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Table 8 Univariable analyses of relation of UBE2C protein and standard variables to overall survival in 92 women with node-positive breast cancer [183].

From: Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration

Variable HR 95% CI P
Age 1.06 1.01 to 1.12 0.026
Histology (IDC versus others) 0.48 0.18 to 1.27 0.139
Histological size (<20 mm versus ≥20 mm) 2.97 0.68 to 12.94 0.147
SBR (I versus II versus III) 3.97 1.67 to 9.47 0.001
Positive nodes (1 versus 2 versus 3 versus >3) 1.81 1.19 to 274 0.005
Estrogen receptor (+versus -) 0.18 0.07 to 0.47 <0.001
Progesterone receptor (+versus -) 0.51 0.19 to 1.37 0.182
IHC Ki-67 (<11% versus ≥11%) 8.59 1.14 to 64.57 0.037
IHC UBE2C (<11% versus ≥11%) 7.14 1.64 to 31.11 0.009
NPI scores (1 versus 2 versus 3) 4.48 1.74 to 11.52 0.002
  1. CI: confidence interval; IDC: infiltrating ductal carcinoma; IHC: immunohistochemistry; HR: hazard ratio; NPI: Nottingham Prognostic Index; SBR: Scarff-Bloom-Richardson.