Comparison of annual net healthcare costs for RV vaccination strategies. Net undiscounted annual healthcare costs for universal (A) and targeted RV vaccination (B) compared to no vaccination under different assumptions and corresponding 95% CI. ‘Basecase’ represents results when the vaccine price per course is €75 per child, coverage is 88%, and no herd immunity is present. ‘Vaccine price low’ and ‘high’ represent results for a vaccine price per course of €60 and €95 per vaccinated child, respectively. ‘Herd immunity’ includes protection of unvaccinated children. A scenario with herd immunity effects was not included for targeted vaccination. ‘Best case’ represents results from a low vaccine price, coverage of 97% and presence of herd immunity. ‘Worst case’ represents a high vaccine price, coverage of 65% and no herd immunity. ‘Vaccine Free Market Price’ shows results when the current listed vaccine price is used without any tender effects. CI:confidence interval; RV: rotavirus.