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Table 6 Summary of clinical studies with bioresorbable membranes for reconstruction of segmental mandibular defects

From: The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence

Author/Year [ref] Study design No. of pts Mandibular reconstruction Defect size Etiology Type of membrane Graft Type of fixation Outcome
Kinoshita
2004 [33]
case series (1995 to 2001) 62 Mandibulectomy (segmental defect and hemimandibulectomy) _ malignant (22) and benign (30) tumors, cysts (5), osteomyelitis (2), alveolar atrophy (1) trauma (2) Absorbable
PLLA mesh
Autologous cancellous bone graft
+ bone marrow
+/- stainless steel wires At six months post-operation:
Excellent (markedly effective) 56.5%
Good (effective) 27.4%
Poor (not effective) 16.1%
X-ray of the regenerated bone: 0 to 10% bone resorption in 31 cases
10% to 20% in six cases
20% to 30% in one case
Kinoshita
2000 [133]
case series (1995 to 1998) 41 Segmental defect or large partial defects mandibulectomy _ malignant (19) and benign (22) tumors    - Excellent: 19/41 (46.3%)
Good 13/41 (31.7%)
Poor 9/41 (22.2%) (local infection)
86.5% Success rate
Five years: no problems from PLLA and good osseointegration
Kinoshita
1996 [57]
case series 2 Segmental defect or large partial defect right to left molar areas tumor    stainless steel wires At three months: full bone regeneration