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  1. Research article

    How many people will need palliative care in 2040? Past trends, future projections and implications for services

    Current estimates suggest that approximately 75% of people approaching the end-of-life may benefit from palliative care. The growing numbers of older people and increasing prevalence of chronic illness in many...

    S. N. Etkind, A. E. Bone, B. Gomes, N. Lovell, C. J. Evans, I. J. Higginson and F. E. M. Murtagh

    BMC Medicine 2017 15:102

    Published on: 18 May 2017

  2. Research article

    ING3 promotes prostate cancer growth by activating the androgen receptor

    The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth (ING) proteins target ...

    Arash Nabbi, Urszula L. McClurg, Subhash Thalappilly, Amal Almami, Mahsa Mobahat, Tarek A. Bismar, Olivier Binda and Karl T. Riabowol

    BMC Medicine 2017 15:103

    Published on: 16 May 2017

  3. Research article

    Mediation of the effect of malaria in pregnancy on stillbirth and neonatal death in an area of low transmission: observational data analysis

    Malaria in pregnancy is preventable and contributes significantly to the estimated 5.5 million stillbirths and neonatal deaths that occur annually. The contribution of malaria in pregnancy in areas of low tran...

    Kerryn A. Moore, Freya J. I. Fowkes, Jacher Wiladphaingern, Nan San Wai, Moo Kho Paw, Mupawjay Pimanpanarak, Verena I. Carrara, Jathee Raksuansak, Julie A. Simpson, Nicholas J. White, François Nosten and Rose McGready

    BMC Medicine 2017 15:98

    Published on: 10 May 2017

  4. Research article

    Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies

    Whether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown.

    Tiange Wang, Tao Huang, Jae H. Kang, Yan Zheng, Majken K. Jensen, Janey L. Wiggs, Louis R. Pasquale, Charles S. Fuchs, Hannia Campos, Eric B. Rimm, Walter C. Willett, Frank B. Hu and Lu Qi

    BMC Medicine 2017 15:97

    Published on: 9 May 2017

  5. Research article

    Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes

    Pregnant women with epilepsy frequently experience seizures related to pregnancy complications and are often prescribed anti-epileptic drugs (AEDs) to manage their symptoms. However, less is known about the co...

    Areti Angeliki Veroniki, Elise Cogo, Patricia Rios, Sharon E. Straus, Yaron Finkelstein, Ryan Kealey, Emily Reynen, Charlene Soobiah, Kednapa Thavorn, Brian Hutton, Brenda R. Hemmelgarn, Fatemeh Yazdi, Jennifer D’Souza, Heather MacDonald and Andrea C. Tricco

    BMC Medicine 2017 15:95

    Published on: 5 May 2017

  6. Research article

    Expedited Partner Therapy (EPT) increases the frequency of partner notification among MSM in Lima, Peru: a pilot randomized controlled trial

    Expedited Partner Therapy (EPT) has been shown to improve treatment outcomes among heterosexual partners of individuals with curable sexually transmitted infections (STIs). Although the use of EPT with men who...

    Jesse L. Clark, Eddy R. Segura, Catherine E. Oldenburg, Jessica Rios, Silvia M. Montano, Amaya Perez-Brumer, Manuel Villaran, Jorge Sanchez, Thomas J. Coates and Javier R. Lama

    BMC Medicine 2017 15:94

    Published on: 4 May 2017

  7. Correspondence

    Late presentation of chronic viral hepatitis for medical care: a consensus definition

    We present two consensus definitions of advanced and late stage liver disease being used as epidemiological tools. These definitions can be applied to assess the morbidity caused by liver diseases in different...

    Stefan Mauss, Stanislas Pol, Maria Buti, Erika Duffell, Charles Gore, Jeffrey V. Lazarus, Hilje Logtenberg-van der Grient, Jens Lundgren, Antons Mozalevskis, Dorthe Raben, Eberhard Schatz, Stefan Wiktor and Jürgen K. Rockstroh

    BMC Medicine 2017 15:92

    Published on: 3 May 2017

  8. Research article

    Application of real-time global media monitoring and ‘derived questions’ for enhancing communication by regulatory bodies: the case of human papillomavirus vaccines

    The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines A...

    Priya Bahri, Julianna Fogd, Daniel Morales and Xavier Kurz

    BMC Medicine 2017 15:91

    Published on: 2 May 2017

  9. Research article

    Disease management in the treatment of patients with chronic heart failure who have universal access to health care: a randomized controlled trial

    The efficacy of disease management programs in improving the outcome of heart failure patients remains uncertain and may vary across health systems. This study explores whether a countrywide disease management...

    Ofra Kalter-Leibovici, Dov Freimark, Laurence S. Freedman, Galit Kaufman, Arnona Ziv, Havi Murad, Michal Benderly, Barbara G. Silverman, Nurit Friedman, Tali Cukierman-Yaffe, Elad Asher, Avishay Grupper, Dorit Goldman, Miriam Amitai, Shlomi Matetzky, Mordechai Shani…

    BMC Medicine 2017 15:90

    Published on: 1 May 2017

  10. Research article

    Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children

    We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ...

    Emily M. Teshome, Pauline E. A. Andang’o, Victor Osoti, Sofie R. Terwel, Walter Otieno, Ayşe Y. Demir, Andrew M. Prentice and Hans Verhoef

    BMC Medicine 2017 15:89

    Published on: 28 April 2017

  11. Research article

    The relative importance of large problems far away versus small problems closer to home: insights into limiting the spread of antimicrobial resistance in England

    To combat the spread of antimicrobial resistance (AMR), hospitals are advised to screen high-risk patients for carriage of antibiotic-resistant bacteria on admission. This often includes patients previously ad...

    Tjibbe Donker, Katherine L. Henderson, Katie L. Hopkins, Andrew R. Dodgson, Stephanie Thomas, Derrick W. Crook, Tim E. A. Peto, Alan P. Johnson, Neil Woodford, A. Sarah Walker and Julie V. Robotham

    BMC Medicine 2017 15:86

    Published on: 27 April 2017

  12. Research article

    Effects of unconditional cash transfers on the outcome of treatment for severe acute malnutrition (SAM): a cluster-randomised trial in the Democratic Republic of the Congo

    Cash transfer programs (CTPs) aim to strengthen financial security for vulnerable households. This potentially enables improvements in diet, hygiene, health service access and investment in food production or ...

    Emmanuel Grellety, Pélagie Babakazo, Amina Bangana, Gustave Mwamba, Ines Lezama, Noël Marie Zagre and Eric-Alain Ategbo

    BMC Medicine 2017 15:87

    Published on: 26 April 2017

  13. Research article

    Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

    In adulthood, autoimmune diabetes can present as non-insulin-requiring diabetes, termed as ‘latent autoimmune diabetes in adults’ (LADA). In this study, we investigated established type 1 diabetes (T1D) and ty...

    Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, Kenyaita M. Hodge, Vanessa C. Guy, Hakon Hakonarson, Didac Mauricio, Nanette C. Schloot, Knud B. Yderstræde, Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie and Struan F. A. Grant

    BMC Medicine 2017 15:88

    Published on: 25 April 2017

  14. Research article

    Efavirenz-based simplification after successful early lopinavir-boosted-ritonavir-based therapy in HIV-infected children in Burkina Faso and Côte d’Ivoire: the MONOD ANRS 12206 non-inferiority randomised trial

    The 2016 World Health Organization guidelines recommend all children <3 years start antiretroviral therapy (ART) on protease inhibitor-based regimens. But lopinavir/ritonavir (LPV/r) syrup has many challenges ...

    Désiré Lucien Dahourou, Madeleine Amorissani-Folquet, Karen Malateste, Clarisse Amani-Bosse, Malik Coulibaly, Carole Seguin-Devaux, Thomas Toni, Rasmata Ouédraogo, Stéphane Blanche, Caroline Yonaba, François Eboua, Philippe Lepage, Divine Avit, Sylvie Ouédraogo, Philippe Van de Perre, Sylvie N’Gbeche…

    BMC Medicine 2017 15:85

    Published on: 24 April 2017

  15. Research article

    Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis

    The optimal revascularization technique in patients with left main coronary artery disease (CAD) remains controversial. We aimed to compare the long-term performance of percutaneous coronary intervention (PCI)...

    Xin-Lin Zhang, Qing-Qing Zhu, Jing-Jing Yang, Yu-Han Chen, Yang Li, Su-Hui Zhu, Jun Xie, Lian Wang, Li-Na Kang and Biao Xu

    BMC Medicine 2017 15:84

    Published on: 21 April 2017

  16. Research article

    Accuracy of low-density lipoprotein cholesterol estimation at very low levels

    As the approach to low-density lipoprotein cholesterol (LDL-C) lowering becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants closer attention in individualized clinical effi...

    Renato Quispe, Aditya Hendrani, Mohamed B. Elshazly, Erin D. Michos, John W. McEvoy, Michael J. Blaha, Maciej Banach, Krishnaji R. Kulkarni, Peter P. Toth, Josef Coresh, Roger S. Blumenthal, Steven R. Jones and Seth S. Martin

    BMC Medicine 2017 15:83

    Published on: 20 April 2017

  17. Research article

    Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort

    Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment ...

    Isabelle Carrière, Joanna Norton, Amandine Farré, Marilyn Wyart, Christophe Tzourio, Pernelle Noize, Karine Pérès, Annie Fourrier-Réglat, Karen Ritchie and Marie Laure Ancelin

    BMC Medicine 2017 15:81

    Published on: 19 April 2017

  18. Opinion

    The new field of ‘precision psychiatry’

    Precision medicine is a new and important topic in psychiatry. Psychiatry has not yet benefited from the advanced diagnostic and therapeutic technologies that form an integral part of other clinical specialtie...

    Brisa S. Fernandes, Leanne M. Williams, Johann Steiner, Marion Leboyer, André F. Carvalho and Michael Berk

    BMC Medicine 2017 15:80

    Published on: 13 April 2017

  19. Research article

    S100β as a serum marker in endocrine resistant breast cancer

    Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired resistance. Here the potential of S100β as a biomarker and ...

    Sara Charmsaz, Éamon Hughes, Fiona T. Bane, Paul Tibbitts, Marie McIlroy, Christopher Byrne, Sinéad Cocchiglia, Jean McBryan, Bryan T. Hennessy, Róisín M. Dwyer, Michael J. Kerin, Arnold D. Hill and Leonie S. Young

    BMC Medicine 2017 15:79

    Published on: 12 April 2017

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