Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery

Table 6 List of prostate-specific proteins which have not been previously studied as serum cancer or benign disease biomarkers

Gene	Protein name	Proteome identified in:
		CM proteome from prostate cancer cell lines	Seminal plasma proteome[25]	Non-prostate proteome
*NPY*	Neuropeptide Y	√ VCaP^a	√
*PSCA*	Prostate stem cell antigen	√ PC3 [28]	√	√ Normal and cancer pancreatic tissue^b; CM proteome from pancreatic cancer cell lines SU.86.86, CAPAN1 [33]
*RLN1*	Relaxin 1
*SLC45A3*	Solute carrier family 45, member 3

^aCM proteome from prostate cancer cell line (P Saraon et al., unpublished work); ^bproteome of normal and cancer pancreatic tissue (H Kosanam et al., unpublished work). CM: conditioned media.

ISSN: 1741-7015