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Table 2 Differences between groups NAC and placebo on scores at Week 8 (at randomization) in terms of symptoms and functioning.

From: Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

Characteristics Descriptive statistic Total sample n = 149 NAC n = 76 Placebo n = 7 3 Test statistic Value df P
Symptoms         
   YMRSa M(SD) 1.5 (2.1) 1.7 (2.4) 1.4 (1.9) t-test 0.37 130 .716
   MADRSb M(SD) 12.6 (9.8) 13.1 (9.72) 12.2 (9.9) t-test 0.47 130 .638
   BDRSa M(SD) 10.7 (9.1) 11.3 (8.5) 10.1 (9.7) t-test 1.20 130 .233
   CGI-BP Severity         
Depressiona M(SD) 2.8 (1.2) 2.9 (1.2) 2.8 (1.2) t-test 0.49 129 .625
Maniaa M(SD) 1.3 (0.7) 1.4 (0.7) 1.3 (0.6) t-test 0.17 129 .620
Overalla M(SD) 2.9 (1.2) 2.9 (1.2) 2.8 (1.2) t-test 0.29 128 .771
   CGI-BP Improvement         
   Depressiona M(SD) 2.5 (1.2) 2.5 (1.1) 2.6 (1.3) t-test -0.17 129 .864
   Maniaa M(SD) 3.8 (0.7) 3.8 (0.7) 3.9 (0.7) t-test -0.63 130 .533
   Overalla M(SD) 2.6 (1.2) 2.6 (1.2) 2.7 (1.3) t-test -0.30 129 .767
Functioning         
   GAF M(SD) 72.2 (13.7) 71.1 (13.3) 73.3 (14.1) t-test -0.92 129 .360
   SOFAS M(SD) 72.1 (13.6) 71.5 (13.0) 72.6 (14.1) t-test -0.46 129 .649
   LIFE-RIFT M(SD) 11.2 (3.8) 11.5 (3.9) 10.9 (3.8) t-test 0.83 130 .410
   SLICE-LIFE M(SD) 16.5 (5.2) 16.6 (5.3) 16.5 (5.0) t-test 0.17 130 .866
Q-LES-Q M(SD) 53.4 (10.8) 52.5 (10.6) 54.3 (11.0) t-test -0.98 130 .325
  1. YMRS, Young Mania Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; BDRS, Bipolar Depression Rating Scale; CGI-BP Clinical Global Impressions - Bipolar Disorder; GAF, Global Assessment of Functioning; SOFAS, Social and Occupational Assessment Scale; Q-LES-Q, Quality of Life Enjoyment and Satisfaction Questionnaire. aInferential statistics based on logarthmic transformed data (plus constant) because of extreme positive skewness. Untransformed descriptive statistics are reported; bInferential statistics based on square root transformed data (plus constant) because of positive skewness. Untransformed descriptive statistics are reported.