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Table 1 Grades of quality of evidence in GRADE [24]

From: Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-analysis

High = We are very confident that the true effect lies close to that of the estimate of the effect.
Moderate = We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low = Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect.
Very low = We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.