependence, nicotine abuse/dependence (lifetime) and current or past diagnosis of MDD. All predictors were simultaneously entered into the regression model as a single block in order to determine whether PTSD severity was a valid predictor of metabolic syndrome status, while controlling for all other demographic, behavioral and psychiatric variables.
Sociodemographic, medical and psychiatric characteristics of veterans (N = 253)
Number (percentage) of all veterans
Branch of service
World War II
Gulf War I
Medical and psychiatric diagnoses
At least moderate severity
Nicotine abuse/dependence (lifetime)
Substance abuse/dependence (past)
Alcohol abuse/dependence (past)
Co-morbid PTSD and MDD
Co-morbid PTSD and lifetime nicotine abuse/dependence
Co-morbid PTSD and past substance abuse/dependence
Co-morbid PTSD and past alcohol abuse/dependence
Metabolic syndrome (prevalence)
PTSD only and metabolic syndrome
MDD only and metabolic syndrome
PTSD, MDD and metabolic syndrome
Age (mean ± standard deviation (SD)) = 51.5 ± 9.0 years
Length of education (mean ± SD) = 12.9 ± 2.4 years
CAPS score (mean ± SD) = 62.8 ± 29.4 years.
Physical measures and laboratory values used to determine metabolic syndrome
All Veterans (N= 253)
With PTSD (N= 139)
Without PTSD (N= 114)
189.5 ± 141.8
194.6 ± 154.7
183.3 ± 124.7
42.7 ± 11.3
42.5 ± 10.6
43.0 ± 12.0
130.8 ± 15.3
132.2 ± 16.0
129.1 ± 14.4
81.7 ± 10.0
82.9 ± 9.9
80.2 ± 10.0
0.97 ± 0.07
0.98 ± 0.07
0.97 ± 0.06
0.85 ± 0.06
0.87 ± 0.03
0.84 ± 0.06
Plasma glucose concentration
106.4 ± 26.8
105.6 ± 26.3
107.5 ± 27.5
PTSD and metabolic syndrome
Logistic regression predicting metabolic syndrome score
Years of education
In a sample of 253 male and female veterans, greater severity of PTSD was associated with higher likelihood of metabolic syndrome after controlling for relevant demographic, behavioral and psychiatric factors. This finding aligns with and extends existing research examining metabolic syndrome in populations vulnerable to PTSD. Violanti and colleagues found metabolic syndrome to be three times more likely in police officers with severe PTSD symptoms as compared with police officers in the lowest PTSD severity category , while others have found that that 31–35% of male war veteran samples with combat PTSD evidenced concomitant metabolic syndrome [34, 35]. Of note, the current study utilized the largest sample size to date and the most diverse in terms of gender, given the small but extant presence of women.
The importance of the association between PTSD and metabolic syndrome becomes apparent when one considers the fact that metabolic syndrome has been shown to predict CVD-related morbidity and mortality [23, 25]. Our findings suggest that metabolic syndrome provides a useful framework for assessing and describing the physiologic burden of PTSD and can be used prospectively to evaluate the increased health risk associated with combat exposure and PTSD.
The prevalence of metabolic syndrome in our sample (40%) and specifically among those with PTSD (43%) were slightly higher than rates observed among adults in the general population as reported in the National Health and Nutrition Examination Survey (NHANES) which ranged from 20% to 31% [36–38]. Loucks and colleagues reported mean values from men and women ages 25 years and over on individual metabolic syndrome components also collected in our sample (HDL, serum triglycerides, SBP, DBP, and fasting glucose) . Compared with the women and men surveyed in NHANES, our sample of veterans tended to have higher mean triglycerides (189.5 mg dl-1 versus 132.3 and 164.0 mg dl-1 for women and men, respectively), higher SBP (130.8 mm/Hg versus 122.1 and 123.1 mm/Hg), higher DBP (81.7 mm/Hg versus 71.2 and 74.4 mm/Hg), higher fasting glucose (106.4 mg dl-1 versus 98.8 and 103.4 mg dl-1), and lower HDL (42.7 mg dl-1 versus 55.8 and 45.3 mg dl-1). While our sample appeared to be 'less healthy' based on the pattern of mean values, our participants also tended to be older (mean age of 51.5 years as compared with mean ages of 47.2 and 44.7 years for women and men, respectively, in NHANES).
In spite of the growing attention on the importance and surveillance of metabolic syndrome, it should be noted that there is still considerable controversy regarding its definition and utility. Recent reviews pose questions regarding the need for a consensus in the definition of metabolic syndrome, lack of certainty about the underlying pathophysiological process, whether the syndrome itself conveys more information about health risk than the sum of its individual components, and how different combinations of risk factors should guide clinical management [39–41]. In addition to research examining long-term health risk from PTSD, prospective studies are similarly needed to continue to address these remaining questions about metabolic syndrome.
A closely related concept, allostatic load, represents the cumulative biological burden of exposure to repeated cycles of adaptation to stress . It incorporates the notion of stress, as well as the contribution of genetic, developmental, and lifestyle factors that might underpin the physiologic response to daily life events and traumatic stressors [42–45]. The selected factors that contribute to metabolic syndrome in this study closely approximate the secondary mediators of allostatic load, with the exception of serum triglycerides [46, 47]. Our cross-sectional findings show a relationship between PTSD and metabolic syndrome suggesting that perhaps metabolic syndrome in itself is a useful clinical tool in quantifying the cardiovascular and metabolic impact of PTSD. In comparing those with and without PTSD on individual measures of metabolic syndrome components, we only found significant group differences for DBP, suggesting the utility of considering these measures collectively as the presence or absence of metabolic syndrome. It should be noted, however, that these multiple comparisons were not adjusted according to the Bonferroni principle, thereby potentially inflating Type I error in our analysis. Several studies appear to support the dysregulating effect of PTSD on a number of physiologic systems [12–16, 33–35, 48]. Given this association, future prospective studies examining physical morbidity and mortality related to PTSD should also assess metabolic syndrome to determine whether the pattern of dysregulation represented by metabolic syndrome mediates long-term health risk in PTSD.
Interestingly, we did not find MDD to be a significant and unique predictor of risk for metabolic syndrome, in spite of preliminary findings suggesting increased HPA activity with depression [49–55]. These previous studies, however, focused on depression and did not assess or control for PTSD. Our findings may provide preliminary evidence for a higher relative contribution of PTSD to metabolic syndrome after controlling for MDD.
One limitation of the current study is the under-representation of women and minority groups. While female gender was found to be associated with decreased risk of metabolic syndrome, in spite of the small number of women in the study (7.9%), race did not appear to have unique effects on metabolic syndrome. A more diverse sample may yield important information on whether the relationship between PTSD and metabolic syndrome is robust across different racial/ethnic groups.
Finally, given the cross-sectional design of our study, we cannot fully establish a causal relationship between PTSD and metabolic syndrome. Prospective studies are clearly needed in this area to fully examine the long-term health risk related to PTSD.
This study extends the current knowledge of PTSD and diminished health status by examining metabolic syndrome while controlling for relevant health and psychiatric variables. After controlling for MDD, and alcohol, nicotine and substance abuse or dependence, we found a robust and significant association between PTSD severity and health risk as measured by metabolic syndrome. Further exploration, using prospective studies with assessment of CVD- and metabolic-related conditions, are indicated to determine whether metabolic syndrome can sufficiently account for the higher morbidity and mortality observed among those exposed to trauma or with PTSD.
Clinician Administered PTSD Scale
diastolic blood pressure
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition
major depressive disorder
National Cholesterol Education Program
National Health and Nutrition Examination Survey
posttraumatic stress disorder
systolic blood pressure
Statistical Package for Social Sciences
variance inflation factor
World Health Organization
DGB and RLH are supported by VACO Research funds (VA Merit Review, VA-DOD, MIRECC, HSR&D, and the Office of Environmental Hazards). This work is supported in part by these funds. NA is supported in part by NIH R01AR51524. PSH (1), NA, DGB, RLH, and SEN are also supported by the VA Center of Excellence for Stress and Mental Health. We thank the clinicians at the Veterans Affairs of Cincinnati who participated in the collection of data and Laura Harder who provided assistance with manuscript formatting.
- Krause N, Shaw BA, Cairney J: A descriptive epidemiology of lifetime trauma and the physical health status of older adults. Psychol Aging. 2004, 19: 637-648. 10.1037/0882-79126.96.36.1997.View ArticlePubMedGoogle Scholar
- Boscarino JA: Posttraumatic stress disorder and mortality among U.S. Army veterans 30 years after military service. Ann Epidemiol. 2006, 16: 248-256. 10.1016/j.annepidem.2005.03.009.View ArticlePubMedGoogle Scholar
- Kimerling R, Calhoun KS: Somatic symptoms, social support, and treatment seeking among sexual assault victims. J Consult Clin Psychol. 1994, 62: 333-340. 10.1037/0022-006X.62.2.333.View ArticlePubMedGoogle Scholar
- Pizarro J, Silver RC, Prause J: Physical and mental health costs of traumatic war experiences among Civil War veterans. Arch Gen Psychiatry. 2006, 63: 193-200. 10.1001/archpsyc.63.2.193.View ArticlePubMedPubMed CentralGoogle Scholar
- Vieweg WV, Julius DA, Fernandez A, Tassone DM, Narla SN, Pandurangi AK: Posttraumatic stress disorder in male military veterans with comorbid overweight and obesity: psychotropic, antihypertensive, and metabolic medications. Prim Care Companion J Clin Psychiatry. 2006, 8: 25-31.View ArticlePubMedPubMed CentralGoogle Scholar
- Kang HK, Bullman TA, Taylor JW: Risk of selected cardiovascular diseases and posttraumatic stress disorder among former World War II prisoners of war. Ann Epidemiol. 2006, 16: 381-386. 10.1016/j.annepidem.2005.03.004.View ArticlePubMedGoogle Scholar
- Boscarino JA: Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. Ann N Y Acad Sci. 2004, 1032: 141-153. 10.1196/annals.1314.011.View ArticlePubMedGoogle Scholar
- Maia DB, Marmar CR, Mendlowicz MV, Metzler T, Nobrega A, Peres MC, Coutinho ES, Volchan E, Figueira I: Abnormal serum lipid profile in Brazilian police officers with post-traumatic stress disorder. J Affect Disord. 2008, 107: 259-263. 10.1016/j.jad.2007.08.013.View ArticlePubMedGoogle Scholar
- Vieweg WV, Julius DA, Bates J, Quinn JF, Fernandez A, Hasnain M, Pandurangi AK: Posttraumatic stress disorder as a risk factor for obesity among male military veterans. Acta Psychiatr Scand. 2007, 116: 483-487. 10.1111/j.1600-0447.2007.01071.x.View ArticlePubMedGoogle Scholar
- Chrousos GP: Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann N Y Acad Sci. 1998, 851: 311-335. 10.1111/j.1749-6632.1998.tb09006.x.View ArticlePubMedGoogle Scholar
- Chrousos GP: Stress, chronic inflammation, and emotional and physical well-being: concurrent effects and chronic sequelae. J Allergy Clin Immunol. 2000, 106 (Suppl): S275-S291. 10.1067/mai.2000.110163.View ArticlePubMedGoogle Scholar
- Baker DG, Geracioti TD, Kasckow JW, Zoumakis E, Chrousos GP: Cytokines and PTSD. Cytokines and Mental Health. Edited by: Kronfol Z. 2003, Boston, MA: Kluwer Academic, 301-338.View ArticleGoogle Scholar
- Baker DG, West SA, Nicholson WE, Ekhator NN, Kasckow JW, Hill KK, Bruce AB, Orth DN, Geracioti TD: Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 1999, 156: 585-588.PubMedGoogle Scholar
- Baker DG, Ekhator NN, Kasckow JW, Hill KK, Zoumakis E, Dashevsky BA, Chrousos GP, Geracioti TD: Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation. 2001, 9: 209-217. 10.1159/000049028.View ArticlePubMedGoogle Scholar
- Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS: Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am J Psychiatry. 1997, 154: 624-629.View ArticlePubMedPubMed CentralGoogle Scholar
- Geracioti TD, Baker DG, Ekhator NN, West SA, Hill KK, Bruce AB, Schmidt D, Rounds-Kugler B, Yehuda R, Keck PE, Kasckow JW: CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry. 2001, 158: 1227-1230. 10.1176/appi.ajp.158.8.1227.View ArticlePubMedGoogle Scholar
- Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Spertus JA, Costa F: Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary. Cardiol Rev. 2005, 13: 322-327.PubMedGoogle Scholar
- Chrousos GP: The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int J Obes Relat Metab Disord. 2000, 24 (Suppl 2): S50-S55.View ArticlePubMedGoogle Scholar
- Brunner EJ, Hemingway H, Walker BR, Page M, Clarke P, Juneja M, Shipley MJ, Kumari M, Andrew R, Seckl JR, et al: Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation. 2002, 106: 2659-2665. 10.1161/01.CIR.0000038364.26310.BD.View ArticlePubMedGoogle Scholar
- Chandola T, Brunner E, Marmot M: Chronic stress at work and the metabolic syndrome: prospective study. BMJ. 2006, 332: 521-525. 10.1136/bmj.38693.435301.80.View ArticlePubMedPubMed CentralGoogle Scholar
- Blanchard MS, Eisen SA, Alpern R, Karlinsky J, Toomey R, Reda DJ, Murphy FM, Jackson LW, Kang HK: Chronic multisymptom illness complex in Gulf War I veterans 10 years later. Am J Epidemiol. 2006, 163: 66-75. 10.1093/aje/kwj008.View ArticlePubMedGoogle Scholar
- Pervanidou P, Kanaka-Gantenbein C, Chrousos GP: Assessment of metabolic profile in a clinical setting. Curr Opin Clin Nutr Metab Care. 2006, 9: 589-595.View ArticlePubMedGoogle Scholar
- Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT: The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002, 288: 2709-2716. 10.1001/jama.288.21.2709.View ArticlePubMedGoogle Scholar
- Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA: Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002, 156: 1070-1077. 10.1093/aje/kwf145.View ArticlePubMedGoogle Scholar
- Kohli P, Greenland P: Role of the metabolic syndrome in risk assessment for coronary heart disease. JAMA. 2006, 295: 819-821. 10.1001/jama.295.7.819.View ArticlePubMedGoogle Scholar
- Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM: The development of a Clinician-Administered PTSD Scale. J Trauma Stress. 1995, 8: 75-90.View ArticlePubMedGoogle Scholar
- Weathers FW, Ruscio AM, Keane TM: Psychometric properties of nine scoring rules for the Clinician-Administered Posttraumatic Stress Disorder Scale. Psychol Assess. 1999, 11: 124-133. 10.1037/1040-35188.8.131.52.View ArticleGoogle Scholar
- First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-1). 1997, Washington, DC: American Psychiatric PressGoogle Scholar
- Smeets RMW, Dingemans PMAJ: Composite Internation Diagnostic Interview (CIDI)-Version 1.1. 1993, Amsterdam: World Health OrganizationGoogle Scholar
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP). JAMA. 2001, 285: 2486-2497. 10.1001/jama.285.19.2486.View ArticleGoogle Scholar
- Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998, 15: 539-553. 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.View ArticlePubMedGoogle Scholar
- World Health Organization: Definition, Diagnosis, and Classification of Diabetes Mellitus and its Complications, Part I. Diagnosis and Classification of Diabetes Mellitus. 1999, Geneva: World Health Organization; [Technical Report Series, No. 99.92.]Google Scholar
- Violanti JM, Fekedulegn D, Hartley TA, Andrew ME, Charles LE, Mnatsakanova A, Burchfiel CM: Police trauma and cardiovascular disease: association between PTSD symptoms and metabolic syndrome. Int J Emerg Ment Health. 2006, 8: 227-237.PubMedGoogle Scholar
- Jakovljevic M, Saric M, Nad S, Topic R, Vuksan-Cusa B: Metabolic syndrome, somatic and psychiatric comorbidity in war veterans with post-traumatic stress disorder: preliminary findings. Psychiatr Danub. 2006, 18: 169-176.PubMedGoogle Scholar
- Babic D, Jakovljevic M, Martinac M, Saric M, Topic R, Maslov B: Metabolic syndrome and combat post-traumatic stress disorder intensity: preliminary findings. Psychiatr Danub. 2007, 19: 68-75.PubMedGoogle Scholar
- Loucks EB, Magnusson KT, Cook S, Rehkopf DH, Ford ES, Berkman LF: Socioeconomic position and the metabolic syndrome in early, middle, and late life: evidence from NHANES 1999–2002. Ann Epidemiol. 2007, 17: 782-790. 10.1016/j.annepidem.2007.05.003.View ArticlePubMedGoogle Scholar
- Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB: The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med. 2003, 163: 427-436. 10.1001/archinte.163.4.427.View ArticlePubMedPubMed CentralGoogle Scholar
- Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002, 287: 356-359. 10.1001/jama.287.3.356.View ArticlePubMedGoogle Scholar
- de Zeeuw D, Bakker SJ: Does the metabolic syndrome add to the diagnosis and treatment of cardiovascular disease?. Nat Clin Pract Cardiovasc Med. 2008, 5 (Suppl 1): S10-S14. 10.1038/ncpcardio1271.View ArticlePubMedGoogle Scholar
- Brietzke SA: Controversy in diagnosis and management of the metabolic syndrome. Med Clin North Am. 2007, 91: 1041-1061. 10.1016/j.mcna.2007.06.005. vii-viiiView ArticlePubMedGoogle Scholar
- Kahn R, Buse J, Ferrannini E, Stern M: The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2005, 28: 2289-2304. 10.2337/diacare.28.9.2289.View ArticlePubMedGoogle Scholar
- McEwen BS, Stellar E: Stress and the individual. Mechanisms leading to disease. Arch Intern Med. 1993, 153: 2093-2101. 10.1001/archinte.153.18.2093.View ArticlePubMedGoogle Scholar
- McEwen BS: The neurobiology and neuroendocrinology of stress. Implications for post-traumatic stress disorder from a basic science perspective. Psychiatr Clin North Am. 2002, 25: 469-494. 10.1016/S0193-953X(01)00009-0. ixView ArticlePubMedGoogle Scholar
- McEwen BS: Protective and damaging effects of stress mediators. N Engl J Med. 1998, 338: 171-179. 10.1056/NEJM199801153380307.View ArticlePubMedGoogle Scholar
- McEwen BS: Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology. 2000, 22: 108-124. 10.1016/S0893-133X(99)00129-3.View ArticlePubMedGoogle Scholar
- Seeman TE, McEwen BS, Rowe JW, Singer BH: Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proc Natl Acad Sci USA. 2001, 98: 4770-4775. 10.1073/pnas.081072698.View ArticlePubMedPubMed CentralGoogle Scholar
- Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS: Price of adaptation – allostatic load and its health consequences. MacArthur studies of successful aging. Arch Intern Med. 1997, 157: 2259-2268. 10.1001/archinte.157.19.2259.View ArticlePubMedGoogle Scholar
- Glover DA, Stuber M, Poland RE: Allostatic load in women with and without PTSD symptoms. Psychiatry. 2006, 69: 191-203.View ArticlePubMedPubMed CentralGoogle Scholar
- Heiskanen TH, Niskanen LK, Hintikka JJ, Koivumaa-Honkanen HT, Honkalampi KM, Haatainen KM, Viinamaki HT: Metabolic syndrome and depression: a cross-sectional analysis. J Clin Psychiatry. 2006, 67: 1422-1427.View ArticlePubMedGoogle Scholar
- Sachar EJ, Hellman L, Fukushima DK, Gallagher TF: Cortisol production in depressive illness. A clinical and biochemical clarification. Arch Gen Psychiatry. 1970, 23: 289-298.View ArticlePubMedGoogle Scholar
- Deuschle M, Blum WF, Strasburger CJ, Schweiger U, Weber B, Korner A, Standhardt H, Gotthardt U, Schmider J, Pflaum CD, et al: Insulin-like growth factor-I (IGF-I) plasma concentrations are increased in depressed patients. Psychoneuroendocrinology. 1997, 22: 493-503. 10.1016/S0306-4530(97)00046-2.View ArticlePubMedGoogle Scholar
- Deuschle M, Weber B, Colla M, Depner M, Heuser I: Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation study. Stress. 1998, 2: 281-287.View ArticlePubMedGoogle Scholar
- Carroll BJ, Martin FI, Davies B: Resistance to suppression by dexamethasone of plasma 11-O.H.C.S. levels in severe depressive illness. Br Med J. 1968, 3: 285-287.View ArticlePubMedPubMed CentralGoogle Scholar
- Weber B, Lewicka S, Deuschle M, Colla M, Heuser I: Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology. 2000, 25: 765-771. 10.1016/S0306-4530(00)00023-8.View ArticlePubMedGoogle Scholar
- Young EA, Haskett RF, Grunhaus L, Pande A, Weinberg VM, Watson SJ, Akil H: Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients. Arch Gen Psychiatry. 1994, 51: 701-707.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/7/1/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.