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Table 2 Overview on serum marker features at 90% sensitivity

From: Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors

 

NF1 marker

MPNST marker

 

IFN-γ

EGFR

IL-6

TNF-α

IGFBP1

RANTES

Sensitivity:

90,4

90,4

90,4

90,4

90,0

90,0

Specificity:

70,7

14,6

51,2

68,3

50,0

25,7

NPV

88,0

60,3

84,2

87,7

79,3

72,0

PPV

75,5

51,4

64,9

74,0

65,9

58,1

cut off (ng/ml):

0,15

8,57

0,34

0,59

13,77

30,72

  1. The prevalence for NF1 markers was set at 0.5, while the prevalence for MPNST markers was set at 10%. The risk of NF1 patients to develop an MPNST is 8-13%.
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BMC Medicine

ISSN: 1741-7015

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