Recurrent mutations in CLL. The size of each gene symbol is proportional to the logarithm of the mutational frequency of the corresponding gene as described in Quesada et al. (2011) and Wang et al. (2011) ([24, 25], respectively). Frequencies have been corrected for gene size and codon composition as reported in Quesada et al. Genes in red are mutated preferentially in IGHV-unmutated cases, genes in blue are mutated in IGHV-mutated cases and genes in purple are mutated in both.