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Table 5 Association analysis of NPC1 haplotypes with lipid levels.

From: Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

Trait Haplotype (rs1805081-rs1788799, residues) Whole sample Males Females
   BETAa Pvalue BETAa Pvalue BETAa Pvalue
HDL-cholesterol        
  GC (Arg-Ile) -0.047 0.026 -0.070 0.017 -0.020 0.698
  AG (His-Met) -0.013 0.32 0.004 0.803 -0.0278 0.048
  AC (His-Ile) 0.032 0.015 0.025 0.190 0.040 0.023
LDL-cholesterol        
  GC (Arg-Ile) -0.068 0.650 -0.140 0.477 -0.034 0.877
  AG (His-Met) 0.149 0.124 -0.125 0.330 0.200 0.157
  AC (His-Ile) -0.105 0.265 -0.701 0.583 -0.144 0.289
Total cholesterol        
  GC (Arg-Ile) -0.011 0.408 0.003 0.872 -0.028 0.166
  AG (His-Met) 0.010 0.224 0.002 0.873 0.022 0.097
  AC (His-Ile) -0.005 0.538 -0.003 0.794 -0.008 0.505
Triglycerides        
  GC (Arg-Ile) 0.045 0.101 0.104 0.003 -0.0313 0.466
  AG (His-Met) 0.024 0.173 -0.014 0.563 0.071 0.009
  AC (His-Ile) -0.041 0.018 -0.031 0.181 -0.052 0.046
  1. aregression coefficient. Significant P values are in bold.