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Figure 10 | BMC Medicine

Figure 10

From: Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab

Figure 10

Enhancement of apoptosis induction by the combination of EGFR siRNA plus gefitinib or erlotinib. Lung cancer cells were treated with different drugs 24 h before the EGFR siRNA transfection. Forty-eight hours post transfection, the cell cultures were assayed for caspase-3/7 activity. (A: gefitinib; B: erlotinib). *P < 0.05 and **P < 0.01 compared to controls with siRNA transfection alone. "black triangle" P < 0.05 and "double black triangles" P < 0.01 compared to agents plus control siRNA.

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