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A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

  • Michael T White1Email author,
  • Philip Bejon2, 3,
  • Ally Olotu2,
  • Jamie T Griffin1,
  • Kalifa Bojang4,
  • John Lusingu5,
  • Nahya Salim6,
  • Salim Abdulla6,
  • Nekoye Otsyula7,
  • Selidji T Agnandji8, 9,
  • Bertrand Lell8, 9,
  • Kwaku Poku Asante10,
  • Seth Owusu-Agyei10,
  • Emmanuel Mahama10,
  • Tsiri Agbenyega11,
  • Daniel Ansong11,
  • Jahit Sacarlal12, 13,
  • John J Aponte12, 14 and
  • Azra C Ghani1
BMC Medicine201412:117

DOI: 10.1186/s12916-014-0117-2

Received: 14 March 2014

Accepted: 19 June 2014

Published: 10 July 2014

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
14 Mar 2014 Submitted Original manuscript
31 Mar 2014 Reviewed Reviewer Report - Denise Doolan
9 Apr 2014 Reviewed Reviewer Report - James Beeson
17 May 2014 Author responded Author comments - Michael White
Resubmission - Version 2
17 May 2014 Submitted Manuscript version 2
27 May 2014 Reviewed Reviewer Report - Denise Doolan
4 Jun 2014 Reviewed Reviewer Report - M Elizabeth Halloran
12 Jun 2014 Reviewed Reviewer Report - James Beeson
Resubmission - Version 3
Submitted Manuscript version 3
16 Jun 2014 Author responded Author comments - Michael White
Resubmission - Version 4
16 Jun 2014 Submitted Manuscript version 4
Publishing
19 Jun 2014 Editorially accepted
10 Jul 2014 Article published 10.1186/s12916-014-0117-2

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London
(2)
KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute
(3)
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford
(4)
Medical Research Council Unit
(5)
National Institute for Medical Research, Tanga Centre
(6)
Ifakara Health Institute
(7)
Kenya Medical Research Institute, and US Army Medical Research Unit–Kenya
(8)
Medical Research Unit, Albert Schweitzer Hospital
(9)
Institute of Tropical Medicine, University of Tübingen
(10)
Kintampo Health Research Centre
(11)
School of Medical Sciences
(12)
Centro de Investigação em Saúde de Manhiça
(13)
Faculdade de Medicina, Universidade Eduardo Mondlane
(14)
Barcelona Centre for International Health Research (CRESIB), Universitat de Barcelona

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