From: Intracranial hemorrhage in adult patients with hematological malignancies
 | Number of patients | |||||
---|---|---|---|---|---|---|
Subtype | AML (n = 43) | APL (n = 9) | ALL (n = 5) | Lymphoma (n = 7) | Myeloma (n = 8) | Pvalue |
Age: | Â | Â | Â | Â | Â | 0.094 |
≥60 years | 19 | 2 | 1 | 6 | 4 |  |
<60 years | 24 | 7 | 4 | 1 | 4 | Â |
Gender: | Â | Â | Â | Â | Â | 0.461 |
Male | 32 | 5 | 2 | 4 | 5 | Â |
Female | 11 | 4 | 3 | 3 | 3 | Â |
Underlying hypertension: | Â | Â | Â | Â | Â | 0.428 |
Yes | 12 | 3 | 0 | 3 | 1 | Â |
No | 31 | 6 | 5 | 4 | 7 | Â |
Diabetes mellitus: | Â | Â | Â | Â | Â | 0.274 |
Yes | 3 | 1 | 0 | 2 | 0 | Â |
No | 40 | 8 | 5 | 5 | 8 | Â |
Sepsis: | Â | Â | Â | Â | Â | 0.096 |
Yes | 16 | 5 | 5 | 4 | 4 | Â |
No | 27 | 4 | 0 | 3 | 4 | Â |
Post HSCT: | Â | Â | Â | Â | Â | 0.347 |
Yes | 8 | 0 | 0 | 0 | 1 | Â |
No | 35 | 9 | 5 | 7 | 7 | Â |
Disease status: | Â | Â | Â | Â | Â | 0.409 |
Remission | 6 | 2 | 0 | 0 | 0 | Â |
Active | 37 | 7 | 5 | 7 | 8 | Â |
CNS involvement: | Â | Â | Â | Â | Â | <0.001 |
Yes | 0 | 0 | 0 | 5 | 1 | Â |
No | 43 | 9 | 5 | 2 | 7 | Â |
Leukocyte count: | Â | Â | Â | Â | Â | 0.642 |
≥100,000 cells/μl | 9 | 2 | 0 | 1 | 0 |  |
<100,000 cells/μl | 34 | 7 | 5 | 6 | 8 |  |
Platelet count: | Â | Â | Â | Â | Â | 0.560 |
≥20,000 cells/μl | 27 | 6 | 3 | 6 | 4 |  |
<20,000 cells/μl | 16 | 3 | 2 | 1 | 4 |  |
Prothrombin time: | Â | Â | Â | Â | Â | 0.493 |
INR ≥1.5 | 10 | 2 | 1 | 1 | 1 |  |
INR <1.5 | 32 | 7 | 4 | 6 | 7 | Â |
Location: | Â | Â | Â | Â | Â | Â |
Cerebral cortex | 37 | 7 | 5 | 4 | 5 | 0.326 |
Basal ganglia | 9 | 1 | 1 | 1 | 1 | 0.941 |
Brainstem | 4 | 0 | 0 | 1 | 0 | 0.628 |
Cerebellum | 4 | 2 | 0 | 1 | 3 | 0.213 |
Multiple | 20 | 5 | 0 | 3 | 5 | 0.240 |
Type: | Â | Â | Â | Â | Â | Â |
Intraparenchymal hemorrhage | 35 | 7 | 5 | 4 | 5 | 0.336 |
Subarachnoid hemorrhage | 8 | 2 | 2 | 0 | 3 | 0.349 |
Subdural hemorrhage | 11 | 2 | 1 | 4 | 4 | 0.307 |
Epidural hemorrhage | 1 | 0 | 0 | 0 | 2 | 0.041 |
Intraventricular hemorrhage | 10 | 4 | 1 | 3 | 2 | 0.618 |