Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

Table 4 Association analysis of NPC1 haplotypes with T2D.

Trait	Haplotype _{(rs1805081 -rs1788799, residues)}	Whole sample		Males		Females
		Freq.^a	Pvalue (OR)	Freq.^a	Pvalue (OR)	Freq.^a	Pvalue (OR)
T2D (all)
	GC (Arg-Ile)	0.12	0.451 (1.11)	0.12	0.495 (1.14)	0.12	0.653 (1.09)
	AG (His-Met)	0.41	0.009 (1.26)	0.40	0.0012 (1.54)	0.41	0.545 (1.08)
	AC (His-Ile)	0.47	0.003 (0.77)	0.48	0.0004 (0.63)	0.47	0.425 (0.91)
T2D (obese)
	GC (Arg-Ile)	0.12	0.577 (1.10)	0.12	0.498 (1.20)	0.12	0.780 (1.07)
	AG (His-Met)	0.42	0.230 (1.14)	0.42	0.013 (1.44)	0.41	0.745 (0.95)
	AC (His-Ile)	0.46	0.142 (0.85)	0.46	0.004 (0.60)	0.47	0.813 (1.03)
T2D (non-obese)
	GC (Arg-Ile)	0.11	0.77 (1.07)	0.11	0.957 (1.02)	0.12	0.666 (1.19)
	AG (His-Met)	0.40	0.0125 (1.46)	0.40	0.033 (1.52)	0.41	0.158 (1.40)
	AC (His-Ile)	0.49	0.009 (0.67)	0.49	0.042 (0.69)	0.47	0.088 (0.65)

^ahaplotype frequency. Significant P values are in bold. Freq., frequency; T2D, type 2 diabetes.

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