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Table 2 Research domain criteria, October 2012 (constructs are listed within each domain)

From: Toward the future of psychiatric diagnosis: the seven pillars of RDoC

Negative valence domain Positive valence systems Cognitive systems Systems for social processes Arousal/modulatory systems
Acute threat (‘fear’) Approach motivation Attention Affiliation and attachment Arousal
Potential threat (‘anxiety’) Initial responsiveness to reward Perception Social communication Biological rhythms
Sustained threat Sustained responsiveness to reward Working memory Perception and understanding of self Sleep-wake
Loss Reward learning Declarative memory Perception and understanding of others  
Frustrative nonreward Habit Language behavior   
   Cognitive (effortful) control