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Figure 1 | BMC Medicine

Figure 1

From: Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

Figure 1

Fasudil increases lifespan of Smn 2B/- mice, independent of weight gain and pen test performance. Fasudil (30 mg/kg twice daily) or vehicle (water) was administered by gavage from post-natal (P) day 3 to P21. The different groups analyzed were: untreated wild type (WT) (n = 10), vehicle-treated Smn 2B/+ (n = 8), fasudil-treated Smn 2B/+ (n = 9), vehicle-treated Smn 2B/- (n = 16) and fasudil-treated Smn 2B/- (n = 7). (A) Fasudil significantly increases lifespan of Smn 2B/- mice when compared to vehicle-treated Smn 2B/- mice (*P = 0.0251; # indicates death due to dystocia). Administration of fasudil does not have adverse effects on the lifespan of normal littermates. (B) Fasudil does not prevent the arrest in weight gain that occurs in vehicle-treated Smn 2B/- mice onwards of P10.(C) Fasudil does not improve the performance of Smn 2B/- mice on the pen test when compared to vehicle-treated Smn 2B/- mice.

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