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Table 2 Distribution of the genotype in selected SNPs of MMR genes

From: Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility

Gene tSNP Controls MAF Case1aMAF P c Case2b
MAF
P c
MLH1       
  rs1799977 0.023 0.028 0.628 0.025 0.828
  rs4647269 0.047 0.075 0.032 0.067 0.175
  rs1540354 0.304 0.343 0.326 0.331 0.428
PMS2       
  rs3815383 0.332 0.332 0.923 0.342 0.816
  rs2286680 0.074 0.080 0.772 0.089 0.491
  rs11769380 0.410 0.419 0.816 0.379 0.736
  rs1059060 0.091 0.146 0.003 0.170 2.0 × 10 -4
  rs2228006 0.063 0.054 0.520 0.056 0.582
MLH3       
  rs13712 0.184 0.185 0.913 0.185 0.962
  rs7156586 0.222 0.217 0.832 0.406 0.527
  rs175049 0.185 0.173 0.646 0.177 0.727
MSH4       
  rs1021462 0.309 0.336 0.592 0.317 0.842
MSH5       
  rs3749953 0.121 0.154 0.278 0.148 0.653
  rs1150793 0.142 0.141 0.960 0.138 0.827
  rs707939 0.359 0.337 0.582 0.357 0.886
  rs707938 0.304 0.331 0.557 0.336 0.231
  rs3115672 0.375 0.402 0.681 0.377 0.929
  rs3117572 0.223 0.206 0.724 0.231 0.782
  rs2299850 0.063 0.056 0.652 0.068 0.720
  rs9461718 0.144 0.161 0.472 0.157 0.567
  rs2075789 0.081 0.139 0.002 0.097 0.485
  1. Abbreviations: MAF, minor allele frequency.
  2. aCase 1: idiopathic infertile men with azoospermia or oligozoospermia.
  3. bCase 2: idiopathic infertile men with normal sperm count.
  4. Data in bold highlights the statistic significant results.
  5. cFalse Discovery Rate (FDR) corrected P-value.
  6. Data in boldface represent P < 0.05.