MRI plaque imaging and its role in population-based studies
© Yuan and Berry; licensee BioMed Central Ltd. 2010
Received: 11 October 2010
Accepted: 30 November 2010
Published: 30 November 2010
Noninvasive direct vessel wall (plaque) imaging may provide a good opportunity to study unique aspects of atherosclerotic lesions in different populations. The article published by Esposito et al. provides new insights into our understanding of diabetic atherosclerotic vascular disease by using direct plaque imaging techniques. The findings from this article call for attention to more in vivo imaging to understand the nature of high-risk atherosclerosis, especially in prospective studies in diabetic patients.
See research article: http://www.biomedcentral.com/1471-2342/10/27/abstract
In an article published this month in BMC Medical Imaging, Esposito et al.  provide an important contribution to our understanding of diabetic atherosclerotic vascular disease by applying direct atherosclerotic plaque imaging by magnetic resonance imaging (MRI) to a large group of patients with and without diabetes. In this study, the authors observed an association between diabetes and high-risk carotid plaque characteristics. The authors also observed that carotid plaques may be more in danger of rupturing during endarterectomy than plaques of nondiabetic patients, leading to a greater propensity for distal embolization into the cerebral vasculature.
The effect of diabetes on the atherosclerotic process has been well studied in the past, with multiple studies demonstrating marked increases in the presence of subclinical atherosclerosis across all multiple vascular beds in diabetic patients [2–5]. However, most conventional imaging modalities such as coronary artery calcium and carotid intimal media thickness (IMT) provide quantitative measures of atherosclerosis with limited insight into well-established complexities of the atherosclerotic process, such as the formation of complex, high-risk plaques .
More recently, novel MRI-based techniques have been established which can identify high-risk carotid plaques through the detection of major tissue components such as lipid-rich necrotic core, intraplaque hemorrhage and calcium [7–9]. These techniques represent a reliable measure of these plaque features as compared to histology and have been shown to represent significant determinants of both clinical (i.e., stroke)  and subclinical (i.e., plaque progression) events . Although these techniques have been well studied in clinical populations, there has been relatively little application of these imaging techniques to diabetic atherosclerotic disease in particular. Therefore, the findings by Esposito and colleagues  represent an important contribution to our understanding of the topic, suggesting that carotid atherosclerosis in diabetic patients is qualitatively distinct.
There are mechanistic observations to suggest the unique characteristics of diabetic atherosclerosis [12–14]. For example, high levels of circulating glucose have been associated with a decrease in nitric oxide availability in the endothelium, thereby translating into atherosclerotic plaque formation . Additional observations have suggested that an increased formation of reactive oxygen species in diabetic patients leads to downstream changes in the formation of inflammatory proteins . Thus, there is biologic plausibility to the argument that diabetic atherosclerosis might in fact be qualitatively different from nondiabetic atherosclerosis.
Some prior studies , but not all , have observed significant differences in the characteristics of atherosclerotic plaque among individuals with diabetes as compared to individuals without diabetes. For example, in a study of 270 autopsy cases, the presence of diabetes was associated with larger necrotic cores, a greater burden of inflammatory infiltrate and a higher prevalence of plaque rupture . However, the presence of diabetes was also associated with marked differences in the overall quantitative burden of atherosclerosis, suggesting the importance of both quantitative and qualitative differences in diabetic atherosclerotic disease.
Prior studies in the carotid MRI literature also observed the strong correlation between the quantitative burden of atherosclerosis and high-risk plaque features such as lipid-rich necrotic core and intraplaque hemorrhage. For example, in the ARIC Carotid MRI study , the prevalence of lipid-rich necrotic core was relatively common among participants with a carotid wall thickness of ≥1.5 mm (42% prevalence), in contrast to those participants with a wall thickness of <1.5 mm (0.6% prevalence). Similar findings were observed in a separate study demonstrating the importance of plaque burden in the development of intraplaque hemorrhage .
Thus, the strong correlation between plaque burden and high-risk plaque characteristics observed in other studies is important to consider in evaluating the current study by Esposito and colleagues . Although the presence of diabetes was associated with a higher prevalence of high-risk plaque characteristics, the authors provided no information on the overall plaque burden between these two groups (i.e., maximum wall thickness). Without these data, our ability to interpret these findings is limited.
Finally, the Esposito et al.  study also observed an association between diabetes and the prevalence of distal embolization in the cerebral vasculature after carotid endarterectomy, suggesting the hypothesis that the presence of diabetes might have clinical implications for the treatment of carotid disease. Several cautionary points should be noted in the interpretation of these results. First, diabetes was significantly associated with a symptomatic presentation of carotid artery disease (39% vs. 22.5%; P = 0.02). Although the authors did adjust for the presence of symptoms in their analyses, the small number of patients undergoing surgery (N = 72) results in a point estimate with wide confidence intervals which should be interpreted with caution. Second, the authors do not include age as a covariate in these analyses. Because we are not given the association between age and diabetes among those referred for surgery, the relative importance of age and diabetes in influencing these findings cannot be adequately assessed.
In summary, because direct plaque imaging by MRI can characterize both lesion size and composition, this technique represents a unique opportunity to broaden our understanding of atherosclerotic vascular disease in different clinical populations (i.e., diabetes). Such studies are not only safe and feasible  but also can be extended into prospective study designs which are critically needed to improve our understanding of atherosclerosis progression and the development of high-risk lesions.
- Esposito L, Saam T, Heider P, Bockelbrink A, Pelisek J, Sepp D, Feuer R, Winkler C, Liebig T, Holzer K, Pauly O, Sadikovic S, Hemmer B, Poppert H: MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis. BMC Med Imaging. 2010, 10: 27-10.1186/1471-2342-10-27.View ArticlePubMedPubMed CentralGoogle Scholar
- Meijer WT, Hoes AW, Rutgers D, Bots ML, Hofman A, Grobbee DE: Peripheral arterial disease in the elderly: The Rotterdam Study. Arterioscler Thromb Vasc Biol. 1998, 18: 185-192.View ArticlePubMedGoogle Scholar
- Beckman JA, Creager MA, Libby P: Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002, 287: 2570-2581. 10.1001/jama.287.19.2570.View ArticlePubMedGoogle Scholar
- Hiatt WR, Hoag S, Hamman RF: Effect of diagnostic criteria on the prevalence of peripheral arterial disease: the San Luis Valley Diabetes Study. Circulation. 1995, 91: 1472-1479.View ArticlePubMedGoogle Scholar
- Fabris F, Zanocchi M, Bo M, Fonte G, Poli L, Bergoglio I, Ferrario E, Pernigotti L: Carotid plaque, aging, and risk factors: a study of 457 subjects. Stroke. 1994, 25: 1133-1140.View ArticlePubMedGoogle Scholar
- Yuan C, Kerwin WS, Yarnykh VL, Cai J, Saam T, Chu B, Takaya N, Ferguson MS, Underhill H, Xu D, Liu F, Hatsukami TS: MRI of atherosclerosis in clinical trials. NMR Biomed. 2006, 19: 636-654. 10.1002/nbm.1065.View ArticlePubMedGoogle Scholar
- Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C: Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation. 2002, 106: 1368-1373. 10.1161/01.CIR.0000028591.44554.F9.View ArticlePubMedGoogle Scholar
- Cai J, Hatsukami TS, Ferguson MS, Kerwin WS, Saam T, Chu B, Takaya N, Polissar NL, Yuan C: In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology. Circulation. 2005, 112: 3437-3444. 10.1161/CIRCULATIONAHA.104.528174.View ArticlePubMedGoogle Scholar
- Saam T, Ferguson MS, Yarnykh VL, Takaya N, Xu D, Polissar NL, Hatsukami TS, Yuan C: Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol. 2005, 25: 234-239. 10.1161/01.ATV.0000155965.54679.79.View ArticlePubMedGoogle Scholar
- Takaya N, Yuan C, Chu B, Saam T, Underhill H, Cai J, Tran N, Polissar NL, Isaac C, Ferguson MS, Garden GA, Cramer SC, Maravilla KR, Hashimoto B, Hatsukami TS: Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI: initial results. Stroke. 2006, 37: 818-823. 10.1161/01.STR.0000204638.91099.91.View ArticlePubMedGoogle Scholar
- Takaya N, Yuan C, Chu B, Saam T, Polissar NL, Jarvik GP, Isaac C, McDonough J, Natiello C, Small R, Ferguson MS, Hatsukami TS: Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation. 2005, 111: 2768-2775. 10.1161/CIRCULATIONAHA.104.504167.View ArticlePubMedGoogle Scholar
- Luscher TF, Creager MA, Beckman JA, Cosentino F: Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II. Circulation. 2003, 108: 1655-1661. 10.1161/01.CIR.0000089189.70578.E2.View ArticlePubMedGoogle Scholar
- Creager MA, Luscher TF, Cosentino F, Beckman JA: Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Circulation. 2003, 108: 1527-1532. 10.1161/01.CIR.0000091257.27563.32.View ArticlePubMedGoogle Scholar
- Cipollone F, Iezzi A, Fazia M, Zucchelli M, Pini B, Cuccurullo C, De Cesare D, De Blasis G, Muraro R, Bei R, Chiarelli F, Schmidt AM, Cuccurullo F, Mezzetti A: The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control. Circulation. 2003, 108: 1070-1077. 10.1161/01.CIR.0000086014.80477.0D.View ArticlePubMedGoogle Scholar
- Cosentino F, Hishikawa K, Katusic ZS, Luscher TF: High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation. 1997, 96: 25-28.View ArticlePubMedGoogle Scholar
- Luscher TF, Steffel J: Sweet and sour: unraveling diabetic vascular disease. Circ Res. 2008, 102: 9-11. 10.1161/01.RES.0000303937.73170.31.View ArticlePubMedGoogle Scholar
- Burke AP, Kolodgie FD, Zieske A, Fowler DR, Weber DK, Varghese PJ, Farb A, Virmani R: Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study. Arterioscler Thromb Vasc Biol. 2004, 24: 1266-1271. 10.1161/01.ATV.0000131783.74034.97.View ArticlePubMedGoogle Scholar
- Wasserman BA, Sharrett AR, Lai S, Gomes AS, Cushman M, Folsom AR, Bild DE, Kronmal RA, Sinha S, Bluemke DA: Risk factor associations with the presence of a lipid core in carotid plaque of asymptomatic individuals using high-resolution MRI: the multi-ethnic study of atherosclerosis (MESA). Stroke. 2008, 39: 329-335. 10.1161/STROKEAHA.107.498634.View ArticlePubMedGoogle Scholar
- Wagenknecht L, Wasserman B, Chambless L, Coresh J, Folsom A, Mosley T, Ballantyne C, Sharrett R, Boerwinkle E: Correlates of carotid plaque presence and composition as measured by MRI: the Atherosclerosis Risk in Communities Study. Circ Cardiovasc Imaging. 2009, 2: 314-322. 10.1161/CIRCIMAGING.108.823922.View ArticlePubMedPubMed CentralGoogle Scholar
- Underhill HR, Yuan C, Yarnykh VL, Chu B, Oikawa M, Dong L, Polissar NL, Garden GA, Cramer SC, Hatsukami TS: Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis. AJNR Am J Neuroradiol. 2010, 31: 487-493. 10.3174/ajnr.A1842.View ArticlePubMedGoogle Scholar
- Balu N, Chu B, Hatsukami TS, Yuan C, Yarnykh VL: Comparison between 2D and 3D high-resolution black-blood techniques for carotid artery wall imaging in clinically significant atherosclerosis. J Magn Reson Imaging. 2008, 27: 918-924. 10.1002/jmri.21282.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/8/78/prepub