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Table 3 Tests of fixed effects in MMRM for measures of psychopathology and functioning.

From: Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

Effect F test df Pvalue   F test df Pvalue
Symptoms        
   YMRS †     MADRS Total Score†    
Group 2.04 1, 113.4 .156 Group 0.26 1, 121.7 .610
Time 1.45 6, 285.4 .197 Time 3.15 6, 240.6 .005
Group by time 0.99 6, 285.4 .432 Group by time 0.44 6, 240.6 .855
   BDRS †        
Group 0.27 1, 124.8 .604     
Time 3.83 6, 245.2 .001     
Group by time 0.49 6, 245.2 .813     
   CGI-BP Severity Depression †     CGI-BP Improvement Depression †   
Group 0.03 1, 126.0 .863 Group 0.14 1, 123.6 .709
Time 1.03 6, 197.4 .405 Time 2.43 6, 341.8 .026
Group by time 0.60 6, 197.4 .731 Group by time 0.54 6, 341.8 .777
   CGI-BP Severity Mania †     CGI-BP Improvement Mania†    
Group 0.01 1, 116.0 .935 Group 0.05 1, 124.3 .822
Time 0.38 6, 247.2 .893 Time 1.99 6, 303.2 .066
Group by time 0.75 6, 247.2 .614 Group by time 1.32 6, 303.2 .248
   CGI-BP Severity Overall †     CGI-BP Improvement Overall†    
Group 0.15 1, 122.7 .704 Group 0.05 1, 125.3 .828
Time 1.31 6, 201.0 .255 Time 3.10 6, 335.6 .006
Group by time 0.47 6, 201.0 .829 Group by time 0.38 6, 335.6 .893
Functioning        
   GAF     SOFAS    
Group 1.60 1, 121.9 .209 Group 0.46 1, 121.7 .500
Time 2.90 6, 252.9 .010 Time 4.43 6, 311.8 <.001
Group by time 0.75 6, 252.9 .609 Group by time 0.95 6, 311.8 .460
   LIFE-RIFT     SLICE-LIFE    
Group 0.95 1, 121.4 .332 Group 0.12 1, 119.8 .732
Time 1.09 6, 242.0 .370 Time 0.86 6, 275.5 .525
Group by time 0.52 6, 242.0 .794 Group by time 0.62 6, 275.5 .714
   QLESQ        
Group 0.53 1, 123.2 .466     
Time 1.99 6, 265.4 .067     
Group by time 0.16 6, 265.4 .987     
  1. YMRS, Young Mania Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; BDRS, Bipolar Depression Rating Scale; CGI-BP Clinical Global Impressions - Bipolar Disorder; GAF, Global Assessment of Functioning; SOFAS, Social and Occupational Assessment Scale; LIFE-RIFT, Range of Impaired Functioning Tool; SLICE-LIFE, Streamed Longitudinal Interval Clinical Evaluation of the Longitudinal Interview Follow-Up Evaluation; Q-LES-Q, Quality of Life Enjoyment and Satisfaction Questionnaire. † Inferential statistics based on logarithmic transformed data (plus constant) because of extreme positive skewness.