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Table 2 Example of the REMARK profile illustrated using data from a study of ploidy in patients with advanced ovarian cancer [157] (from [20]).

From: Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration

a) Patients, treatment and variables
Study and marker Remarks
Marker (If non-binary: how was marker analyzed? continuous or categorical. If categorical, how were cutpoints determined?) M = ploidy (diploid, aneuploid)
Further variables
(variables collected, variables available for analysis, baseline variables, patient and tumor variables)
v1 = age, v2 = histologic type, v3 = grade, v4 = residual tumor, v5 = stage, v6 = ascitesa, v7 = estrogena, v8 = progesteronea, v9 = CA-125a
Patients n Remarks
Assessed for eligibility 257 Disease: Advanced ovarian cancer, stage III and IV
Patient source: Surgery 1982 to 1990, University Hospital Freiburg
Sample source: Archived specimens available
Excluded 73 General exclusion criteriab, non-standard therapyb, coefficient of variation > 7%b
Included 184 Previously untreated.
Treatment: all had platinum based chemotherapy after surgery
With outcome events 139 Overall survival: death from any cause
b) Statistical analyses of survival outcomes
Analysis Patients Events Variables considered Results/remarks
A1: Univariable 184 139 M, v1 to v5 Table 2, Figure 1
A2: Multivariable 174 133 M, v1, v3 to v5 Table 3 [v2 omitted because many missing data; Backward selection, see text]
A3: Effect for ploidy adjusted for v4 184 139 M, v4 Figure 2 [Based on result of A2]
A4: Interaction: ploidy and stage 175 133 M, v1, v2, v4, v5 See text
A5: Ploidy in stage subgroups     
v5 = III 128 88 M Figure 3
v5 = IV 56 51 M Figure 4
  1. aNot considered for survival outcome as these factors are not considered as 'standard' factors and/or number of missing values was relatively large; bvalues not given in the paper.