Table 4 Altered genes in microarray according to prostatic disease status (overall, OB/OW or lean group)
From: Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
Probe set | Gene Name | Gene Description | Fold Change | P |
|---|---|---|---|---|
Extra Prostatic Cancer versus Benign Prostatic Hyperplasia | Â | Â | ||
All subjects | Â | Â | Â | Â |
7952313 | MIRLET7A2 | microRNA let-7a-2 | 2.00 | 4.26E-06 |
7957540 | MRPL42 | mitochondrial ribosomal protein L42 | 1.63 | 5.49E-06 |
7980891 | TC2N | tandem C2 domains; nuclear | 2.25 | 8.26E-06 |
7915468 | CCDC23 | coiled-coil domain containing 23 | 1.70 | 1.93E-05 |
8002020 | TPPP3 | tubulin polymerization-promoting protein family member 3 | 1.66 | 8.62E-05 |
7980861 | CATSPERB | cation channel; sperm-associated; beta | 1.84 | 1.48E-04 |
7964927 | TSPAN8 | tetraspanin 8 | 1.91 | 2.31E-04 |
8168463 | FGF16 | fibroblast growth factor 16 | 1.67 | 2.93E-04 |
Lean subjects | Â | Â | Â | |
7952313 | MIRLET7A2 | microRNA let-7a-2 | 2.12 | 9.04E-05 |
8024485 | GADD45B | growth arrest and DNA-damage-inducible; beta | -1.56 | 9.47E-04 |
7957540 | MRPL42 | mitochondrial ribosomal protein L42 | 1.60 | 9.86E-04 |
OB/OW subjects | Â | Â | Â | |
7980861 | CATSPERB | cation channel; sperm-associated; beta | 2.50 | 1.91E-06 |
7980891 | TC2N | tandem C2 domains; nuclear | 2.98 | 4.31E-06 |
7908488 | CFHR1 | complement factor H-related 1 | 1.88 | 3.16E-05 |
8078529 | STAC | SH3 and cysteine rich domain | 1.50 | 5.79E-05 |
7902400 | SNORD45B | small nucleolar RNA; C/D box 45B | -5.18 | 1.9E-04 |
7908459 | CFH | complement factor H | 1.70 | 3.0E-04 |
7952313 | MIRLET7A2 | microRNA let-7a-2 | 1.88 | 4.0E-04 |
7957540 | MRPL42 | mitochondrial ribosomal protein L42 | 1.65 | 4.0E-04 |
7958019 | DRAM1 | DNA-damage regulated autophagy modulator 1 | 1.55 | 5.3E-04 |
7969640 | CLDN10 | claudin 10 | 1.59 | 6.3E-04 |
8076586 | SCUBE1 | signal peptide; CUB domain; EGF-like 1 | -1.73 | 7.2E-04 |
8027862 | FFAR2 | free fatty acid receptor 2 | -1.58 | 9.2E-04 |
Organ Confined Prostate Cancer versus Benign Prostatic Hyperplasia | Â | Â | ||
All subjects | Â | Â | Â | Â |
7919349 | RNU1-1 | RNA; U1 small nuclear 1 | -2.18 | 1.50E-07 |
7919576 | RNU1-1 | RNA; U1 small nuclear 1 | -1.96 | 2.47E-07 |
7952313 | MIRLET7A2 | microRNA let-7a-2 | 1.79 | 6.21E-05 |
7980891 | TC2N | tandem C2 domains; nuclear | 1.98 | 6.26E-05 |
7978568 | RNU1-1 | RNA; U1 small nuclear 1 | -1.65 | 9.43E-05 |
7981964 | SNORD116-8 | small nucleolar RNA; C/D box 116-8 | -1.91 | 1.07E-04 |
8004184 | XAF1 | XIAP associated factor 1 | -1.64 | 8.67E-04 |
Lean subjects | Â | Â | Â | |
8001067 | HERC2P4 | hect domain and RLD 2 pseudogene 4 | -1.77 | 1.22E-06 |
7997239 | PDXDC2 | pyridoxal-dependent decarboxylase domain containing 2 | -2.12 | 2.69E-06 |
8000692 | BOLA2 | bolA homolog 2 (E, coli) | -1.52 | 3.41E-06 |
8000651 | SMG1 | SMG1 homolog; phosphatidylinositol 3-kinase-related kinase (C. elegans) | -1.61 | 3.76E-06 |
8019655 | TBC1D3B | TBC1 domain family; member 3B | -1.56 | 1.26E-05 |
7919349 | RNU1-1 | RNA; U1 small nuclear 1 | -2.30 | 2.27E-05 |
7927513 | FAM21C | family with sequence similarity 21; member C | -1.66 | 2.31E-05 |
7993359 | NPIP | nuclear pore complex interacting protein | -1.53 | 4.30E-05 |
8014633 | TBC1D3 | TBC1 domain family; member 3 | -1.55 | 5.53E-05 |
8014437 | TBC1D3G | TBC1 domain family; member 3G | -1.51 | 6.27E-05 |
7994026 | NPIPL3 | nuclear pore complex interacting protein-like 3 | -1.69 | 9.02E-05 |
OB/OW subjects | Â | Â | Â | |
7969640 | CLDN10 | claudin 10 | 2.01 | 7.04E-06 |
7980891 | TC2N | tandem C2 domains; nuclear | 2.31 | 1.10E-04 |
7952313 | MIRLET7A2 | microRNA let-7a-2 | 2.06 | 1.74E-04 |
8021101 | HAUS1 | HAUS augmin-like complex; subunit 1 | 1.61 | 3.10E-04 |
8165698 | MIR1977 | microRNA 1977 | -3.03 | 3.46E-04 |
8060854 | PLCB1 | phospholipase C; beta 1 (phosphoinositide-specific) | 1.53 | 5.95E-04 |
Extra Prostatic Cancer versus Organ Confined Prostate Cancer | Â | Â | ||
All subjects | Â | Â | Â | Â |
7919349 | RNU1-1 | RNA; U1 small nuclear 1 | 1.71 | 1.86E-05 |
7981964 | SNORD116-8 | small nucleolar RNA; C/D box 116-8 | 1.88 | 1.85E-04 |
7940287 | MS4A1 | membrane-spanning 4-domains; subfamily A; member 1 | -2.15 | 2.74E-04 |
Lean subjects | Â | Â | Â | |
8001067 | HERC2P4 | hect domain and RLD 2 pseudogene 4 | 2.06 | 5.14E-08 |
8000692 | BOLA2 | bolA homolog 2 (E, coli) | 1.52 | 3.37E-06 |
7997239 | PDXDC2 | pyridoxal-dependent decarboxylase domain containing 2 | 2.00 | 6.36E-06 |
8000651 | SMG1 | SMG1 homolog; phosphatidylinositol 3-kinase-related kinase (C. elegans) | 1.57 | 6.75E-06 |
7927513 | FAM21C | family with sequence similarity 21; member C | 1.74 | 8.44E-06 |
7993359 | NPIP | nuclear pore complex interacting protein | 1.51 | 5.38E-05 |
7994026 | NPIPL3 | nuclear pore complex interacting protein-like 3 | 1.73 | 5.61E-05 |
8119595 | RPL7L1 | ribosomal protein L7-like 1 | 1.63 | 5.71E-05 |
7990943 | GOLGA6L10 | golgin A6 family-like 10 | 1.55 | 6.08E-05 |
7919349 | RNU1-1 | RNA; U1 small nuclear 1 | 1.93 | 2.25E-04 |
OB/OW subjects | Â | Â | Â | |
7980861 | CATSPERB | cation channel; sperm-associated; beta | 1.78 | 2.92E-04 |
7982006 | SNORD116-29 | small nucleolar RNA; C/D box 116-29 | 1.77 | 5.84E-04 |