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Table 6 Effect estimates from multiple-treatment meta-analysis (MTM) compared to direct and indirect estimates, based on node-splitting [23]

From: Comparative effectiveness of antihypertensive medication for primary prevention of cardiovascular disease: systematic review and multiple treatments meta-analysis

  Outcome MTM-estimate (95% Crl) Direct estimate (95% Crl) Indirect estimate (95% Crl) P-value for inconsistency
Diuretics vs. beta-blockers Diabetes- incidence 1.09 0.88 1.31 0.13
   (0.80 to 1.44) (0.59 to 1.32) (0.88 to 2.17)  
Diuretics vs. ACE-inhibitors Diabetes- incidence 1.43 1.54 1.25 0.24
   (1.12 to 1.83) (1.14 to 2.10) (0.89 to 1.79)  
Diuretics vs. placebo All-cause mortality 0.88 0.89 0.80 0.29
   (0.80 to 0.95) (0.82 to 0.97) (0.68 to 0.96)  
Beta-blockers vs. ARB Stroke 1.23 1.34 1.00 0.17
   (0.96 to 1.49) (1.03 to 1.74) (0.69 to 1.41)  
Beta-blockers vs. ARB Diabetes- incidence 1.46 1.32 1.98 0.13
   (1.15 to 1.98) (0.97 to 1.82) (1.26 to 3.40)  
ACE- inhibitors vs. CCB All-cause mortality 1.02 1.05 0.95 0.21
   (0.95 to 1.10) (0.96 to 1.13) (0.82 to 1.09)  
ACE- inhibitors vs. CCB Heart fail ure 0.82 0.79 0.68 0.29
   (0.69 to 0.94) (0.67 to 0.95) (0.52 to 0.90)  
ACE-inhibitors vs. placebo All-cause mortality 0.87 1.30 0.86 0.08
   (0.79 to 0.96) (0.82 to 2.14) (0.77 to 0.95)  
Diuretics and/or beta-blockers vs. placebo All-cause mortality 0.82 0.57 0.85 0.06
   (0.73 to 0.92) (0.34 to 0.84) (0.75 to 0.96)  
CCB vs. ARB Stroke 0.91 0.86 1.15 0.19
   (0.75 to 1.11) (0.69 to 1.05) (0.78 to 1.70)  
CCB vs. ARB Diabetes- incidence 1.25 1.29 0.86 0.14
   (1.02 to 1.56) (1.07 to 1.71) (0.49 to 1.49)  
  1. Table is limited to comparisons where Bayesian "P-values" for inconsistency were < 0.3. For a complete overview of MTM-, direct, and indirect estimates see Additional file 6