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Figure 2 | BMC Medicine

Figure 2

From: Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models

Figure 2

Phenethyl isothiocyanate (PEITC) downregulates HER2 signaling in breast cancer cells. (A) MDA-MB-231 and (B) MCF-7 cells were treated with varying concentrations of PEITC for 24 h. Representative blots showing the concentration dependent effect of PEITC on HER2, epidermal growth factor receptor (EGFR), phosphorylated signal transducer and activator of transcription 3 (p-STAT3) (Y705), BIM, BCL-2-associated × (BAX), B-cell lymphoma-extra large (BCL-XL), X-linked inhibitor of apoptosis protein (XIAP), BH3 interacting-domain death agonist (BID), cleaved caspase 3 and cleaved poly-ADP ribose polymerase (PARP). Actin was used as internal loading control. Each experiment was repeated three times independently.

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