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Table 2 The correlations between the frequencies of circulating GLK-expressing T-cells, the relative expression levels of GLK protein, GLK transcript and disease activity parameters as well as Th17-related cytokines in 24 patients with adult-onset Still's disease

From: Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker

  Circulating GLK-expressing T-cells (%) Relative expression levels of GLK protein Relative expression levels of GLK transcript
Clinical activity scores 0.599** 0.435* 0.452*
C-reactive protein (mg/dL) 0.455* 0.315 0.364
Ferritin (μg/L) 0.508* 0.296 0.318
Soluble IL-2R (pg/mL) 0.865*** 0.569** 0.803***
IL-1β (pg/mL) 0.281 0.152 0.063
IL-6 (pg/mL) 0.822*** 0.423* 0.547**
IL-17A (pg/mL) 0.787*** 0.699*** 0.740***
TNF-α (pg/mL) 0.295 0.177 0.310
  1. GLK: germinal center kinase-like kinase; IL: interleukin; IL-2R: interleukin-2 receptor; TNF-α: tumor necrosis factor-alpha. *P <0.05, **P <0.005, ***P <0.001 obtained by the nonparametric Spearman's rank correlation test.