Table 4 Estimates of diagnostic precision of various markers and outcomes in single studies.
Citation | Marker and Cutpoint | Outcome | Sensitivity (95% CI) | Specificity 95% CI) |
|---|---|---|---|---|
Santolaya 2008 | IL8 200 | Sepsis | 0.49 (0.4 to 0.58) | 0.71 (0.67 to 0.75) |
Diepold 2008 | IL8 30 | Prolonged illness | 0.87 (0.78 to 0.93) | 0.61 (0.42 to 0.76) |
Diepold 2008 | IL8 90 | Bacterial infection | 0.64 (0.39 to 0.84) | 0.62 (0.52 to 0.71) |
El-Maghraby 2007 | IL8 62 | Documented infection | 0.71 (0.59 to 0.81) | 0.77 (0.58 to 0.89) |
Lehrnbecher 2004 | IL8 320 | Documented infection | 0.56 (0.46 to 0.65) | 0.79 (0.73 to 0.84) |
Lehrnbecher 2004 | IL8 500 | Documented infection | 0.44 (0.35 to 0.54) | 0.89 (0.84 to 0.93) |
El-Maghraby 2007 | MCP 350 | Documented infection | 0.64 (0.52 to 0.75) | 0.92 (0.76 to 0.98) |
Hitoglou-Hatzi 2005 | tADA 35 U/l | Significant bacterial infection | 1.0 (0.88 to 1.0) | 1.0 (0.91 to 1.0) |
Riikonen 1992 | TNF 40 | Bacteremia or focal infection | 1.0 (0.88 to 1.0) | 0.07 (0.03 to 0.15) |
Hodge 2006 | IL5 17 | Positive blood culture | 0.5 (0.22 to 0.79) | Could not calculate |
Hodge 2006 | IL5 and 8 combined > 17 and > 220 | Positive blood culture | 1.0 (0.68 to 1.0) | 0.87 (0.68 to 0.96) |
Soker 2001 | IL-2R | Bacteremia | Median (range) 5,230 U/mL (1,120 to 7,600) | 1,190 (724 to 5,400) |
Soker 2001 | TNF-alpha | Bacteremia | 8.4 (4.0 to 68.2) | 7.8 (3.0 to 37.2) |
Secmeer 2007 | ESR | Bacteremia | "not statistically significantly different between patients with and without documented infection" | Â |