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Table 2 Overview of included trials

From: Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-analysis

Study, year (reference) Comparisons (initial drug-dosages) Sample size (total, included in analysis) Age group (years) Follow-up (mean, years)
VA II 1970 [43] Hydrochlorothiazide (50 mg/day) + reserpine (0.1 mg/day) + hydralazine hydrochloride (25 mg/day) vs. placebo 380 30 to 73 3.3
Oslo hypertension study 1980 [27] Hydrochlorothiazide (50 mg/day) vs. no treatment 785 40 to 49 5.5
EWPHE 1985 [44] Hydrochlorothiazide (25 mg/day) + triamteren (50 mg/day) vs. placebo 840 > 60 4.7
Coope 1986 [45] Atenolol (100 mg/day) or bendrofluazide (5 mg/day) vs. no treatment 884 60 to 79 4.4
HAPPHY 1987 [28] Bendroflumethiazide (5 mg/day) or hydrochlorothiazide (50 mg/day) vs. atenolol (100 mg/day) or metoprolol 200 mg/day) 6,569 40 to 64 3.8
STOP 1 1991 [46] Atenolol (50 mg/day) or HCTZ (25 mg/day) (add-on drugs: amiloride (2.5 mg/day) or metoprolol (100 mg/day) or pindolol (5 mg/day)) vs. placebo 1,627 70 to 84 2
SHEP 1991 [26] Chlortalidone (12.5 mg/day) vs. placebo 4,736 > 60 4.5
MRC 2 1992 [29] Hydrochlorothiazide+amiloride (25 + 2.5 mg/day) vs. atenolol (50 mg/day) vs. placebo 4,396 65 to 74 5.8
SYST-EUR 1997 [47] Nitrendipine (10 mg/day) vs. placebo 4,695 > 60 4
Sun 1997 [25] Nitrendipine (10 mg/day) (starting dose: 10 mg × 3, reduced to 10 mg × 1) vs. usual care 2,080 > 15 4.7
CAPPP 1999 [30] Captopril (50 mg/day) vs. atenolol (50 to 100 mg/day) or metoprolol (50 to 100 mg/day) or hydrochlorothiazide (25 mg/day) or bendroflumethiazide (2.5 mg/day) 10,985 25 to 66 6.1
NICS-EH 1999 [31] Nicardipine (20 mg × 2/day) vs. Trichlormethiazide (2 mg/day) 414 ≥ 60 4.6 (nicardipine group) and 3.9 (trichlormethia-zide group)
STOP-2 1999 [32] Atenolol (50 mg/day) or metoprolol (100 mg/day) or pindolol (5 mg/day) or hydrochlorothiazide (25 mg/day)+amilorid (2.5 mg/day) vs. enalapril (10 mg/day) or lisinopril (10 mg/day) vs. felodipine (2.5 mg/day) or isradipine (2.5 mg/day) 6,614 70 to 84 4 to 6
ALLHAT 2000, 2002 [10, 33] Doxazosine (2 mg/day) vs. chlorthalidone (12.5 mg/day) vs. amlodipine (2.5 mg/day) vs. lisinopril (10 mg/day) 42,424 > 55 4.9 for chlorthalidone vs. amlodipine vs. lisinopril.
3.3 (median) for chlorthalidone vs. doxazosine
NORDIL 2000 [34] Diltiazem (180 to 360 mg/day) vs. thiazide (not specified) or beta-blocker (not specified) 10,881 50 to 74 4.5
INSIGHT 2000 [35] Nifedipine (30 mg/day) vs. hydrochlorothiazide (25 mg/day)+amilorid (2.5 mg/day) 6,321 55 to 80 ~3.5
LIFE 2002 [36] Losartan (50 mg/day) vs. atenolol (50 mg/day) 9,193 55 to 80 4.8
ANBP 2 2003 [37] ACE-inhibitor (unspecified type and dosage) vs. thiazide-diuretic (unspecified type and dosage) 6,083 65 to 84 4.1
CONVINCE 2003 [38] Verapamil (180 mg/day) vs. atenolol (50 mg/day) or hydrochlorothiazide (12.5 mg/day) 16,602 > 55 3
HYVET-PILOT 2003 [39] Lisinopril (2.5 mg/day) vs. bendroflumethiazide (2.5 mg/day) vs. no treatment 857 > 80 1.1
SHELL 2003 [40] Chlorthalidone (12.5 mg/day) vs. lacidipine (4 mg/day) 1,882 > 60 2.7 (median)
VALUE 2004 [49] Valsartan (80 mg/day) vs. amlodipine (5 mg/day) 15,245 > 50 4.2
E-COST 2005 [41] Candesartan (4 or 8 mg/day) vs. "conventional based regimen" 1,630 35 to 79 3.1
CASE-J 2008 [42] Candesartan (8 mg/day) vs. amlodipine (5 mg/day) 4,703 63.8 (mean) 3.2
HYVET 2008 [48] Indapamid (1.5 mg/day) vs. placebo 3,845 ≥ 80 2.1