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Table 2 Distribution of the genotype in selected SNPs of MMR genes

From: Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility

Gene

tSNP

Controls MAF

Case1aMAF

P c

Case2b

MAF

P c

MLH1

      
 

rs1799977

0.023

0.028

0.628

0.025

0.828

 

rs4647269

0.047

0.075

0.032

0.067

0.175

 

rs1540354

0.304

0.343

0.326

0.331

0.428

PMS2

      
 

rs3815383

0.332

0.332

0.923

0.342

0.816

 

rs2286680

0.074

0.080

0.772

0.089

0.491

 

rs11769380

0.410

0.419

0.816

0.379

0.736

 

rs1059060

0.091

0.146

0.003

0.170

2.0 × 10 -4

 

rs2228006

0.063

0.054

0.520

0.056

0.582

MLH3

      
 

rs13712

0.184

0.185

0.913

0.185

0.962

 

rs7156586

0.222

0.217

0.832

0.406

0.527

 

rs175049

0.185

0.173

0.646

0.177

0.727

MSH4

      
 

rs1021462

0.309

0.336

0.592

0.317

0.842

MSH5

      
 

rs3749953

0.121

0.154

0.278

0.148

0.653

 

rs1150793

0.142

0.141

0.960

0.138

0.827

 

rs707939

0.359

0.337

0.582

0.357

0.886

 

rs707938

0.304

0.331

0.557

0.336

0.231

 

rs3115672

0.375

0.402

0.681

0.377

0.929

 

rs3117572

0.223

0.206

0.724

0.231

0.782

 

rs2299850

0.063

0.056

0.652

0.068

0.720

 

rs9461718

0.144

0.161

0.472

0.157

0.567

 

rs2075789

0.081

0.139

0.002

0.097

0.485

  1. Abbreviations: MAF, minor allele frequency.
  2. aCase 1: idiopathic infertile men with azoospermia or oligozoospermia.
  3. bCase 2: idiopathic infertile men with normal sperm count.
  4. Data in bold highlights the statistic significant results.
  5. cFalse Discovery Rate (FDR) corrected P-value.
  6. Data in boldface represent P < 0.05.