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Table 1 Multivariate Cox regression analysis of the eight-gene signature for predicting relapse-free survival in cancer patients

From: Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity

Variable Hazard ratio 95% CI P-value
Lung cancer (n = 71)    
Eight-gene signature 5.33 1.76 to 16.1 0.003
Age 1.05 1.00 to 1.11 0.060
Gender (Male vs Female) 1.33 0.48 to 3.68 0. 581
Stage (1 vs 2) 2.69 1.12 to 6.45 0.027
Histology Type 1.45 0.56 to 3.73 0.443
Breast cancer (n = 462)
Eight-gene signature 1.81 1.19 to 2.76 0.006
Age (>50 vs 50) 1.04 0.70 to 1.56 0.834
Clinical nodal status (positive vs negative) 2.47 1.45 to 4.18 0.0008
Clinical tumor stage (T3 or T4 vs T1 or T2) 1.80 1.20 to 2.70 0. 004
ER status (IHC positive vs negative) 0.44 0.29 to 0.67 0.0001
  1. * A total of 46 patients were excluded from the multivariate analysis due to incomplete data in the breast cancer cohort.