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Table 2 Characteristics of datasets used for external validation of prediction rules.

From: How well do clinical prediction rules perform in identifying serious infections in acutely ill children across an international network of ambulatory care datasets?

Dataset Setting Country N Age, years; mean (range) Prevalence ofserious infection % (95% CI) Inclusion criteria Exclusion criteria
Van den Bruel et al. 2007 [7] GP/AP/ED BE 4102 5.0 (0.0 to 16.9) 0.8 (0.5 to 1.1) Children ≤16 years with acute illness max 5 days Traumatic or neurological illness, intoxication, psychiatric or behavioral problems without somatic cause or an exacerbation of a chronic condition. No repeated inclusion of same infant within 5 days. Exclusion of physicians if the assumption of consecutive inclusion was probably violated
Roukema et al. 2008 [24] ED NL 1750 2.9 (0.1 to 15.7) 12.3 (10.8 to 13.9) All children with fever (>38°C) at ED, without meningeal irritation Chronic disease, Immunodeficiency
Bleeker et al. 2007 [25] ED NL 595 0.9 (0.0 to 3.0) 23.0 (19.6 to 26.4) Children with fever T>38°C at ED, no clear focus identified after evaluation GP of history by pediatrician Chronic disease, Immunodeficiency
Monteny et al. 2008 [22] GP NL 506 2.2 (0.3 to 5.9) 4.0 (2.3 to 5.7) Children aged 3 months to 6 years, contacting a GP cooperative after hours with fever as the presenting symptom Language barriers, no repeated inclusion within the previous two weeks
Brent et al. 2011 [23] ED UK 2777 3.3 (0.0 to 18.4) 5.3 (4.5 to 6.1) All children presenting with a medical problem to the pediatric emergency-care unit whatever their age Children who required immediate resuscitation. Comorbidity and chronic illness
Thompson et al. 2009 [18] PAU UK 700 4.6 (0.0 to 16.0) 37.7 (34.1 to 41.3) Children aged 3 months to 16 years with suspected acute infection Children with diseases liable to cause repeated serious bacterial infection, and infections resulting from penetrating trauma
Oostenbrink et al. 2004 [26] ED NL 593 3.7 (0.1 to 16.1) 43.8 (39.8 to 47.9) Children aged 1 month to 16 years, meningeal signs at GP, pediatrician-referred or self-referred with neck pain Comorbidity, ventriculoperitoneal drain
  1. AP, ambulatory pediatric care; BE, Belgium; CI, confidence interval; ED, emergency department; GP, general practice; NL, the Netherlands; PAU, pediatric assessment unit; UK, United Kingdom.