Table 5 Association analysis of NPC1 haplotypes with lipid levels.
Trait | Haplotype (rs1805081-rs1788799, residues) | Whole sample | Males | Females | |||
|---|---|---|---|---|---|---|---|
| Â | Â | BETAa | Pvalue | BETAa | Pvalue | BETAa | Pvalue |
HDL-cholesterol | Â | Â | Â | Â | Â | Â | Â |
| Â | GC (Arg-Ile) | -0.047 | 0.026 | -0.070 | 0.017 | -0.020 | 0.698 |
| Â | AG (His-Met) | -0.013 | 0.32 | 0.004 | 0.803 | -0.0278 | 0.048 |
| Â | AC (His-Ile) | 0.032 | 0.015 | 0.025 | 0.190 | 0.040 | 0.023 |
LDL-cholesterol | Â | Â | Â | Â | Â | Â | Â |
| Â | GC (Arg-Ile) | -0.068 | 0.650 | -0.140 | 0.477 | -0.034 | 0.877 |
| Â | AG (His-Met) | 0.149 | 0.124 | -0.125 | 0.330 | 0.200 | 0.157 |
| Â | AC (His-Ile) | -0.105 | 0.265 | -0.701 | 0.583 | -0.144 | 0.289 |
Total cholesterol | Â | Â | Â | Â | Â | Â | Â |
| Â | GC (Arg-Ile) | -0.011 | 0.408 | 0.003 | 0.872 | -0.028 | 0.166 |
| Â | AG (His-Met) | 0.010 | 0.224 | 0.002 | 0.873 | 0.022 | 0.097 |
| Â | AC (His-Ile) | -0.005 | 0.538 | -0.003 | 0.794 | -0.008 | 0.505 |
Triglycerides | Â | Â | Â | Â | Â | Â | Â |
| Â | GC (Arg-Ile) | 0.045 | 0.101 | 0.104 | 0.003 | -0.0313 | 0.466 |
| Â | AG (His-Met) | 0.024 | 0.173 | -0.014 | 0.563 | 0.071 | 0.009 |
| Â | AC (His-Ile) | -0.041 | 0.018 | -0.031 | 0.181 | -0.052 | 0.046 |