| Change from Week 8 to Week 32 |  |  |  | |
---|---|---|---|---|---|
Characteristics | NAC | Placebo | tb | df | P |
 | M (SE)a | M (SE) |  |  |  |
Symptoms | Â | Â | Â | Â | Â |
   YMRS†| 0.1 (0.4) | 0.4 (0.4) | -0.68 | 129.7 | .500 |
   MADRS††| 0.6 (1.5) | 1.5 (1.5) | -0.42 | 141.3 | .679 |
   BDRS†| 1.4 (1.4) | 0.7 (1.3) | 0.35 | 139.0 | .726 |
   CGI-BP - Severity†|  |  |  |  |  |
Depression | -0.1 (0.2) | -0.3 (0.2) | 0.5 | 186.5 | .615 |
Mania | 0.1 (0.1) | -0.1 (0.1) | 0.22 | 160.7 | .826 |
Overall | 0.1 (0.2) | -0.2 (0.2) | 0.46 | 167.4 | .646 |
CGI-BP - Improvement | Â | Â | Â | Â | Â |
   Depression | 0.1 (0.3) | 0.2 (0.3) | -0.24 | 105.6 | .814 |
   Mania C | -0.2 (0.2) | 0.0 (0.2) | -1.23 | 67.6 | .222 |
Overall | 0.1 (0.3) | 0.3 (0.3) | -0.39 | 93.4 | .695 |
Functioning | Â | Â | Â | Â | Â |
   GAF | -3.2 (1.8) | -4.4 (1.7) | 0.54 | 136.7 | .593 |
   SOFAS | -3.6 (1.8) | -4.5 (1.7) | 0.36 | 165.0 | .719 |
   LIFE-RIFT | 0.5 (0.5) | 1.1 (0.5) | -0.76 | 100.5 | .449 |
   SLICE-LIFE | 0.2 (0.8) | 1.2 (0.8) | -0.89 | 107.4 | .376 |
QLESQ | -1.7 (1.8) | -2.0 (1.7) | 0.14 | 120.5 | .890 |