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  1. Research article

    Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial

    RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole-genome sequencing (WGS) is evaluated within RIF...

    Adam A. Witney, Anna L. E. Bateson, Amina Jindani, Patrick P. J. Phillips, David Coleman, Neil G. Stoker, Philip D. Butcher and Timothy D. McHugh

    BMC Medicine 2017 15:71

    Published on: 29 March 2017

  2. Research article

    The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial

    Among older persons, disability is often precipitated by intervening illnesses and injuries leading to hospitalization. In the Lifestyle Interventions and Independence for Elders (LIFE) Study, a structured mod...

    Thomas M. Gill, Daniel P. Beavers, Jack M. Guralnik, Marco Pahor, Roger A. Fielding, Michelle Hauser, Todd M. Manini, Anthony P. Marsh, Mary M. McDermott, Anne B. Newman, Heather G. Allore and Michael E. Miller

    BMC Medicine 2017 15:65

    Published on: 28 March 2017

  3. Research article

    The association between the day of the week of milestones in the care pathway of patients with hip fracture and 30-day mortality: findings from a prospective national registry – The National Hip Fracture Database of England and Wales

    Recent publications indicate increased mortality in patients admitted to hospital at the weekend, but these findings may be subject to inadequate adjustment for case-mix and the complexities of resource provis...

    Adrian Sayers, Michael R. Whitehouse, James R. Berstock, Karen A. Harding, Michael B. Kelly and Timothy J. Chesser

    BMC Medicine 2017 15:62

    Published on: 27 March 2017

  4. Research article

    Can incontinence be cured? A systematic review of cure rates

    Incontinence constitutes a major health problem affecting millions of people worldwide. The present study aims to assess cure rates from treating urinary (UI) or fecal incontinence (FI) and the number of peopl...

    Rob Riemsma, Suzanne Hagen, Ruth Kirschner-Hermanns, Christine Norton, Helle Wijk, Karl-Erik Andersson, Christopher Chapple, Julian Spinks, Adrian Wagg, Edward Hutt, Kate Misso, Sohan Deshpande, Jos Kleijnen and Ian Milsom

    BMC Medicine 2017 15:63

    Published on: 24 March 2017

  5. Research article

    Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility

    TEX101 is a cell membrane protein exclusively expressed by testicular germ cells and shed into seminal plasma. We previously verified human TEX101 as a biomarker for the differential diagnosis of azoospermia, ...

    Dimitrios Korbakis, Christina Schiza, Davor Brinc, Antoninus Soosaipillai, Theano D. Karakosta, Christine Légaré, Robert Sullivan, Brendan Mullen, Keith Jarvi, Eleftherios P. Diamandis and Andrei P. Drabovich

    BMC Medicine 2017 15:60

    Published on: 23 March 2017

  6. Research article

    Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: a prospective cohort

    We previously reported that one-third of HIV-positive adults requiring medical admission to a South African district hospital had laboratory-confirmed tuberculosis (TB) and that almost two-thirds of cases coul...

    Stephen D. Lawn, Andrew D. Kerkhoff, Rosie Burton, Charlotte Schutz, Andrew Boulle, Monica Vogt, Ankur Gupta-Wright, Mark P. Nicol and Graeme Meintjes

    BMC Medicine 2017 15:67

    Published on: 21 March 2017

  7. Research article

    Are potentially clinically meaningful benefits misinterpreted in cardiovascular randomized trials? A systematic examination of statistical significance, clinical significance, and authors’ conclusions

    While journals and reporting guidelines recommend the presentation of confidence intervals, many authors adhere strictly to statistically significant testing. Our objective was to determine what proportions of...

    G. Michael Allan, Caitlin R. Finley, James McCormack, Vivek Kumar, Simon Kwong, Emelie Braschi, Christina Korownyk, Michael R. Kolber, Adriennne J. Lindblad, Oksana Babenko and Scott Garrison

    BMC Medicine 2017 15:58

    Published on: 20 March 2017

  8. Research article

    Predicting fitness to practise events in international medical graduates who registered as UK doctors via the Professional and Linguistic Assessments Board (PLAB) system: a national cohort study

    International medical graduates working in the UK are more likely to be censured in relation to fitness to practise compared to home graduates. Performance on the General Medical Council’s (GMC’s) Professional...

    Paul A. Tiffin, Lewis W. Paton, Lazaro M. Mwandigha, John C. McLachlan and Jan Illing

    BMC Medicine 2017 15:66

    Published on: 20 March 2017

  9. Research article

    Systematic meta-review of supported self-management for asthma: a healthcare perspective

    Supported self-management has been recommended by asthma guidelines for three decades; improving current suboptimal implementation will require commitment from professionals, patients and healthcare organisati...

    Hilary Pinnock, Hannah L. Parke, Maria Panagioti, Luke Daines, Gemma Pearce, Eleni Epiphaniou, Peter Bower, Aziz Sheikh, Chris J. Griffiths and Stephanie J. C. Taylor

    BMC Medicine 2017 15:64

    Published on: 17 March 2017

  10. Research article

    Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

    Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study we...

    S. Battini, F. Faitot, A. Imperiale, A. E. Cicek, C. Heimburger, G. Averous, P. Bachellier and I. J. Namer

    BMC Medicine 2017 15:56

    Published on: 16 March 2017

  11. Research article

    Potential predatory and legitimate biomedical journals: can you tell the difference? A cross-sectional comparison

    The Internet has transformed scholarly publishing, most notably, by the introduction of open access publishing. Recently, there has been a rise of online journals characterized as ‘predatory’, which actively s...

    Larissa Shamseer, David Moher, Onyi Maduekwe, Lucy Turner, Virginia Barbour, Rebecca Burch, Jocalyn Clark, James Galipeau, Jason Roberts and Beverley J. Shea

    BMC Medicine 2017 15:28

    Published on: 16 March 2017

  12. Minireview

    Elimination of Hepatitis B: Is It a Mission Possible?

    Chronic hepatitis B virus (HBV) infection is a global public health issue. Although the disease cannot be cured effectively, disease management has been improved over the past decade. The introduction of poten...

    Tai-Chung Tseng and Jia-Horng Kao

    BMC Medicine 2017 15:53

    Published on: 15 March 2017

  13. Erratum

    Erratum to: Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review

    Wasifa Zarin, Areti Angeliki Veroniki, Vera Nincic, Afshin Vafaei, Emily Reynen, Sanober S. Motiwala, Jesmin Antony, Shannon M. Sullivan, Patricia Rios, Caitlin Daly, Joycelyne Ewusie, Maria Petropoulou, Adriani Nikolakopoulou, Anna Chaimani, Georgia Salanti, Sharon E. Straus…

    BMC Medicine 2017 15:61

    Published on: 14 March 2017

    The original article was published in BMC Medicine 2017 15:3

  14. Research article

    Cardiovascular risk factors are major determinants of thrombotic risk in patients with the lupus anticoagulant

    Patients with the lupus anticoagulant (LA) are at an increased risk of thrombotic events, which in turn increase the risk of death. Understanding the determinants of thrombotic risk in patients with LA may pav...

    Florian Posch, Johanna Gebhart, Jacob H. Rand, Silvia Koder, Peter Quehenberger, Vittorio Pengo, Cihan Ay and Ingrid Pabinger

    BMC Medicine 2017 15:54

    Published on: 10 March 2017

  15. Research article

    A unique pattern of cortical connectivity characterizes patients with attention deficit disorders: a large electroencephalographic coherence study

    Attentional disorders (ADD) feature decreased attention span, impulsivity, and over-activity interfering with successful lives. Childhood onset ADD frequently persists to adulthood. Etiology may be hereditary ...

    Frank H. Duffy, Aditi Shankardass, Gloria B. McAnulty and Heidelise Als

    BMC Medicine 2017 15:51

    Published on: 9 March 2017

  16. Debate

    Innovative regenerative medicines in the EU: a better future in evidence?

    Despite a steady stream of headlines suggesting they will transform the future of healthcare, high-tech regenerative medicines have, to date, been quite inaccessible to patients, with only eight having been gr...

    Mark S. Corbett, Andrew Webster, Robert Hawkins and Nerys Woolacott

    BMC Medicine 2017 15:49

    Published on: 8 March 2017

  17. Research article

    Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome

    Obesity is an escalating health problem worldwide, and hence the causes underlying its development are of primary importance to public health. There is growing evidence that suboptimal intrauterine environment...

    Xinyi Lin, Ives Yubin Lim, Yonghui Wu, Ai Ling Teh, Li Chen, Izzuddin M. Aris, Shu E. Soh, Mya Thway Tint, Julia L. MacIsaac, Alexander M. Morin, Fabian Yap, Kok Hian Tan, Seang Mei Saw, Michael S. Kobor, Michael J. Meaney, Keith M. Godfrey…

    BMC Medicine 2017 15:50

    Published on: 7 March 2017

  18. Review

    Genetics of vascular dementia – review from the ICVD working group

    Vascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms cou...

    M. Arfan Ikram, Anna Bersano, Raquel Manso-Calderón, Jian-Ping Jia, Helena Schmidt, Lefkos Middleton, Benedetta Nacmias, Saima Siddiqi and Hieab H.H. Adams

    BMC Medicine 2017 15:48

    Published on: 6 March 2017

  19. Research article

    Counting the lives saved by DOTS in India: a model-based approach

    Against the backdrop of renewed efforts to control tuberculosis (TB) worldwide, there is a need for improved methods to estimate the public health impact of TB programmes. Such methods should not only address ...

    Sandip Mandal, Vineet K. Chadha, Ramanan Laxminarayan and Nimalan Arinaminpathy

    BMC Medicine 2017 15:47

    Published on: 3 March 2017

  20. Research article

    The evaluating self-management and educational support in severely obese patients awaiting multidisciplinary bariatric care (EVOLUTION) trial: principal results

    In Canada, demand for multidisciplinary bariatric (obesity) care far outstrips capacity. Consequently, prolonged wait times exist that contribute to substantial health impairments. A supportive, educational, s...

    Raj S. Padwal, Scott Klarenbach, Arya M. Sharma, Miriam Fradette, Susan E. Jelinski, Alun Edwards and Sumit R. Majumdar

    BMC Medicine 2017 15:46

    Published on: 2 March 2017

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