Comparison of cost-effectiveness of RV vaccination strategies. Cost per QALY gained (mean and 95% CI) for universal (A) and targeted RV vaccination (B), using a healthcare provider perspective and a discount rate of 3% for both costs and effects, under different assumptions. ‘Basecase’ represents results when the vaccine price per course is €75 per child, coverage is 88%, and no herd immunity is present. ‘Vaccine price low’ and ‘high’ represent results for vaccine price per course of €60 and €95 per vaccinated child, respectively, for universal RV vaccination and vaccine price per course of €80 and €120 for targeted RV vaccination. ‘Herd immunity’ includes protection of unvaccinated children (only used in universal RV vaccination). ‘QALY2’ represents results when QALY loss of caretakers is taken into account. ‘Best case’ represents results from a low vaccine price, coverage of 97%, including caretaker QALY’s and presence of herd immunity. ‘Worst case’ represents a high vaccine price, coverage of 65%, no caretaker QALY’s included and no herd immunity. ‘Vaccine Free Market Price’ shows results when the current listed vaccine price is used without any tender effects under base-case assumptions. CI: confidence interval; QALY: quality-adjested life year; RV: rotavirus.