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Figure 6 | BMC Medicine

Figure 6

From: Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy

Figure 6

Effect of LeTx on autophagosome formation. A: LC3-II in H9C2 cells treated with different concentrations of lethal toxin (25 to 200 ng/ml); B: LC3-II in H9C2 cells treated with 100 ng/ml lethal toxin for different durations of times (1 to 9 h). Inserts depicting expression LC3-I/II and GAPDH (loading control); C: Representative fluorescent microscopic images of GFP-LC3-II (DAPI's blue staining depicts nucleus; white arrows points autophagosomes); D: Quantitation of number of autophagosome per cell. Mean ± SEM, n = 3 independent cultures, *P <0.05 vs. Control.

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