Trial (Reference) | Treatment | No. Patients | Local Failure (%) | Survival Rate at 5 years (%) | ||
---|---|---|---|---|---|---|
 | Preoperative RT | Surgery Delay | Postoperative RT (Delay) |  |  |  |
Pahlman & Glimelius [30] | 5.1 Gy × 5 - | 1 week - | - 60 Gy in 54* (4–6 weeks) | 236 235 | 22% 33% p = 0.012 | 43% 37% p = 0.43 |
RTOG [31] | 0.5 Gy × 1 - | 1 day - | 45–51 Gy* (2–6 weeks) | 175 178 | 32% 32% p = NS | 43% 32% p = NS |
Herrmann et al. [32] | 3.3 Gy × 5 - | 1–2 days - | 41.5 Gy in 48* 59.8 Gy in 56* (6–14 weeks) | 48 46 | 25% 39% p = 0.142 | 49% 37% p = NS |
EORTC [33] | 2.3 × 15 2.3 × 15 + 5-FU | 2 weeks 2 weeks | - - | 121 126 | 15% 15% p = NS | 59% 46% p = 0.06 |
Francois et al. [34] | 3.0 Gy × 13 3.0 Gy × 13 | 2 weeks 6–8 weeks | - - | 99 102 | 9% 9% p = NS | 78%†73%†p = NS |