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Table 2 Completed clinical trials with γ-secretase inhibitors in pediatric/young adult oncologic patients (clinicaltrials.gov).

From: Notch signaling in pediatric soft tissue sarcomas

Compound ClinicalTrials Gov Identifier Clinical studies Cancer type Patients'age
MK0752 NCT00106145 Phase I study Breast and advanced solid tumors 18 Years and older
MK0752 NCT00100152 Phase I study T-ALL 12 Months and oldera
RO4929097 NCT01192763 Phase I study Pancreatic cancer 18 Years and older
RO4929097 NCT01208441 Phase I study Breast cancer 18 Years and older
RO4929097 NCT01269411 Phase I study Brain and Central Nervous System Tumors 18 Years and older
RO4929097 NCT01216787 Phase II study Melanoma (Skin) 18 Years and older
RO4929097 NCT01217411 Phase I study Breast Cancer 18 Years and older
RO4929097 NCT01151449 Phase II study Breast Cancer 18 Years and older
RO4929097 with or without Bevacizumab NCT01270438 Phase II study Metastatic Colorectal Cancer 18 Years and older
RO4929097 NCT01236586 Phase I/II study Brain and Central Nervous System Tumors, T-ALL 1 Year to 21 Yearsa
RO4929097 NCT01088763 Phase I/II study Leukemia 1 Year to 21 Yearsa
  1. aEnrollment of children. T-ALL, T-cell acute lymphoblastic leukemia/lymphoma.