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Table 2 Examples of immune effects by histamine receptor-2 antagonists

From: Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis

Agent Cell/whole animal Response Reference
Cimetidine Guinea pigs Increases activity of delayed type hypersensitivity and experimental autoimmune encephalomyelitis incidence [25]
Cimetidine Mouse T cells Inhibits induction of T suppressor cells [45]
Cimetidine Mouse splenocytes Increases antibody production, and proliferation of mitogen-activated splenocytes in response to tetanus toxoid [51]
Cimetidine Mouse T cells Inhibits regulatory T cell-like activity [49]
Cimetidine Human T cells Reduces suppressor T cell response [46]
Cimetidine Human lymphocytes Increases the mitogen-activated T cell response [42, 43]
Cimetidine Human DCs Increases the capacity of antigen presentation by DCs from immunosuppressed cancer patients [75]
Ranitidine Human T cells Increases CD4+ T cells and mitogen-stimulated IFN-γ production from patients with head injury [52]
Ranitidine Human monocytes, neutrophils, natural killer cells, delayed type hypersensitivity Reverses surgery-induced immune suppression [54, 55]
  1. DC: dendritic cell; IFN-γ: interferon gamma.