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Table 3 Association analysis of NPC1 polymorphisms with obesity, BMI, and T2D.

From: Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

Trait Minor allele Whole sample Males Females
   Pvaluea OR (95% CI)b Pvaluea OR (95% CI)b Pvaluea OR (95% CI)b
Obesity        
rs1788799 (C/G) G (Met) >0.5 1.05 (0.87 to 1.18) >0.5 1.02 (0.81 to 1.27) >0.5 1.02 (0.83 to 1.27)
rs1805081 (A/G) G (Arg) >0.5 0.83 (0.78 to 1.25) >0.5 1.06 (0.76 to 1.47) >0.5 0.93 (0.67 to 1.30
BMI   P value a BETA c P value a BETA c P value a BETA c
rs1788799 (C/G) G (Met) 0.462 0.328 >0.5 0.490 >0.5 0.231
rs1805081 (A/G) G (Arg) >0.5 -0.411 >0.5 -0.343 >0.5 -0.450
T2D   P value a OR (95% CI) b P value a OR (95% CI) b P value a OR (95% CI) b
rs1788799 (C/G) G (Met) 0.027 1.24 (1.05 to 1.48) 0.004 1.50 (1.15 to 1.95) >0.5 1.07 (0.85 to 1.36)
rs1805081 (A/G) G (Arg) >0.5 1.06 (0.82 to 1.39) >0.5 1.11 (0.76 to .60) >0.5 1.04 (0.71 to 1.52)
  1. a P values were calculated using logistic or linear regression (as appropriate) with an additive model; Bonferroni-corrected P values are reported; nominally significant P values are in bold; bodds ratio and 95% confidence intervals refer to the minor allele. cregression coefficient. BMI, body mass index; OR, odds ratio; T2D, type 2 diabetes.