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Figure 2 | BMC Medicine

Figure 2

From: A tool to facilitate clinical biomarker studies - a tissue dictionary based on the Human Protein Atlas

Figure 2

Images showing examples of H & E-stained tissues, including descriptive text boxes, at three different magnifications. Normal tissue is exemplified by two tissue types. The top overview shows the major components of a normal human colon, followed by higher magnifications revealing the glandular structure of the mucosa with regularly ordered colonic crypts. The finer details of integrated cells and structures are apparent at the highest level of magnification (A). The overview of a normal female breast shows the arrangement of included normal glandular lobules and ducts with magnifications showing a more detailed view of a single lobular unit and details of glandular cells (B). Cancer is exemplified by two cases of breast cancer. A ductal breast carcinoma with low grade malignancy (Elston-Ellis score 4) from a female patient age 68 is displayed at three levels of magnification to demonstrate the overall pattern of tumor growth and the finer details of cancerous glands and details of cancer cells (C). A high grade (Elston-Ellis score 9) ductal breast carcinoma from a female patient age 83 shows the characteristics of infiltrative tumor growth with poorly differentiated glandular structures and severe cellular atypia (D). All figures are original and available at the Human Protein Atlas web portal ( Published with permission from the Human Protein Atlas.

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