Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery

Table 5 List of pancreas tissue-specific proteins which have not been previously studied as serum cancer or benign disease biomarkers

Gene	Protein name	Proteome identified in:
		CM proteome from pancreatic cancer cell lines [33]	Pancreatic cancer ascites proteome [32]	Pancreatic juice proteome [33]	Pancreatic tissue^a		Non-pancreas proteome
					Normal	Cancer
*AQP8*	Aquaporin 8
*CTRB1*	Chymotrypsinogen B1		√				√ Down Syndrome amniotic fluid [22]
*CTRB2*	Chymotrypsinogen B2			√	√
*CTRC*	Chymotrypsin C (caldecrin)			√	√	√
*CUZD1*	CUB and zona pellucida-like domains 1			√	√
*KLK1*	Kallikrein 1			√	√	√
*PNLIPRP1*	Pancreatic lipase-related protein 1			√	√
*PNLIPRP2*	Pancreatic lipase-related protein 2			√	√		√ CM proteome from Hep 3B [52]
*PRSS3*	Protease, serine, 3		√	√	√	√	√ HCC-38^b; HCC-1143^b; normal amniotic fluid [23]
*REG1B*	Regenerating islet-derived 1 beta			√	√	√
*REG3G*	Regenerating islet-derived 3 gamma			√			√ Seminal plasma proteome [25]
*SLC30A8*	Solute carrier family 30 (zinc transporter), member 8

^aProteome of normal and cancer pancreatic tissue (H Kosanam et al., unpublished work); ^bCM proteome of breast cancer cell lines (M Pavlou et al., unpublished work). CM: conditioned media.

ISSN: 1741-7015