Distribution of frequent mutations in CLL. Red boxes indicate which patients carry somatic mutations in any of the 50 most frequently mutated genes in CLL from two whole-exome studies: Quesada et al. (2011) (case ID in black) and Wang et al. (2011) (case ID in blue) ([24, 25], respectively). Red boxes also indicate whether the patient was treated before sample collection (Chemotherapy), whether deletion of 13q14 was detected (13q14_del), and whether the disease was classified as IGHV-unmutated (IGHV-Unmut).