Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography

Table 2 Multiplex proteomics analysis of the coronary artery disease (CAD) and normal (NOR) patient groups

	Average NOR	SD	N	Average CAD	SD	N	Pvalue
OPN	16.4 ng	15.3 ng	149	40.6 ng	38.1 ng	206	< 0.001
VCAM	980.7 ng	493.8 ng	149	1,266.5 ng	492.5 ng	206	< 0.001
APO-A1	293.7 μg	257.4 μg	91	152.5 μg	134.5 μg	135	< 0.001
IL-6	0.6 ng	1.1 ng	101	1.5 ng	1.8 pg	135	< 0.001
MPO	538.2 ng	333.9 ng	147	731.1 ng	532.5 ng	206	< 0.001
IL-1β	56.9 pg	124.0 pg	149	109.0 pg	164.0 pg	206	< 0.005
NT-pBNP	33.3 pg	59.4 pg	91	103.2 pg	204.5 pg	135	< 0.005
Fibrinogen	4.8 μg	5.8 μg	149	25.6 μg	81.6 μg	206	< 0.005
APO-B100	273.2 μg	80.6 μg	149	300.6 μg	93.0 μg	206	< 0.005
Resistin	89.5 ng	63.0 ng	149	110.7 ng	77.0 ng	206	< 0.005
CRP	1.1 μg	2.4 μg	149	3.3 μg	9.7 μg	201	< 0.005
IL-10	3.3 pg	3.7 pg	91	7.6 pg	18.4 pg	135	< 0.005
MMP1	4.7 ng	2.3 ng	91	5.3 ng	2.4 ng	135	0.015 (NS)
Leptin	13.6 ng	18.0 ng	100	10.0 ng	16.0 ng	133	0.027 (NS)
ACRP30	5.9 μg	3.9 μg	149	5.2 μg	4.0 μg	206	0.027 (NS)
MMP7	4.8 ng	3.3 ng	149	5.2 ng	2.4 ng	206	0.045 (NS)
TNFα	22.7 pg	77.1 pg	91	14.7 pg	19.3 pg	135	0.059 (NS)
IFNγ	3.6 pg	10.8 pg	149	4.7 pg	10.0 pg	206	0.069 (NS)
L-selectin	1.1 μg	0.2 μg	91	1.1 μg	0.3 μg	135	0.074 (NS)
MCP1	3.1 ng	3.7 ng	91	3.4 ng	3.4 ng	135	0.114 (NS)
PECAM-1	44.0 ng	32.1 ng	57	45.8 ng	27.2 ng	79	0.116 (NS)
TIMP1	321.3 ng	101.1 ng	91	327.2 ng	86.1 ng	135	0.116 (NS)
E-selectin	33.2 ng	19.2 ng	91	34.1 ng	16.6 ng	135	0.123 (NS)
TM	1.4 ng	0.8 ng	91	1.4 ng	0.4 ng	135	0.128 (NS)

Protein concentrations are reported in pg, ng or μg per ml of serum with adjusted P values for false discovery rate (FDR) at a cut-off for statistical significance between the NOR and CAD groups = 0.01. NS indicates that no significant statistical differences were detected with the calculated P values provided in parenthesis.
ACRP-30 = adiponectin; APO-A1 = apolipoprotein A1; APO-B100 = apolipoprotein B100; CRP = C-reactive protein; E-selectin = endothelial leukocyte adhesion molecule 1; IFNγ = interferon γ; IL = interleukin; L-selectin = leukocyte selectin; MCP-1 = monocyte chemoattractant protein 1; MMP matrix metalloproteinase; MPO = myeloperoxidase; NT-pBNP = N-terminal fragment protein precursor brain natriuretic peptide; OPN = osteopontin; PECAM-1 = platelet endothelial cell adhesion molecule 1; TIMP-1 = tissue inhibitor of metalloproteinase 1; TM = thrombomodulin; TNFα = tumor necrosis factor α; VCAM-1 = vascular cell adhesion molecule 1.

ISSN: 1741-7015