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Table 2 Overview of ranges during pregnancy per tumor marker.

From: Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review

  Normal oncologic cut-off values in non-pregnant women Trimester 1a Trimester 2 Trimester 3 References
Carbohydrate antigen 15-3b <30 U/mL 5.0 to 39.3 1.0 to 40 7.0 to 56 [7, 11, 51, 52]
   1.3 to 19.5 4.0 to 24.4 7.0 to 27 [6, 7]
Squamous cell carcinoma antigen <2 µg/L 0.3 to 2.9 0.1 to 2.2 0.6 to 4.3 [7]
   0 to 1.97 0.51 to 1.99 0 to 2.22 [6]
Carbohydrate antigen 125 <39 U/mL 3.7 to 550 1 to 166.6 6.1 to 2,419.7 [7, 10, 11, 13, 14, 17, 18]
   0 to 215.1 0 to 308 0 to 56.3 [15, 16]
Inhibin B ng/mL NA NA NA NA
   22.06 to 32.94 19.88 to 56.12 58.62 to 171.38 [19]
Anti-Müllerian hormone ng/mL 0.2 to 9.3 0.5 to 4.0 0.2 to 3 [22, 23]
   NA NA NA NA
Lactate dehydrogenase <221 U/L 78 to 433 80 to 447 82 to 524 [2528]
   NA NA NA NA
  1. NA, not applicable. aThe definition of first, second and third trimester is the one used in the study and differs from one study to the other; b for each parameter the non-pregnant reference value is the mean of all studies, whereas lowest and highest ranges and 2.5 to 97.5 percentiles in the three pregnancy trimesters are presented in the first and the second row, respectively.