First author, publication date [ref] | Type | Pathology | Patients | Period | Main results | Comments |
---|---|---|---|---|---|---|
Kofoed, 2007 [23] | Prospective | Suspected sepsis | 156 adult, samples taken at ED admission | 12 months | AUC bacterial sepsis: suPAR 0.5, PCT 0.72 CRP 0.81 | |
Yilmaz, 2010 [22] | Retrospective | CCHF | 100 infected adult pts vs volunteers. Samples taken at hospital admission | 2006-2009 38 months | Patients (6.2 ± 4.2 ng/ml) versus controls (2.3 ± 0.6 ng/ml), P < 0.0001. Cut-off 3.06 ng/ml AUC 0.94 (PPV 95%, specificity 92%) | No other infections studied |
Østergaard, 2004 [24] | Prospective | CNS infection | 183 adults, samples taken at admission | 1988 to 2002 | Higher CSF levels in infected patients and in patients with purulent meningitis versus those with lymphocytic meningitis (P < 0.001) | Low sensitivity and specificity (69% and 71%) with cut-off value of 1.50 mcg/l |
Koch, 2011 [26] | Prospective | Critical illness medical ICU | 273 adults, 197 septic patients, samples taken at ICU admission | Undefined | AUC sepsis suPAR 0.615 PCT 0.857 CRP 0.780 | Correlation with renal and hepatic function |
Donadello, 2011 [27] | Prospective | Critical illness medico-surgical ICU | 152 adults, 55 septic patients. Samples taken at ICU admission | December 2010 to March 2011 | AUC sepsis 0.75 (95% CI 0.66 to 0.83); correlation with CRP in global population (r = 0.48), not in septic patients (r = 0.18) | Preliminary data |