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Table 1 Examples of immune effects induced by histamine or histamine receptor-2 agonists

From: Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis

Agent Organism/cell type Response Reference
Dimaprit Mice Attenuates experimental autoimmune encephalomyelitis disease activity [23]
Dimaprit
Histamine
Mouse activated T cells Suppresses T cell proliferation, IL-6, IL-10, IL-17 and IFN-γ production [24]
H2 agonist
Histamine (reversed by H2R antagonist)
Human neutrophils Decreases neutrophil chemotaxis response [44]
H2 agonist
Histamine (reversed by H2R antagonist)
Human T cells Decreases T cell proliferation [44]
H2R agonists
Histamine (reversed by H2R antagonist)
Human peripheral blood mononuclear cells Inhibits secretion of IL-1 and IL-12, and stimulates production of IL-10 [28, 29, 31]
Histamine
(reversed by H2R antagonist)
Human peripheral blood mononuclear cells Inhibits secretion of TNF-α [30]
Histamine
(reversed by H2R antagonist)
Human DCs Suppresses IL-12 production following lipopolysaccharide stimulation of DCs [73]
Histamine
(reversed by H2R antagonist)
Human DCs Promotes Th2 response, that is, upregulation of Th2 chemokine production, by immature DCs [74]
Histamine
(reversed by H2R antagonist)
Rat mast cells Suppresses TNF-α production [33]
Histamine
(reversed by H2R antagonist)
Human umbilical vein endothelial cells Stimulates production of IL-6 [39]
  1. DC: dendritic cell; H2R: histamine receptor-2; IFN-γ: interferon gamma; IL: interleukin; Th: T helper cell; TNF-α: tumor necrosis factor alpha.