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Table 2 Overview on serum marker features at 90% sensitivity

From: Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors

  NF1 marker MPNST marker
  IFN-γ EGFR IL-6 TNF-α IGFBP1 RANTES
Sensitivity: 90,4 90,4 90,4 90,4 90,0 90,0
Specificity: 70,7 14,6 51,2 68,3 50,0 25,7
NPV 88,0 60,3 84,2 87,7 79,3 72,0
PPV 75,5 51,4 64,9 74,0 65,9 58,1
cut off (ng/ml): 0,15 8,57 0,34 0,59 13,77 30,72
  1. The prevalence for NF1 markers was set at 0.5, while the prevalence for MPNST markers was set at 10%. The risk of NF1 patients to develop an MPNST is 8-13%.