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Table 4 Association analysis of NPC1 haplotypes with T2D.

From: Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

Trait Haplotype (rs1805081 -rs1788799, residues) Whole sample Males Females
   Freq.a Pvalue (OR) Freq.a Pvalue (OR) Freq.a Pvalue (OR)
T2D (all)        
  GC (Arg-Ile) 0.12 0.451 (1.11) 0.12 0.495 (1.14) 0.12 0.653 (1.09)
  AG (His-Met) 0.41 0.009 (1.26) 0.40 0.0012 (1.54) 0.41 0.545 (1.08)
  AC (His-Ile) 0.47 0.003 (0.77) 0.48 0.0004 (0.63) 0.47 0.425 (0.91)
T2D (obese)        
  GC (Arg-Ile) 0.12 0.577 (1.10) 0.12 0.498 (1.20) 0.12 0.780 (1.07)
  AG (His-Met) 0.42 0.230 (1.14) 0.42 0.013 (1.44) 0.41 0.745 (0.95)
  AC (His-Ile) 0.46 0.142 (0.85) 0.46 0.004 (0.60) 0.47 0.813 (1.03)
T2D (non-obese)        
  GC (Arg-Ile) 0.11 0.77 (1.07) 0.11 0.957 (1.02) 0.12 0.666 (1.19)
  AG (His-Met) 0.40 0.0125 (1.46) 0.40 0.033 (1.52) 0.41 0.158 (1.40)
  AC (His-Ile) 0.49 0.009 (0.67) 0.49 0.042 (0.69) 0.47 0.088 (0.65)
  1. ahaplotype frequency. Significant P values are in bold. Freq., frequency; T2D, type 2 diabetes.