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Table 1 Clinical characteristics of intracranial hemorrhage among patients of different types of hematological malignancies

From: Intracranial hemorrhage in adult patients with hematological malignancies

  Number of patients
Subtype AML (n = 43) APL (n = 9) ALL (n = 5) Lymphoma (n = 7) Myeloma (n = 8) Pvalue
Age:       0.094
≥60 years 19 2 1 6 4  
<60 years 24 7 4 1 4  
Gender:       0.461
Male 32 5 2 4 5  
Female 11 4 3 3 3  
Underlying hypertension:       0.428
Yes 12 3 0 3 1  
No 31 6 5 4 7  
Diabetes mellitus:       0.274
Yes 3 1 0 2 0  
No 40 8 5 5 8  
Sepsis:       0.096
Yes 16 5 5 4 4  
No 27 4 0 3 4  
Post HSCT:       0.347
Yes 8 0 0 0 1  
No 35 9 5 7 7  
Disease status:       0.409
Remission 6 2 0 0 0  
Active 37 7 5 7 8  
CNS involvement:       <0.001
Yes 0 0 0 5 1  
No 43 9 5 2 7  
Leukocyte count:       0.642
≥100,000 cells/μl 9 2 0 1 0  
<100,000 cells/μl 34 7 5 6 8  
Platelet count:       0.560
≥20,000 cells/μl 27 6 3 6 4  
<20,000 cells/μl 16 3 2 1 4  
Prothrombin time:       0.493
INR ≥1.5 10 2 1 1 1  
INR <1.5 32 7 4 6 7  
Location:       
Cerebral cortex 37 7 5 4 5 0.326
Basal ganglia 9 1 1 1 1 0.941
Brainstem 4 0 0 1 0 0.628
Cerebellum 4 2 0 1 3 0.213
Multiple 20 5 0 3 5 0.240
Type:       
Intraparenchymal hemorrhage 35 7 5 4 5 0.336
Subarachnoid hemorrhage 8 2 2 0 3 0.349
Subdural hemorrhage 11 2 1 4 4 0.307
Epidural hemorrhage 1 0 0 0 2 0.041
Intraventricular hemorrhage 10 4 1 3 2 0.618
  1. ALL = acute lymphoblastic leukemia; AML = acute myeloid leukemia; APL = acute promyelocytic leukemia; CNS = central nervous system; HSCT = hematopoietic stem cell transplantation; INR = international normalized ratio.